Spontaneous Coronary Artery Dissection in a Young Man with a Factor V Leiden Gene Mutation: A Case Report and Review of the Literature

Tahir Khan; Peter Danyi; On Topaz; Asghar Ali; Ion S. Jovin

doi:10.1055/s-0033-1347932

International Journal of Angiology, Table of Contents

Int J Angiol 2013; 22(04): 251-254
DOI: 10.1055/s-0033-1347932

Case Report

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Spontaneous Coronary Artery Dissection in a Young Man with a Factor V Leiden Gene Mutation: A Case Report and Review of the Literature

Authors

Tahir Khan

¹Department of Medicine, Virginia Commonwealth University, Richmond, Virginia
Peter Danyi

¹Department of Medicine, Virginia Commonwealth University, Richmond, Virginia

²Department of Medicine, McGuire VA Medical Center, Richmond, Virginia
On Topaz

¹Department of Medicine, Virginia Commonwealth University, Richmond, Virginia

²Department of Medicine, McGuire VA Medical Center, Richmond, Virginia
Asghar Ali

¹Department of Medicine, Virginia Commonwealth University, Richmond, Virginia

²Department of Medicine, McGuire VA Medical Center, Richmond, Virginia
Ion S. Jovin

¹Department of Medicine, Virginia Commonwealth University, Richmond, Virginia

²Department of Medicine, McGuire VA Medical Center, Richmond, Virginia

Abstract

Spontaneous coronary artery dissection is a rare but increasingly recognized cause of acute myocardial ischemia in young adults, especially in women. We report a case of spontaneous coronary dissection in a young healthy man who was also a carrier of the factor V Leiden gene mutation.

Keywords

spontaneous coronary artery dissection - myocardial infarction - acute coronary syndrome - factor V Leiden gene mutation

Full Text

References

References
1 Vanzetto G, Berger-Coz E, Barone-Rochette G , et al. Prevalence, therapeutic management and medium-term prognosis of spontaneous coronary artery dissection: results from a database of 11,605 patients. Eur J Cardiothorac Surg 2009; 35 (2) 250-254
2 Celik SK, Sagcan A, Altintig A, Yuksel M, Akin M, Kultursay H. Primary spontaneous coronary artery dissections in atherosclerotic patients. Report of nine cases with review of the pertinent literature. Eur J Cardiothorac Surg 2001; 20 (3) 573-576
3 Thompson EA, Ferraris S, Gress T, Ferraris V. Gender differences and predictors of mortality in spontaneous coronary artery dissection: a review of reported cases. J Invasive Cardiol 2005; 17 (1) 59-61
4 Nalbandian RM, Chason JL. Intramural (intramedial) dissecting hematomas in normal or otherwise unremarkable coronary arteries. A “rare” cause of death. Am J Clin Pathol 1965; 43: 348-356
5 Shamloo BK, Chintala RS, Nasur A , et al. Spontaneous coronary artery dissection: aggressive vs. conservative therapy. J Invasive Cardiol 2010; 22 (5) 222-228
6 Basso C, Morgagni GL, Thiene G. Spontaneous coronary artery dissection: a neglected cause of acute myocardial ischaemia and sudden death. Heart 1996; 75 (5) 451-454
7 Mansourati J, Da Costa A, Munier S , et al. Prevalence of factor V Leiden in patients with myocardial infarction and normal coronary angiography. Thromb Haemost 2000; 83 (6) 822-825
8 Tanis BC, Bloemenkamp DG, van den Bosch MA , et al. Prothrombotic coagulation defects and cardiovascular risk factors in young women with acute myocardial infarction. Br J Haematol 2003; 122 (3) 471-478
9 Orlandi G, Pellegrinetti A, Fioretti C, Martini A, Murri L. Factor V Leiden mutation in a case with ischemic stroke: which relationship? A case report. Angiology 1998; 49 (1) 79-82
10 Cardon C, Diemont F, Julia P, Chemla E, Fabiani JN. Bilateral carotid dissection and factor V mutation: a second case. Ann Vasc Surg 2000; 14 (5) 503-506
11 Cheung S, Mithani V, Watson RM. Healing of spontaneous coronary dissection in the context of glycoprotein IIB/IIIA inhibitor therapy: a case report. Catheter Cardiovasc Interv 2000; 51 (1) 95-100
12 Zupan I, Noc M, Trinkaus D, Popovic M. Double vessel extension of spontaneous left main coronary artery dissection in young women treated with thrombolytics. Catheter Cardiovasc Interv 2001; 52 (2) 226-230
13 Koller PT, Cliffe CM, Ridley DJ. Immunosuppressive therapy for peripartum-type spontaneous coronary artery dissection: case report and review. Clin Cardiol 1998; 21 (1) 40-46