Obstructive jaundice can have various causes, and both neoplastic and non-neoplastic
lesions have to be considered. In cases of malignant disease, the tumors are usually
located in the extrahepatic bile ducts, the pancreatic head, or the ampulla of Vater
[1]. In rare cases, the causative lesion originates from the duodenum [2]
[3].
A 67-year-old man presented with nonspecific right upper quadrant pain and icterus.
Laboratory analysis revealed marked cholestasis: alkaline phosphatase 607 U/L (normal
35 – 129 U/L), gamma glutamyltransferase 1595 U/L (normal 0 – 66 U/L), and total bilirubin
27.2 mg/dL (normal 0 – 1 mg/dL). At endoscopy, a huge villous duodenal adenoma was
detected, which covered almost the entire duodenal wall ([Fig. 1]). Intubation of the ampulla of Vater was impossible. A computed tomography (CT)
scan showed an irregular, polypoid tumor that was protruding into the duodenal lumen,
but was confined to the bowel wall ([Fig. 2]).
Fig. 1 Endoscopic view showing a circumferential villous adenoma carpeting almost the entire
duodenal wall.
Fig. 2 Abdominal computed tomography (CT) scan showing an irregular polypoid tumor mass
protruding into the duodenal lumen (arrows).
The pancreaticoduodenectomy specimen subsequently showed an intraduodenal villous
tumor measuring 12.5 cm in its largest diameter. The cut surface of the ampulla was
firm, yellow–white, and suspicious of malignancy ([Fig. 3]). This area measured 1.5 cm in its largest diameter. Histology revealed a villous
adenoma (with low and high grade dysplasia) with progression to poorly differentiated
ampullary adenocarcinoma that was invading both the pancreas and the peripancreatic
soft tissue ([Fig. 4]). Seven regional lymph node metastases were identified. The patient’s postoperative
course was uneventful and he was discharged in good condition 10 days after surgery.
Fig. 3 Macroscopic appearance of the resection specimen showing: a a huge intraduodenal villous adenoma, measuring 12.5 cm in its largest diameter;
b the cut surface of the ampulla, which was yellow–white, firm, and suspicious of malignancy
(arrows).
Fig. 4 Microscopic appearance of the resection specimen showing: a a villous adenoma with low and high grade dysplasia (hematoxylin and eosin [H&E]
stain; original magnification × 100); b areas of progression to poorly differentiated adenocarcinoma (H&E stain; original
magnification × 100).
Villous adenomas of the duodenum have a predilection for the ampullary region, tend
to present with obstructive jaundice, especially if malignancy is present, and frequently
show cancerous change [2]. It has been reported by Pezet et al. [3] that jaundice, but not tumor size, is predictive of malignancy. Even when biopsies
are available, the diagnosis of cancer is frequently missed and it may be impossible
to assess the presence of invasive adenocarcinoma without complete excision of the
lesion [2].
Endoscopy_UCTN_Code_CCL_1AZ_2AI
