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Exp Clin Endocrinol Diabetes 2013; 121(06): 372-374
DOI: 10.1055/s-0033-1341520
Short Communication
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Prevalence of Cardiovascular Disease and Risk Factors in the Chinese Population with Impaired Glucose Regulation: the 2007–2008 China National Diabetes and Metabolic Disorders Study

Z. Yang   *
1   China-Japan Friendship Hospital, Beijing
,
X. Xing   *
1   China-Japan Friendship Hospital, Beijing
,
J. Xiao
1   China-Japan Friendship Hospital, Beijing
,
J. Lu
2   Chinese People’s Liberation Army General Hospital, Beijing
,
J. Weng
3   Sun Yat-sen University Third Hospital, Guangzhou
,
W. Jia
4   Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Shanghai
,
L. Ji
5   Peking University People’s Hospital, Beijing
,
Z. Shan
6   First Affiliated Hospital, Chinese Medical University, Liaoling
,
J. Liu
7   Shanxi Province People’s Hospital, Taiyuan, Shanxi
,
H. Tian
8   West China Hospital, Sichuan University, Chengdu, Sichuan
,
Q. Ji
9   Xijing Hospital, Fourth Military Medical University, Xi’an, Shanxi
,
D. Zhu
10   Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu
,
J. Ge
11   Xinjiang Uygur Autonomous Region’s Hospital, Urmqi, Xinjiang
,
L. Lin
12   Fujian Provincial Hospital, Fuzhou, Fujiang
,
L. Chen
13   Qilu Hospital, Qilu Hospital of Shandong University, Jinan, Shandong
,
X. Guo
14   Peking University First Hospital, Beijing
,
Z. Zhao
15   Henan Province People’s Hospital, Zhengzhou, Henan
,
Q. Li
16   Second Affiliated Hospital of Harbin Medical University, Harbin, ­Heilongjiang
,
Z. Zhou
17   Xiangya Second Hospital, Changsha, Hunan
,
G. Shan
18   Peking Union Medical College, Beijing
,
W. Yang
1   China-Japan Friendship Hospital, Beijing
,
and the China National Diabetes and Metabolic Disorders Study Group › Author Affiliations
Further Information

Publication History

received 10 December 2012
first decision 18 March 2013

accepted 20 March 2013

Publication Date:
24 April 2013 (online)

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Abstract

Aims:

Cardiovascular disease (CVD) is one of the most common chronic diseases in China. This aim of this study is to determine the prevalence of CVDs and risk factors in Chinese impaired glucose regulation subjects.

Methods:

We used a multistage, stratified sampling method to select subjects from the general Chinese population aged 20 years and older. Subjects underwent an oral glucose tolerance test to identify normal glucose tolerance (NGT) and impaired glucose regulation including isolated impaired fasting glucose (i-IFG), impaired glucose tolerance (i-IGT), and combined IFG/IGT and diabetic mellitus (DM). A logistic regression analysis was performed to examine the association between glucose abnormalities and CVD events.

Results:

We identified that 34 293 subjects had NGT, 1 469 i-IFG, 4 571 i-IGT, 957 IFG/IGT and 4 949 DM. The age-sex standardized prevalence rate of cardiovascular disease was 1.06% (95% CI 0.87–1.28), 1.79% (95% CI 1.37–2.33) and 3.83% (95% CI 2.79–5.24) in NGT, impaired glucose regulation and DM, respectively. Among impaired glucose subjects, prevalence of defined CVD risk factors (smoking, overweight, obesity, hypertension and dyslipidemia) was 29.52% (95% CI: 27.8–31.21), 36.25% (95% CI: 34.29–38.26), 10.05% (95% CI: 8.86–11.37), 36.43% (95% CI: 34.53–38.36) and 69.96% (95% CI: 67.87–71.98), respectively. Compared to 1 risk factor, the odds ratios (ORs) of CVDs with 2, 3 or 4 risk factors were 1.94 (95% CI: 0.74–5.09), 2.76 (95% CI: 1.06–7.21) and 5.84 (95% CI: 1.68–20.26), respectively. Additionally, compared to i-IFGs, ORs of CVDs with i-IGT and IFG/IGT were 2.88 (95%CI 1.36–6.01) and 2.12 (95% CI 0.83–5.44), respectively.

Conclusion:

The prevalence of cardiovascular risk factors was high in the Chinese impaired glucose regulation population. The postprandial hyperglycemia is more associated with CVD than isolated fasting hyperglycemia.

Key words

diabetes - cardiovascular risk ­management - metabolic features
*

* These authors contributed equally to this work.


 

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