Anticancer Activity of Novel Thiophenes Containing a Biological Active Diphenylsulfone, Diazepin, Piperidine, Oxazepine, Acryladehyde and Sulfonamide Moieties

M. S. AlSaid; M. G. El-Gazzar; M. M. Ghorab

doi:10.1055/s-0033-1337928

Drug Research, Inhaltsverzeichnis

Drug Res (Stuttg) 2013; 63(05): 263-269
DOI: 10.1055/s-0033-1337928

Original Article

Anticancer Activity of Novel Thiophenes Containing a Biological Active Diphenylsulfone, Diazepin, Piperidine, Oxazepine, Acryladehyde and Sulfonamide Moieties

M. S. AlSaid

¹Medicinal, Aromatic and Poisonous Plants Research Center (MAPPRC), College of Pharmacy, King Saud Univ. Riyadh, Saudi Arabia

,

M. G. El-Gazzar

²Department of Drug Radiation Research, National Center for Radiation Research and Technology, Nasr City, Cairo, Egypt

,

M. M. Ghorab

¹Medicinal, Aromatic and Poisonous Plants Research Center (MAPPRC), College of Pharmacy, King Saud Univ. Riyadh, Saudi Arabia

²Department of Drug Radiation Research, National Center for Radiation Research and Technology, Nasr City, Cairo, Egypt

› Institutsangaben

Abstract

A variety of thiophene derivatives bearing diphenylsulfone 3,4, diazepines 5b, 6b, phenylamino 7, piperidine 8, benzylpiperidine 9, oxazepines 10b, 11b, acrylaldehydes 12–14 and benzeonesulfanamide 15 were synthesized. some newly synthesized compounds were evaluated for their in vitro cytotoxic activity against human tumor breast cancer cell lines. The tested compounds showed moderate to good cytotoxic activity and indeed, some of them were more potent than doxorubicin as a reference drug.

Key words

thiophenes - sulfone - diazepine - piperidine - oxazepine - acryladehyde - sulfonamide - cytotoxic activity

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