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Planta Med 2012; 78(17): 1837-1843
DOI: 10.1055/s-0032-1327828
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Novel Dibenzo[b,e]oxepinones from the Freshwater-Derived Fungus Chaetomium sp. YMF 1.02105

Kai-Ze Shen
1   School of Life Science, Southwest University, Beibei, Chongqing, Peopleʼs Republic of China
2   Laboratory for Conservation and Utilization of Bio-Resources, and Key Laboratory for Microbial Resources of the Chinese Ministry of Education, Yunnan University, Kunming, Peopleʼs Republic of China
,
Suo Gao
3   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Peopleʼs Republic of China
,
Yan-Xiu Gao
1   School of Life Science, Southwest University, Beibei, Chongqing, Peopleʼs Republic of China
2   Laboratory for Conservation and Utilization of Bio-Resources, and Key Laboratory for Microbial Resources of the Chinese Ministry of Education, Yunnan University, Kunming, Peopleʼs Republic of China
,
An-Ran Wang
1   School of Life Science, Southwest University, Beibei, Chongqing, Peopleʼs Republic of China
,
Yao-Bo Xu
1   School of Life Science, Southwest University, Beibei, Chongqing, Peopleʼs Republic of China
,
Rong Sun
1   School of Life Science, Southwest University, Beibei, Chongqing, Peopleʼs Republic of China
2   Laboratory for Conservation and Utilization of Bio-Resources, and Key Laboratory for Microbial Resources of the Chinese Ministry of Education, Yunnan University, Kunming, Peopleʼs Republic of China
,
Pei-Gen Hu
1   School of Life Science, Southwest University, Beibei, Chongqing, Peopleʼs Republic of China
,
Guo-Fu Yang
1   School of Life Science, Southwest University, Beibei, Chongqing, Peopleʼs Republic of China
,
Ai-Ji Li
1   School of Life Science, Southwest University, Beibei, Chongqing, Peopleʼs Republic of China
,
Dan Zhong
1   School of Life Science, Southwest University, Beibei, Chongqing, Peopleʼs Republic of China
,
Hai-Yang Liu
3   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Peopleʼs Republic of China
,
Jin-Yan Dong
1   School of Life Science, Southwest University, Beibei, Chongqing, Peopleʼs Republic of China
2   Laboratory for Conservation and Utilization of Bio-Resources, and Key Laboratory for Microbial Resources of the Chinese Ministry of Education, Yunnan University, Kunming, Peopleʼs Republic of China
› Author Affiliations
Further Information

Publication History

received 06 December 2011
revised 08 September 2012

accepted 14 September 2012

Publication Date:
24 October 2012 (online)

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Abstract

Six new dibenzo[b,e]oxepinone metabolites, chaetones A–F (1–6), as well as three known compounds, 1-hydroxy-6-methyl-8-hydroxymethylxanthone (7), citreorosein (8), and emodin (9), were obtained from a freshwater-derived fungal strain Chaetomium sp. YMF 1.02105. Their structures were established on the basis of extensive spectroscopic data analysis and comparison with spectroscopic data reported. Compounds 1–6 are further additions to the small group of dibenzo[b,e]oxepinones represented by arugosins A–H. Compounds 1–7 were tested for their cytotoxic activities against A549, Raji, HepG2, MCF-7, and HL-60 cell lines. The results showed that compound 3 had significant cytotoxicity with IC50 values of 1.2, 1.8, 1.9, 2.3, and 1.6 µg/mL, respectively, against the five cancer cell lines. All compounds showed modest antimicrobial activity against Staphylococcus aureus (ATCC 6538) in standard disk assays.

Key words

dibenzo[b,e]oxepinone - Chaetomium sp. - Chaetomiaceae - chaetones - cytotoxicity - antimicrobial activity
 

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