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Semin Speech Lang 2012; 33(03): 188-202
DOI: 10.1055/s-0032-1320039
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Transcranial Brain Stimulation to Treat Aphasia: A Clinical Perspective

Julius Fridriksson
1   Department of Communication Sciences and Disorders, University of South Carolina, Columbia, South Carolina
,
H. Isabel Hubbard
1   Department of Communication Sciences and Disorders, University of South Carolina, Columbia, South Carolina
,
Sarah Grace Hudspeth
1   Department of Communication Sciences and Disorders, University of South Carolina, Columbia, South Carolina
› Author Affiliations
Further Information

Publication History

Publication Date:
31 July 2012 (online)

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Abstract

Transcranial brain stimulation was first introduced and described during mid-1900s. Since that time, the literature on brain stimulation has expanded with spurious advances in techniques and applications, from its use as a purely investigative tool used to better understand brain mechanisms to its use as a clinical treatment for neurologic diseases. This article offers a brief overview of the development, history, and mechanisms of transcranial brain stimulation, as well as an in-depth discussion of transcranial magnetic stimulation and transcranial direct current stimulation; two methods currently being investigated as treatments for aphasia. Our aim is to provide speech-language pathologists with an overview of the current state of literature on transcranial brain stimulation, as initial findings show it may be a promising new tool for aphasia rehabilitation.

Keywords

Brain stimulation - aphasia - treatment - transcranial magnetic stimulation - transcranial direct current stimulation
 

  • References

  • 1 Kelly H, Brady MC, Enderby P. Speech and language therapy for aphasia following stroke. Cochrane Database Syst Rev 2010; (5) 1-40
    PubMedGoogle Scholar
  • 2 Robey RR. A meta-analysis of clinical outcomes in the treatment of aphasia. J Speech Lang Hear Res 1998; 41 (1) 172-187
    CrossrefPubMedGoogle Scholar
  • 3 Bhogal SK, Teasell R, Speechley M. Intensity of aphasia therapy, impact on recovery. Stroke 2003; 34 (4) 987-993
    CrossrefPubMedGoogle Scholar
  • 4 Crinion JT, Leff AP. Recovery and treatment of aphasia after stroke: functional imaging studies. Curr Opin Neurol 2007; 20 (6) 667-673
    CrossrefPubMedGoogle Scholar
  • 5 Fridriksson J. Preservation and modulation of specific left hemisphere regions is vital for treated recovery from anomia in stroke. J Neurosci 2010; 30 (35) 11558-11564
    CrossrefPubMedGoogle Scholar
  • 6 Green DW, Grogan A, Crinion J, Ali N, Sutton C, Price CJ. Language control and parallel recovery of language in individuals with aphasia. Aphasiology 2010; 24 (2) 188-209
    CrossrefPubMedGoogle Scholar
  • 7 Fridriksson J, Richardson JD, Fillmore P, Cai B. Left hemisphere plasticity and aphasia recovery. Neuroimage 2012; 60 (2) 854-863
    CrossrefPubMedGoogle Scholar
  • 8 Turkeltaub PE, Coslett HB, Thomas AL , et al. The right hemisphere is not unitary in its role in aphasia recovery. Cortex 2011; ; In press
    PubMedGoogle Scholar
  • 9 Norton A, Zipse L, Marchina S, Schlaug G. Melodic intonation therapy: shared insights on how it is done and why it might help. Ann N Y Acad Sci 2009; 1169: 431-436
    CrossrefPubMedGoogle Scholar
  • 10 Baker JM, Rorden C, Fridriksson J. Using transcranial direct-current stimulation to treat stroke patients with aphasia. Stroke 2010; 41 (6) 1229-1236
    CrossrefPubMedGoogle Scholar
  • 11 Fridriksson J, Richardson JD, Baker JM, Rorden C. Transcranial direct current stimulation improves naming reaction time in fluent aphasia: a double-blind, sham-controlled study. Stroke 2011; 42 (3) 819-821
    CrossrefPubMedGoogle Scholar
  • 12 Fiori V, Coccia M, Marinelli CV , et al. Transcranial direct current stimulation improves word retrieval in healthy and nonfluent aphasic subjects. J Cogn Neurosci 2011; 23 (9) 2309-2323
    CrossrefPubMedGoogle Scholar
  • 13 Holland R, Leff AP, Josephs O , et al. Speech facilitation by left inferior frontal cortex stimulation. Curr Biol 2011; 21 (16) 1403-1407
    CrossrefPubMedGoogle Scholar
  • 14 Naeser MA, Martin PI, Nicholas M , et al. Improved picture naming in chronic aphasia after TMS to part of right Broca's area: an open-protocol study. Brain Lang 2005; 93 (1) 95-105
    CrossrefPubMedGoogle Scholar
  • 15 Naeser MA, Martin PI, Nicholas M , et al. Improved naming after TMS treatments in a chronic, global aphasia patient—case report. Neurocase 2005; 11 (3) 182-193
    CrossrefPubMedGoogle Scholar
  • 16 Naeser MA, Martin PI, Treglia E , et al. Research with rTMS in the treatment of aphasia. Restor Neurol Neurosci 2010; 28 (4) 511-529
    PubMedGoogle Scholar
  • 17 Naeser MA, Martin PI, Lundgren K , et al. Improved language in a chronic nonfluent aphasia patient after treatment with CPAP and TMS. Cogn Behav Neurol 2010; 23 (1) 29-38
    CrossrefPubMedGoogle Scholar
  • 18 Naeser MA, Martin PI, Ho M , et al. Transcranial magnetic stimulation and aphasia rehabilitation. Arch Phys Med Rehabil 2012; 93 (1, Suppl) S26-S34
    CrossrefPubMedGoogle Scholar
  • 19 Martin PI, Naeser MA, Ho M , et al. Overt naming fMRI pre- and post-TMS: two nonfluent aphasia patients, with and without improved naming post-TMS. Brain Lang 2009; 111 (1) 20-35
    CrossrefPubMedGoogle Scholar
  • 20 Hamilton RH, Sanders L, Benson J , et al. Stimulating conversation: enhancement of elicited propositional speech in a patient with chronic non-fluent aphasia following transcranial magnetic stimulation. Brain Lang 2010; 113 (1) 45-50
    CrossrefPubMedGoogle Scholar
  • 21 Barwood CH, Murdoch BE, Whelan BM , et al. Improved language performance subsequent to low-frequency rTMS in patients with chronic non-fluent aphasia post-stroke. Eur J Neurol 2011; 18 (7) 935-943
    CrossrefPubMedGoogle Scholar
  • 22 Weiduschat N, Thiel A, Rubi-Fessen I , et al. Effects of repetitive transcranial magnetic stimulation in aphasic stroke: a randomized controlled pilot study. Stroke 2011; 42 (2) 409-415
    CrossrefPubMedGoogle Scholar
  • 23 Kang EK, Kim YK, Sohn HM, Cohen LG, Paik NJ. Improved picture naming in aphasia patients treated with cathodal tDCS to inhibit the right Broca's homologue area. Restor Neurol Neurosci 2011; 29 (3) 141-152
    PubMedGoogle Scholar
  • 24 Kim SG, Ogawa S. Biophysical and physiological origins of blood oxygenation level-dependent fMRI signals. J Cereb Blood Flow Metab 2012; 32 (7) 1188-1206
    Google Scholar
  • 25 Penfield W, Roberts L. Speech and Brain Mechanisms. Princeton: Princeton University Press; 1959
    Google Scholar
  • 26 Gualtierotti T, Paterson AS. Electrical stimulation of the unexposed cerebral cortex. J Physiol 1954; 125 (2) 278-291
    CrossrefPubMedGoogle Scholar
  • 27 Merton PA, Morton HB. Stimulation of the cerebral cortex in the intact human subject. Nature 1980; 285 (5762) 227
    CrossrefPubMedGoogle Scholar
  • 28 Barker AT, Jalinous R, Freeston IL. Non-invasive magnetic stimulation of human motor cortex. Lancet 1985; 1 (8437) 1106-1107
    PubMedGoogle Scholar
  • 29 Barker AT, Freeston IL, Jalinous R, Jarratt JA. Magnetic stimulation of the human brain and peripheral nervous system: an introduction and the results of an initial clinical evaluation. Neurosurgery 1987; 20 (1) 100-109
    PubMedGoogle Scholar
  • 30 George MS, Wassermann EM, Post RM. Transcranial magnetic stimulation: a neuropsychiatric tool for the 21st century. J Neuropsychiatry Clin Neurosci 1996; 8 (4) 373-382
    PubMedGoogle Scholar
  • 31 Di Lazzaro V, Oliviero A, Profice P , et al. Comparison of descending volleys evoked by transcranial magnetic and electric stimulation in conscious humans. Electroencephalogr Clin Neurophysiol 1998; 109 (5) 397-401
    CrossrefPubMedGoogle Scholar
  • 32 George MS. Transcranial magnetic stimulation for the treatment of depression. Expert Rev Neurother 2010; 10 (11) 1761-1772
    CrossrefPubMedGoogle Scholar
  • 33 O'Reardon JP, Solvason HB, Janicak PG , et al. Efficacy and safety of transcranial magnetic stimulation in the acute treatment of major depression: a multisite randomized controlled trial. Biol Psychiatry 2007; 62 (11) 1208-1216
    CrossrefPubMedGoogle Scholar
  • 34 Padberg F, George MS. Repetitive transcranial magnetic stimulation of the prefrontal cortex in depression. Exp Neurol 2009; 219 (1) 2-13
    CrossrefPubMedGoogle Scholar
  • 35 Oliveri M. Brain stimulation procedures for treatment of contralesional spatial neglect. Restor Neurol Neurosci 2011; 29 (6) 421-425
    PubMedGoogle Scholar
  • 36 Zaghi S, Thiele B, Pimentel D, Pimentel T, Fregni F. Assessment and treatment of pain with non-invasive cortical stimulation. Restor Neurol Neurosci 2011; 29 (6) 439-451
    PubMedGoogle Scholar
  • 37 Bentwich J, Dobronevsky E, Aichenbaum S , et al. Beneficial effect of repetitive transcranial magnetic stimulation combined with cognitive training for the treatment of Alzheimer's disease: a proof of concept study. J Neural Transm 2011; 118 (3) 463-471
    CrossrefPubMedGoogle Scholar
  • 38 Groppa S, Oliviero A, Eisen A , et al. A practical guide to diagnostic transcranial magnetic stimulation: report of an IFCN committee. Clin Neurophysiol 2012; 123 (5) 858-882
    CrossrefPubMedGoogle Scholar
  • 39 Hoyer EH, Celnik PA. Understanding and enhancing motor recovery after stroke using transcranial magnetic stimulation. Restor Neurol Neurosci 2011; 29 (6) 395-409
    PubMedGoogle Scholar
  • 40 Mori F, Koch G, Foti C, Bernardi G, Centonze D. The use of repetitive transcranial magnetic stimulation (rTMS) for the treatment of spasticity. Prog Brain Res 2009; 175: 429-439
    PubMedGoogle Scholar
  • 41 Wassermann EM, Zimmermann T. Transcranial magnetic brain stimulation: therapeutic promises and scientific gaps. Pharmacol Ther 2012; 133 (1) 98-107
    CrossrefPubMedGoogle Scholar
  • 42 Hoogendam JM, Ramakers GM, Di Lazzaro V. Physiology of repetitive magnetic transcranial stimulation of the human brain. Brain Stimulat 2010; 3 (2) 95-118
    CrossrefPubMedGoogle Scholar
  • 43 Rothwell JC, Thompson PD, Day BL, Boyd S, Marsden CD. Stimulation of the human motor cortex through the scalp. Exp Physiol 1991; 76 (2) 159-200
    PubMedGoogle Scholar
  • 44 Epstein CM, Schwartzberg DG, Davey KR, Sudderth DB. Localizing the site of magnetic brain stimulation in humans. Neurology 1990; 40 (4) 666-670
    CrossrefPubMedGoogle Scholar
  • 45 Hallett M, Epstein CM, Berardelli A, Sackeim H, Maccabee P. Topics in transcranial magnetic stimulation. Suppl Clin Neurophysiol 2000; 53: 301-311
    PubMedGoogle Scholar
  • 46 Pascual-Leone A, Gates JR, Dhuna A. Induction of speech arrest and counting errors with rapid-rate transcranial magnetic stimulation. Neurology 1991; 41 (5) 697-702
    CrossrefPubMedGoogle Scholar
  • 47 Murakami T, Restle J, Ziemann U. Effective connectivity hierarchically links temporoparietal and frontal areas of the auditory dorsal stream with the motor cortex lip area during speech perception. Brain Lang 2011; [Epub ahead of print]
    PubMedGoogle Scholar
  • 48 Whitney C, Kirk M, O'Sullivan J, Lambon Ralph MA, Jefferies E. Executive semantic processing is underpinned by a large-scale neural network: revealing the contribution of left prefrontal, posterior temporal, and parietal cortex to controlled retrieval and selection using TMS. J Cogn Neurosci 2012; 24 (1) 133-147
    CrossrefPubMedGoogle Scholar
  • 49 Floel A, Poeppel D, Buffalo EA , et al. Prefrontal cortex asymmetry for memory encoding of words and abstract shapes. Cereb Cortex 2004; 14 (4) 404-409
    CrossrefPubMedGoogle Scholar
  • 50 Pascual-Leone A, Valls-Solé J, Wassermann EM, Hallett M. Responses to rapid-rate transcranial magnetic stimulation of the human motor cortex. Brain 1994; 117 (Pt 4) 847-858
    CrossrefPubMedGoogle Scholar
  • 51 Pascual-Leone A, Hallett M. Induction of errors in a delayed response task by repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex. Neuroreport 1994; 5 (18) 2517-2520
    CrossrefPubMedGoogle Scholar
  • 52 Pascual-Leone A, Tormos JM, Keenan J, Tarazona F, Cañete C, Catalá MD. Study and modulation of human cortical excitability with transcranial magnetic stimulation. J Clin Neurophysiol 1998; 15 (4) 333-343
    PubMedGoogle Scholar
  • 53 Chen R, Classen J, Gerloff C , et al. Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation. Neurology 1997; 48 (5) 1398-1403
    CrossrefPubMedGoogle Scholar
  • 54 Kimbrell TA, Little JT, Dunn RT , et al. Frequency dependence of antidepressant response to left prefrontal repetitive transcranial magnetic stimulation (rTMS) as a function of baseline cerebral glucose metabolism. Biol Psychiatry 1999; 46 (12) 1603-1613
    CrossrefPubMedGoogle Scholar
  • 55 Feinsod M, Kreinin B, Chistyakov A, Klein E. Preliminary evidence for a beneficial effect of low-frequency, repetitive transcranial magnetic stimulation in patients with major depression and schizophrenia. Depress Anxiety 1998; 7 (2) 65-68
    CrossrefPubMedGoogle Scholar
  • 56 Tergau F, Wanschura V, Canelo M , et al. Complete suppression of voluntary motor drive during the silent period after transcranial magnetic stimulation. Exp Brain Res 1999; 124 (4) 447-454
    CrossrefPubMedGoogle Scholar
  • 57 Tsuji T, Rothwell JC. Long lasting effects of rTMS and associated peripheral sensory input on MEPs, SEPs and transcortical reflex excitability in humans. J Physiol 2002; 540 (Pt 1) 367-376
    CrossrefPubMedGoogle Scholar
  • 58 George MS, Wassermann EM, Williams WA , et al. Daily repetitive transcranial magnetic stimulation (rTMS) improves mood in depression. Neuroreport 1995; 6 (14) 1853-1856
    CrossrefPubMedGoogle Scholar
  • 59 Kakuda W, Abo M, Momosaki R, Morooka A. Therapeutic application of 6-Hz-primed low-frequency rTMS combined with intensive speech therapy for post-stroke aphasia. Brain Inj 2011; 25 (12) 1242-1248
    CrossrefPubMedGoogle Scholar
  • 60 Crosson B, Moore AB, McGregor KM , et al. Regional changes in word-production laterality after a naming treatment designed to produce a rightward shift in frontal activity. Brain Lang 2009; 111 (2) 73-85
    CrossrefPubMedGoogle Scholar
  • 61 Hamilton RH, Chrysikou EG, Coslett B. Mechanisms of aphasia recovery after stroke and the role of noninvasive brain stimulation. Brain Lang 2011; 118 (1-2) 40-50
    CrossrefPubMedGoogle Scholar
  • 62 Naeser MA, Martin PI, Theoret H , et al. TMS suppression of right pars triangularis, but not pars opercularis, improves naming in aphasia. Brain Lang 2011; 119 (3) 206-213
    CrossrefPubMedGoogle Scholar
  • 63 Winhuisen L, Thiel A, Schumacher B , et al. Role of the contralateral inferior frontal gyrus in recovery of language function in poststroke aphasia: a combined repetitive transcranial magnetic stimulation and positron emission tomography study. Stroke 2005; 36 (8) 1759-1763
    CrossrefPubMedGoogle Scholar
  • 64 Winhuisen L, Thiel A, Schumacher B , et al. The right inferior frontal gyrus and poststroke aphasia: a follow-up investigation. Stroke 2007; 38 (4) 1286-1292
    CrossrefPubMedGoogle Scholar
  • 65 Kakuda W, Abo M, Kaito N, Watanabe M, Senoo A. Functional MRI-based therapeutic rTMS strategy for aphasic stroke patients: a case series pilot study. Int J Neurosci 2010; 120 (1) 60-66
    CrossrefPubMedGoogle Scholar
  • 66 Kaplan E, Goodglass H, Weintraub S. Boston Naming Test. 2nd ed. Philadelphia: Lippincott, Williams, & Wilkins; 2001
    Google Scholar
  • 67 Goodglass H, Kaplan E, Barresi B. Boston Diagnostic Aphasia Examination. 3rd ed. San Antonio: PsychCorp; 2000
    Google Scholar
  • 68 Kertesz A. The Western Aphasia Battery—Revised. New York: Grune & Stratton; 2007
    Google Scholar
  • 69 Helms-Estabrooks N. Cognitive Linguistic Quick Test. San Antonio: PsychCorp; 2001
    Google Scholar
  • 70 Barwood CH, Murdoch BE, Whelan BM , et al. Improved expressive and receptive language abilities in nonfluent aphasic stroke patients after application of rTMS: an open protocol case series. Brain Stimul 2011; [Epub ahead of print]
    PubMedGoogle Scholar
  • 71 Kakuda W, Abo M, Uruma G, Kaito N, Watanabe M. Low-frequency rTMS with language therapy over a 3-month period for sensory-dominant aphasia: case series of two post-stroke Japanese patients. Brain Inj 2010; 24 (9) 1113-1117
    CrossrefPubMedGoogle Scholar
  • 72 Song S, Sandrini M, Cohen LG. Modifying somatosensory processing with non-invasive brain stimulation. Restor Neurol Neurosci 2011; 29 (6) 427-437
    PubMedGoogle Scholar
  • 73 Pascual-Leone A, Houser CM, Reese K , et al. Safety of rapid-rate transcranial magnetic stimulation in normal volunteers. Electroencephalogr Clin Neurophysiol 1993; 89 (2) 120-130
    PubMedGoogle Scholar
  • 74 Rossi S, Hallett M, Rossini PM, Pascual-Leone A ; Safety of TMS Consensus Group. Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research. Clin Neurophysiol 2009; 120 (12) 2008-2039
    CrossrefPubMedGoogle Scholar
  • 75 Nitsche MA, Paulus W. Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. J Physiol 2000; 527 (Pt 3) 633-639
    CrossrefPubMedGoogle Scholar
  • 76 Rosenkranz K, Nitsche MA, Tergau F, Paulus W. Diminution of training-induced transient motor cortex plasticity by weak transcranial direct current stimulation in the human. Neurosci Lett 2000; 296 (1) 61-63
    CrossrefPubMedGoogle Scholar
  • 77 Levy WJ, York DH, McCaffrey M, Tanzer F. Motor evoked potentials from transcranial stimulation of the motor cortex in humans. Neurosurgery 1984; 15 (3) 287-302
    CrossrefPubMedGoogle Scholar
  • 78 Mills KR, Murray NM, Hess CW. Magnetic and electrical transcranial brain stimulation: physiological mechanisms and clinical applications. Neurosurgery 1987; 20 (1) 164-168
    PubMedGoogle Scholar
  • 79 Fritsch B, Reis J, Martinowich K , et al. Direct current stimulation promotes BDNF-dependent synaptic plasticity: potential implications for motor learning. Neuron 2010; 66 (2) 198-204
    CrossrefPubMedGoogle Scholar
  • 80 Nitsche MA, Lampe C, Antal A , et al. Dopaminergic modulation of long-lasting direct current-induced cortical excitability changes in the human motor cortex. Eur J Neurosci 2006; 23 (6) 1651-1657
    CrossrefPubMedGoogle Scholar
  • 81 Bliss TV, Collingridge GL. A synaptic model of memory: long-term potentiation in the hippocampus. Nature 1993; 361 (6407) 31-39
    CrossrefPubMedGoogle Scholar
  • 82 Marangolo P, Marinelli CV, Bonifazi S , et al. Electrical stimulation over the left inferior frontal gyrus (IFG) determines long-term effects in the recovery of speech apraxia in three chronic aphasics. Behav Brain Res 2011; 225 (2) 498-504
    CrossrefPubMedGoogle Scholar
  • 83 Vines BW, Norton AC, Schlaug G. Non-invasive brain stimulation enhances the effects of melodic intonation therapy. Front Psychol 2011; 2: 230
    PubMedGoogle Scholar
  • 84 Monti A, Cogiamanian F, Marceglia S , et al. Improved naming after transcranial direct current stimulation in aphasia. J Neurol Neurosurg Psychiatry 2008; 79 (4) 451-453
    CrossrefPubMedGoogle Scholar
  • 85 You DS, Kim DY, Chun MH, Jung SE, Park SJ. Cathodal transcranial direct current stimulation of the right Wernicke's area improves comprehension in subacute stroke patients. Brain Lang 2011; 119 (1) 1-5
    CrossrefPubMedGoogle Scholar
  • 86 Datta A, Baker JM, Bikson M, Fridriksson J. Individualized model predicts brain current flow during transcranial direct-current stimulation treatment in responsive stroke patient. Brain Stimulat 2011; 4 (3) 169-174
    CrossrefPubMedGoogle Scholar
  • 87 Iyer MB, Mattu U, Grafman J, Lomarev M, Sato S, Wassermann EM. Safety and cognitive effect of frontal DC brain polarization in healthy individuals. Neurology 2005; 64 (5) 872-875
    CrossrefPubMedGoogle Scholar
  • 88 Nitsche MA, Liebetanz D, Lang N, Antal A, Tergau F, Paulus W. Safety criteria for transcranial direct current stimulation (tDCS) in humans. Clin Neurophysiol 2003; 114 (11) 2220-2222 , author reply 2222–2223
    CrossrefPubMedGoogle Scholar
  • 89 Bikson M, Datta A, Elwassif M. Establishing safety limits for transcranial direct current stimulation. Clin Neurophysiol 2009; 120 (6) 1033-1034
    CrossrefPubMedGoogle Scholar
  • 90 Kessler SK, Turkeltaub PE, Benson JG, Hamilton RH. Differences in the experience of active and sham transcranial direct current stimulation. Brain Stimul 2011; 5 (2) 155-162
    PubMedGoogle Scholar
  • 91 Fregni F, Boggio PS, Nitsche M , et al. Anodal transcranial direct current stimulation of prefrontal cortex enhances working memory. Exp Brain Res 2005; 166 (1) 23-30
    CrossrefPubMedGoogle Scholar
  • 92 DaSilva AF, Volz MS, Bikson M, Fregni F. Electrode positioning and montage in transcranial direct current stimulation. J Vis Exp 2011; (51) pii:2744
    PubMedGoogle Scholar
  • 93 Bikson M, Datta A, Rahman A, Scaturro J. Electrode montages for tDCS and weak transcranial electrical stimulation: role of “return” electrode's position and size. Clin Neurophysiol 2010; 121 (12) 1976-1978
    CrossrefPubMedGoogle Scholar
  • 94 Datta A, Bansal V, Diaz J, Patel J, Reato D, Bikson M. Gyri -precise head model of transcranial DC stimulation: improved spatial focality using a ring electrode versus conventional rectangular pad. Brain Stimulat 2009; 2 (4) 201-207
    CrossrefPubMedGoogle Scholar
  • 95 Dmochowski JP, Datta A, Bikson M, Su Y, Parra LC. Optimized multi-electrode stimulation increases focality and intensity at target. J Neural Eng 2011; 8 (4) 046011
    CrossrefPubMedGoogle Scholar
  • 96 Martin PI, Naeser MA, Theoret H , et al. Transcranial magnetic stimulation as a complementary treatment for aphasia. Semin Speech Lang 2004; 25 (2) 181-191
    Article in Thieme ConnectPubMedGoogle Scholar