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Semin Thromb Hemost 2012; 38(05): 433-446
DOI: 10.1055/s-0032-1315757
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Acquired Inhibitors of Coagulation Factors: Part I—Acquired Hemophilia A

Antonio Coppola
1   Department of Clinical and Experimental Medicine, Regional Reference Center for Coagulation Disorders, Federico II University Hospital, Naples, Italy
,
Emmanuel J. Favaloro
2   Department of Haematology, Institute of Clinical Pathology and Medical Research (ICPMR), Westmead Hospital, Westmead, Australia
,
Antonella Tufano
1   Department of Clinical and Experimental Medicine, Regional Reference Center for Coagulation Disorders, Federico II University Hospital, Naples, Italy
,
Matteo N.D. Di Minno
1   Department of Clinical and Experimental Medicine, Regional Reference Center for Coagulation Disorders, Federico II University Hospital, Naples, Italy
,
Anna Maria Cerbone
1   Department of Clinical and Experimental Medicine, Regional Reference Center for Coagulation Disorders, Federico II University Hospital, Naples, Italy
,
Massimo Franchini
3   Department of Transfusion Medicine and Hematology, C. Poma Hospital, Mantova, Italy
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Publikationsverlauf

Publikationsdatum:
27. Juni 2012 (online)

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Abstract

Acquired hemophilia A (AHA) is a rare, but often severe, bleeding disorder caused by autoantibodies against clotting factor VIII (FVIII). AHA occurs more frequently in the elderly and in association with several conditions, such as malignancies, autoimmune diseases, postpartum, or drug exposure; however, about half of the cases remain idiopathic. At variance with congenital hemophilia, where hemarthroses are the most common bleeding symptoms, hemorrhages in AHA involving soft tissues (muscle, skin) are more frequently reported. AHA is diagnosed in patients: with negative personal or family bleeding history; in which prolonged activated partial thromboplastin time is not corrected after mixing and incubating equal volumes of patient and normal plasma for ~2 hours at 37°C; FVIII levels are reduced; and a specific FVIII-inhibiting activity is detected. Prompt recognition and treatment of AHA are mandatory, as inadequate management and complications of the disease are associated with high mortality rates. Therapeutic approaches should aim to control acute bleeds, eradicate FVIII-autoantibody production, treat associated diseases, and when possible, eliminate them. Present knowledge about this often overlooked and challenging condition has significantly increased following establishment of recent national and international studies, as will also be reviewed in this article.

Keywords

acquired hemophilia A - autoantibodies - bleeding - inhibitors
 

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