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Neuropediatrics 2012; 43(03): 155-158
DOI: 10.1055/s-0032-1315430
Short Communication
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Medulloblastoma in a Child with Fragile X Syndrome

Authors

  • George A. Alexiou

    1   Department of Neurosurgery, Children's Hospital “Agia Sofia,” Athens, Greece

  • George Siozos

    2   Department of Pathology, Children's Hospital “Agia Sofia,” Athens, Greece

  • Kalliopi Stefanaki

    2   Department of Pathology, Children's Hospital “Agia Sofia,” Athens, Greece

  • Eustathios Vlachakis

    1   Department of Neurosurgery, Children's Hospital “Agia Sofia,” Athens, Greece

  • George Sfakianos

    1   Department of Neurosurgery, Children's Hospital “Agia Sofia,” Athens, Greece

  • Neofytos Prodromou

    1   Department of Neurosurgery, Children's Hospital “Agia Sofia,” Athens, Greece

  • Maria Moschovi

    3   Department of Hematology Oncology, Unit of 1st Department of Pediatrics of Athens University, Children's Hospital “Agia Sofia,” Athens, Greece
Further Information

Publication History

13 June 2011

30 April 2012

Publication Date:
17 May 2012 (online)

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Abstract

Fragile X syndrome is the most common cause of inherited intellectual impairment and has been associated with decreased incidence of cancer. We present the case of an 11-year-old boy with a diagnosis of fragile X syndrome who presented with gait imbalance, headache, and episodes of vomiting. Radiological investigation revealed the presence of a posterior fossa tumor. The patient was operated upon and the tumor proved to be a medulloblastoma (MB). To the best of our knowledge this is the first reported case of MB in a child with fragile X syndrome.

Keywords

medulloblastoma - fragile X syndrome - children