Gentiocrucines A–E, Five Unusual Lactonic Enamino Ketones from Swertia macrosperma and Swertia angustifolia

Hong-Ling Wang; Kang He; Chang-An Geng; Xue-Mei Zhang; Yun-Bao Ma; Jie Luo; Ji-Jun Chen

doi:10.1055/s-0032-1315392

Planta Medica, Table of Contents

Planta Med 2012; 78(17): 1867-1872
DOI: 10.1055/s-0032-1315392

Natural Product Chemistry

Original Papers

Georg Thieme Verlag KG Stuttgart · New York

Gentiocrucines A–E, Five Unusual Lactonic Enamino Ketones from Swertia macrosperma and Swertia angustifolia

Hong-Ling Wang^*

¹State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, PR China

²Graduate School of Chinese Academy of Sciences, Beijing, PR China

,

Kang He^*

¹State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, PR China

²Graduate School of Chinese Academy of Sciences, Beijing, PR China

,

Chang-An Geng

¹State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, PR China

,

Xue-Mei Zhang

¹State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, PR China

,

Yun-Bao Ma

¹State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, PR China

,

Jie Luo

¹State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, PR China

,

Ji-Jun Chen

¹State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, PR China

› Author Affiliations

Abstract

Five unusual lactonic enamino ketones, gentiocrucines A–E (1–5), were isolated from Swertia macrosperma and S. angustifolia. Their structures were determined based on extensive spectroscopic analyses (IR, UV, MS, 1D- and 2D-NMR). By anti-HBV assay on the HepG 2.2.15 cell line in vitro, compound 1 inhibited both the secretion of hepatitis B virus surface antigen (HBsAg) and hepatitis B virus e antigen (HBeAg) with IC₅₀ values of 3.14 and 3.35 mM, and compound 5 only inhibited the secretion of HBsAg with an IC₅₀ value of 2.07 mM.

Key words

gentiocrucines A–E - Swertia macrosperma - Swertia angustifolia - Gentianaceae - lactonic enamino ketones - anti-HBV activity

Full Text

References

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