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Planta Med 2012; 78(17): 1867-1872
DOI: 10.1055/s-0032-1315392
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Gentiocrucines A–E, Five Unusual Lactonic Enamino Ketones from Swertia macrosperma and Swertia angustifolia

Hong-Ling Wang   *
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, PR China
2   Graduate School of Chinese Academy of Sciences, Beijing, PR China
,
Kang He   *
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, PR China
2   Graduate School of Chinese Academy of Sciences, Beijing, PR China
,
Chang-An Geng
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, PR China
,
Xue-Mei Zhang
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, PR China
,
Yun-Bao Ma
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, PR China
,
Jie Luo
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, PR China
,
Ji-Jun Chen
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, PR China
› Author Affiliations
Further Information

Publication History

received 19 June 2012
revised 10 August 2012

accepted 27 August 2012

Publication Date:
11 October 2012 (online)

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Abstract

Five unusual lactonic enamino ketones, gentiocrucines A–E (1–5), were isolated from Swertia macrosperma and S. angustifolia. Their structures were determined based on extensive spectroscopic analyses (IR, UV, MS, 1D- and 2D-NMR). By anti-HBV assay on the HepG 2.2.15 cell line in vitro, compound 1 inhibited both the secretion of hepatitis B virus surface antigen (HBsAg) and hepatitis B virus e antigen (HBeAg) with IC50 values of 3.14 and 3.35 mM, and compound 5 only inhibited the secretion of HBsAg with an IC50 value of 2.07 mM.

Key words

gentiocrucines A–E - Swertia macrosperma - Swertia angustifolia - Gentianaceae - lactonic enamino ketones - anti-HBV activity

* These authors contributed equally to this work and are co-first authors.


Supporting Information

 

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