Antiplasmodial and Antibacterial Activity of Compounds Isolated from Ormocarpum trichocarpum

Abstract

Using activity-guided fractionation based on in vitro antibacterial assays, five biflavonoids, among them two new ones, were isolated from the aerial parts of Ormocarpum trichocarpum. The isolated compounds showed MIC values in the range of 4.0 to 136.7 µM against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Klebsiella pneumonia and IC₅₀ values in the range of 4.30 to 94.32 µM against the chloroquine-sensitive D10 Plasmodium falciparum strain.

Key words

Ormocarpum trichocarpum - Papilionaceae - antiplasmodial activity - antibacterial activity - biflavanone - biscoumarin

• References

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