New Steroidal Saponins and Sterol Glycosides from Paris polyphylla var. yunnanensis

Xia Wu; Lei Wang; Guo-Cai Wang; Hui Wang; Yi Dai; Wen-Cai Ye; Yao-Lan Li

doi:10.1055/s-0032-1315239

Planta Medica, Table of Contents

Planta Med 2012; 78(15): 1667-1675
DOI: 10.1055/s-0032-1315239

Natural Product Chemistry

Original Papers

Georg Thieme Verlag KG Stuttgart · New York

New Steroidal Saponins and Sterol Glycosides from Paris polyphylla var. yunnanensis

Xia Wu

¹Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, PR China

²Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, PR China

,

Lei Wang

¹Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, PR China

²Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, PR China

,

Guo-Cai Wang

¹Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, PR China

²Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, PR China

,

Hui Wang

³School of Medicine, Jinan University, Guangzhou, PR China

,

Yi Dai

¹Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, PR China

²Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, PR China

,

Wen-Cai Ye

¹Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, PR China

²Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, PR China

,

Yao-Lan Li

¹Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, PR China

²Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, PR China

› Author Affiliations

Abstract

Four new steroidal saponins, pariposides A–D (1–4), and two new sterol glycosides, pariposides E–F (5-6), along with eight known steroidal saponins (7-14), two known sterol glycosides (15–16), and two known ecdysteroids (17–18), were isolated from the roots of Paris polyphylla var. yunnanensis. Among them, compounds 1–4 are the first spirostanol saponins with a peroxy group located between C-5 and C-8 of the aglycone. Their structures were determined by detailed spectroscopic analyses and chemical methods. All the isolated compounds were evaluated for their in vitro cytotoxicities against human nasopharyngeal carcinoma epithelial (CNE) cells, and steroidal saponins 7, 11, 13, and 14 showed a potent antiproliferative effect on CNE cells with IC₅₀ values of 9.2, 4.7, 11.1, and 2.7 µM, respectively.

Key words

Paris polyphylla var. yunnanensis - Liliaceae - steroidal saponin - sterol glycoside - cytotoxic activities

Full Text

References

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