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Planta Med 2012; 78(14): 1579-1593
DOI: 10.1055/s-0032-1315215
DOI: 10.1055/s-0032-1315215
Natural Product Chemistry
Original Papers
Structure Elucidation and Inhibitory Effects on NO Production of Clerodane Diterpenes from Ajuga decumbens
Further Information
Publication History
received 10 May 2012
revised 25 June 2012
accepted 12 July 2012
Publication Date:
07 August 2012 (online)
Abstract
Three new clerodane diterpenes (1–3), together with five known analogues (4–8), have been isolated from the whole plants of Ajuga decumbens. Their structures were established by detailed spectroscopic and spectrometric data analyses (IR, ESIMS, HR-ESIMS, 1D and 2D NMR). The inhibitory activities of these diterpenes on LPS-induced NO production were evaluated, and compounds 1–4 and 6–8 showed inhibitory effects.
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