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Planta Med 2012; 78(15): 1676-1682
DOI: 10.1055/s-0032-1315210
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Phragmalin-type Limonoids from Heynea trijuga

Wei Yang
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, PR China
2   Graduate School of Chinese Academy of Sciences, Beijing, PR China
,
Lingmei Kong
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, PR China
2   Graduate School of Chinese Academy of Sciences, Beijing, PR China
,
Yu Zhang
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, PR China
,
Guihua Tang
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, PR China
,
Feng Zhu
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, PR China
,
Shifei Li
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, PR China
,
Lingli Guo
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, PR China
,
Yuanyuan Cheng
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, PR China
,
Xiaojiang Hao
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, PR China
,
Hongping He
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, PR China
› Author Affiliations
Further Information

Publication History

received 09 May 2012
revised 06 July 2012

accepted 16 July 2012

Publication Date:
13 August 2012 (online)

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Abstract

Nine new phragmalin-type limonoids, heytrijumalins A–I (1–9), together with the known 15-acetyltrichagmalin E (10) were isolated from the branches and leaves of Heynea trijuga. The structures of these new compounds were elucidated on the basis of extensive spectroscopic analysis. Compounds 6 and 10 showed insecticidal activity at 100 ppm, with corrected mortalities of 82.94 % and 96.02 %, respectively. Compounds 2 and 10 showed weak cytotoxicity against HL-60 and A-549 human tumor cell lines, with IC50 values ranging from 14.55 to 25.27 µM.

Key words

Heynea trijuga - Meliaceae - phragmalin-type - limonoids - heytrijumalins A−I

Supporting Information

 

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