Protein Tyrosine Phosphatase 1B (PTP1B)-Inhibiting Constituents from the Leaves of Syzygium polyanthum

Azis Saifudin; Ken Tanaka; Shigetoshi Kadota; Yasuhiro Tezuka

doi:10.1055/s-0032-1315000

Planta Medica, Inhaltsverzeichnis

Planta Med 2012; 78(12): 1378-1381
DOI: 10.1055/s-0032-1315000

Natural Product Chemistry

Letters

Georg Thieme Verlag KG Stuttgart · New York

Protein Tyrosine Phosphatase 1B (PTP1B)-Inhibiting Constituents from the Leaves of Syzygium polyanthum

Azis Saifudin

¹Division of Natural Products Chemistry, Institute of Natural Medicine, University of Toyama, Toyama, Japan

,

Ken Tanaka

²Division of Pharmacognosy, Institute of Natural Medicine, University of Toyama, Toyama, Japan

,

Shigetoshi Kadota

¹Division of Natural Products Chemistry, Institute of Natural Medicine, University of Toyama, Toyama, Japan

,

Yasuhiro Tezuka

¹Division of Natural Products Chemistry, Institute of Natural Medicine, University of Toyama, Toyama, Japan

› Institutsangaben

Abstract

A methanol extract of the leaves of Syzygium polyanthum (Wight) Walp. afforded four new acylbenzene derivatives (1–4) together with seven known compounds (5–11). The structures of 1–11 were elucidated by extensive spectroscopic methods and comparison with the literature data. The new compounds 1–3 and a known compound, campest-4-en-3-one (10), exhibited a significant protein tyrosine phosphatase 1B inhibitory activity with IC₅₀ values of 13.1 ± 0.1, 5.77 ± 0.15, 4.01 ± 0.26, and 10.4 ± 0.5 µM, respectively. The inhibitory potency of the new compounds 2 and 3 was comparable to that of a positive control RK-682 (IC₅₀, 5.51 ± 0.04 µM).

Key words

protein tyrosin phosphatase 1B - PTP1B - Indonesian medicinal plant - Syzygium polyanthum - Myrtaceae - daun salam - salam

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Referenzen

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