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Semin Reprod Med 2012; 30(03): 243-252
DOI: 10.1055/s-0032-1311527
DOI: 10.1055/s-0032-1311527
Unique Patient Issues: Early Interventions and Management
Further Information
Publication History
Publication Date:
14 May 2012 (online)
Abstract
Patient cases that present with recurring fertilization failure or complete abnormality in either the oocytes or sperm before fertilization are uncommon, yet they are devastating. This review presents several such instances, including oocyte maturation blocks, empty follicle syndrome, oocyte activation failures, defects in sperm phospholipase C isoform ζ, sperm structural anomalies, spontaneous oocyte activation, and unexplained cases. Diagnostic efforts have not only provided insight into possible etiologies but also have helped manage such challenging cases. Interventions may comprise cellular, molecular, or genetic analyses of gametes, as well as functional assays and/or modified treatment strategies. Consequently, infertility professionals can increasingly rely on evidence-based counseling with respect to prognosis and treatment options.
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References
- 1 Beall S, Brenner C, Segars J. Oocyte maturation failure: a syndrome of bad eggs. Fertil Steril 2010; 94 (7) 2507-2513
- 2 Combelles CM, Albertini DF, Racowsky C. Distinct microtubule and chromatin characteristics of human oocytes after failed in-vivo and in-vitro meiotic maturation. Hum Reprod 2003; 18 (10) 2124-2130
- 3 Levran D, Farhi J, Nahum H, Glezerman M, Weissman A. Maturation arrest of human oocytes as a cause of infertility: case report. Hum Reprod 2002; 17 (6) 1604-1609
- 4 Chen ZQ, Ming TX, Nielsen HI. Maturation arrest of human oocytes at germinal vesicle stage. J Hum Reprod Sci 2010; 3 (3) 153-157
- 5 Hourvitz A, Maman E, Brengauz M, Machtinger R, Dor J. In vitro maturation for patients with repeated in vitro fertilization failure due to “oocyte maturation abnormalities.”. Fertil Steril 2010; 94 (2) 496-501
- 6 Schmiady H, Neitzel H. Arrest of human oocytes during meiosis I in two sisters of consanguineous parents: first evidence for an autosomal recessive trait in human infertility: case report. Hum Reprod 2002; 17 (10) 2556-2559
- 7 Eichenlaub-Ritter U, Schmiady H, Kentenich H, Soewarto D. Recurrent failure in polar body formation and premature chromosome condensation in oocytes from a human patient: indicators of asynchrony in nuclear and cytoplasmic maturation. Hum Reprod 1995; 10 (9) 2343-2349
- 8 Hartshorne G, Montgomery S, Klentzeris L. A case of failed oocyte maturation in vivo and in vitro. Fertil Steril 1999; 71 (3) 567-570
- 9 Harrison KL, Sherrin DA, Keeping JD. Repeated oocyte maturation block. J Assist Reprod Genet 2000; 17 (4) 231-233
- 10 Bergère M, Lombroso R, Gombault M, Wainer R, Selva J. An idiopathic infertility with oocytes metaphase I maturation block: case report. Hum Reprod 2001; 16 (10) 2136-2138
- 11 Neal MS, Cowan L, Louis JP, Hughes E, King WA, Basrur PK. Cytogenetic evaluation of human oocytes that failed to complete meiotic maturation in vitro. Fertil Steril 2002; 77 (4) 844-845
- 12 Gulekli B, Olgan S, Aydiner F. In vitro oocyte maturation from unstimulated cycles: does it offer a realistic chance to overcome the problem of repeated oocyte maturation arrest in IVF?. Arch Gynecol Obstet 2011; 283 (Suppl. 01) 133-134
- 13 Heindryckx B, Lierman S, Combelles CM, Cuvelier CA, Gerris J, De Sutter P. Aberrant spindle structures responsible for recurrent human metaphase I oocyte arrest with attempts to induce meiosis artificially. Hum Reprod 2011; 26 (4) 791-800
- 14 Windt ML, Coetzee K, Kruger TF, Marino H, Kitshoff MS, Sousa M. Ultrastructural evaluation of recurrent and in-vitro maturation resistant metaphase I arrested oocytes. Hum Reprod 2001; 16 (11) 2394-2398
- 15 Rudak E, Dor J, Kimchi M, Goldman B, Levran D, Mashiach S. Anomalies of human oocytes from infertile women undergoing treatment by in vitro fertilization. Fertil Steril 1990; 54 (2) 292-296
- 16 Otsuki J, Momma Y, Takahashi K, Miyakura S, Nagai Y. Timed IVM followed by ICSI in a patient with immature ovarian oocytes. Reprod Biomed Online 2006; 13 (1) 101-103
- 17 Eichenlaub-Ritter U, Stahl A, Luciani JM. The microtubular cytoskeleton and chromosomes of unfertilized human oocytes aged in vitro. Hum Genet 1988; 80 (3) 259-264
- 18 Pickering SJ, Johnson MH, Braude PR, Houliston E. Cytoskeletal organization in fresh, aged and spontaneously activated human oocytes. Hum Reprod 1988; 3 (8) 978-989
- 19 Combelles CM, Morozumi K, Yanagimachi R, Zhu L, Fox JH, Racowsky C. Diagnosing cellular defects in an unexplained case of total fertilization failure. Hum Reprod 2010; 25 (7) 1666-1671
- 20 Mrazek M, Fulka Jr J. Failure of oocyte maturation: possible mechanisms for oocyte maturation arrest. Hum Reprod 2003; 18 (11) 2249-2252
- 21 Downs SM. Regulation of the G2/M transition in rodent oocytes. Mol Reprod Dev 2010; 77 (7) 566-585
- 22 Solc P, Schultz RM, Motlik J. Prophase I arrest and progression to metaphase I in mouse oocytes: comparison of resumption of meiosis and recovery from G2-arrest in somatic cells. Mol Hum Reprod 2010; 16 (9) 654-664
- 23 Holt JE, Jones KT. Control of homologous chromosome division in the mammalian oocyte. Mol Hum Reprod 2009; 15 (3) 139-147
- 24 Vogt E, Kirsch-Volders M, Parry J, Eichenlaub-Ritter U. Spindle formation, chromosome segregation and the spindle checkpoint in mammalian oocytes and susceptibility to meiotic error. Mutat Res 2008; 651 (1–2) 14-29
- 25 Wallbutton S, Kasraie J. Vacuolated oocytes: fertilization and embryonic arrest following intra-cytoplasmic sperm injection in a patient exhibiting persistent oocyte macro vacuolization—case report. J Assist Reprod Genet 2010; 27 (4) 183-188
- 26 Akarsu C, Cağlar G, Vicdan K, Sözen E, Biberoğlu K. Smooth endoplasmic reticulum aggregations in all retrieved oocytes causing recurrent multiple anomalies: case report. Fertil Steril 2009; 92 (4) 1496 , e1–e3
- 27 Stevenson TL, Lashen H. Empty follicle syndrome: the reality of a controversial syndrome, a systematic review. Fertil Steril 2008; 90 (3) 691-698
- 28 Swain JE, Pool TB. ART failure: oocyte contributions to unsuccessful fertilization. Hum Reprod Update 2008; 14 (5) 431-446
- 29 Javed M, Esfandiari N, Casper RF. Failed fertilization after clinical intracytoplasmic sperm injection. Reprod Biomed Online 2010; 20 (1) 56-67
- 30 Barroso G, Valdespin C, Vega E , et al. Developmental sperm contributions: fertilization and beyond. Fertil Steril 2009; 92 (3) 835-848
- 31 Mahutte NG, Arici A. Failed fertilization: is it predictable?. Curr Opin Obstet Gynecol 2003; 15 (3) 211-218
- 32 Bhattacharya S, Hamilton MP, Shaaban M , et al. Conventional in-vitro fertilisation versus intracytoplasmic sperm injection for the treatment of non-male-factor infertility: a randomised controlled trial. Lancet 2001; 357 (9274) 2075-2079
- 33 Flaherty SP, Payne D, Matthews CD. Fertilization failures and abnormal fertilization after intracytoplasmic sperm injection. Hum Reprod 1998; 13 (Suppl. 01) 155-164
- 34 Esfandiari N, Javed MH, Gotlieb L, Casper RF. Complete failed fertilization after intracytoplasmic sperm injection—analysis of 10 years' data. Int J Fertil Womens Med 2005; 50 (4) 187-192
- 35 Liu J, Nagy Z, Joris H , et al. Analysis of 76 total fertilization failure cycles out of 2732 intracytoplasmic sperm injection cycles. Hum Reprod 1995; 10 (10) 2630-2636
- 36 Gabrielsen A, Petersen K, Mikkelsen AL, Lindenberg S. Intracytoplasmic sperm injection does not overcome an oocyte defect in previous fertilization failure with conventional in-vitro fertilization and normal spermatozoa. Hum Reprod 1996; 11 (9) 1963-1965
- 37 Yanagida K. Complete fertilization failure in ICSI. Hum Cell 2004; 17 (4) 187-193
- 38 Khamsi F, Yavas Y, Roberge S, Wong JC, Lacanna IC, Endman M. Intracytoplasmic sperm injection increased fertilization and good-quality embryo formation in patients with non-male factor indications for in vitro fertilization: a prospective randomized study. Fertil Steril 2001; 75 (2) 342-347
- 39 van der Westerlaken L, Helmerhorst F, Dieben S, Naaktgeboren N. Intracytoplasmic sperm injection as a treatment for unexplained total fertilization failure or low fertilization after conventional in vitro fertilization. Fertil Steril 2005; 83 (3) 612-617
- 40 Bungum L, Bungum M, Humaidan P, Andersen CY. A strategy for treatment of couples with unexplained infertility who failed to conceive after intrauterine insemination. Reprod Biomed Online 2004; 8 (5) 584-589
- 41 Kastrop PM, Weima SM, Van Kooij RJ, Te Velde ER. Comparison between intracytoplasmic sperm injection and in-vitro fertilization (IVF) with high insemination concentration after total fertilization failure in a previous IVF attempt. Hum Reprod 1999; 14 (1) 65-69
- 42 Shveiky D, Simon A, Gino H , et al. Sibling oocyte submission to IVF and ICSI in unexplained infertility patients: a potential assay for gamete quality. Reprod Biomed Online 2006; 12 (3) 371-374
- 43 Sousa M, Tesarik J. Ultrastructural analysis of fertilization failure after intracytoplasmic sperm injection. Hum Reprod 1994; 9 (12) 2374-2380
- 44 Cheung A, Swann K, Carroll J. The ability to generate normal Ca(2+) transients in response to spermatozoa develops during the final stages of oocyte growth and maturation. Hum Reprod 2000; 15 (6) 1389-1395
- 45 Carroll J, Jones KT, Whittingham DG. Ca2+ release and the development of Ca2+ release mechanisms during oocyte maturation: a prelude to fertilization. Rev Reprod 1996; 1 (3) 137-143
- 46 Rybouchkin A, Dozortsev D, Pelinck MJ, De Sutter P, Dhont M. Analysis of the oocyte activating capacity and chromosomal complement of round-headed human spermatozoa by their injection into mouse oocytes. Hum Reprod 1996; 11 (10) 2170-2175
- 47 Tesarik J, Rienzi L, Ubaldi F, Mendoza C, Greco E. Use of a modified intracytoplasmic sperm injection technique to overcome sperm-borne and oocyte-borne oocyte activation failures. Fertil Steril 2002; 78 (3) 619-624
- 48 Heindryckx B, De Gheselle S, Gerris J, Dhont M, De Sutter P. Efficiency of assisted oocyte activation as a solution for failed intracytoplasmic sperm injection. Reprod Biomed Online 2008; 17 (5) 662-668
- 49 Heindryckx B, Van der Elst J, De Sutter P, Dhont M. Treatment option for sperm- or oocyte-related fertilization failure: assisted oocyte activation following diagnostic heterologous ICSI. Hum Reprod 2005; 20 (8) 2237-2241
- 50 Heytens E, Parrington J, Coward K , et al. Reduced amounts and abnormal forms of phospholipase C zeta (PLCzeta) in spermatozoa from infertile men. Hum Reprod 2009; 24 (10) 2417-2428
- 51 Cox LJ, Larman MG, Saunders CM, Hashimoto K, Swann K, Lai FA. Sperm phospholipase Czeta from humans and cynomolgus monkeys triggers Ca2+ oscillations, activation and development of mouse oocytes. Reproduction 2002; 124 (5) 611-623
- 52 Swann K, Saunders CM, Rogers NT, Lai FA. PLCzeta(zeta): a sperm protein that triggers Ca2+ oscillations and egg activation in mammals. Semin Cell Dev Biol 2006; 17 (2) 264-273
- 53 Rybouchkin AV, Van der Straeten F, Quatacker J, De Sutter P, Dhont M. Fertilization and pregnancy after assisted oocyte activation and intracytoplasmic sperm injection in a case of round-headed sperm associated with deficient oocyte activation capacity. Fertil Steril 1997; 68 (6) 1144-1147
- 54 Nasr-Esfahani MH, Deemeh MR, Tavalaee M. Artificial oocyte activation and intracytoplasmic sperm injection. Fertil Steril 2010; 94 (2) 520-526
- 55 Kashir J, Heindryckx B, Jones C, De Sutter P, Parrington J, Coward K. Oocyte activation, phospholipase C zeta and human infertility. Hum Reprod Update 2010; 16 (6) 690-703
- 56 Moaz MN, Khattab S, Foutouh IA, Mohsen EA. Chemical activation of oocytes in different types of sperm abnormalities in cases of low or failed fertilization after ICSI: a prospective pilot study. Reprod Biomed Online 2006; 13 (6) 791-794
- 57 Lu Q, Zhao Y, Gao X , et al. Combination of calcium ionophore A23187 with puromycin salvages human unfertilized oocytes after ICSI. Eur J Obstet Gynecol Reprod Biol 2006; 126 (1) 72-76
- 58 Borges Jr E, de Almeida Ferreira Braga DP, de Sousa Bonetti TC, Iaconelli Jr A, Franco Jr JG. Artificial oocyte activation with calcium ionophore A23187 in intracytoplasmic sperm injection cycles using surgically retrieved spermatozoa. Fertil Steril 2009; 92 (1) 131-136
- 59 Murase Y, Araki Y, Mizuno S , et al. Pregnancy following chemical activation of oocytes in a couple with repeated failure of fertilization using ICSI: case report. Hum Reprod 2004; 19 (7) 1604-1607
- 60 Nakagawa K, Yamano S, Moride N, Yamashita M, Yoshizawa M, Aono T. Effect of activation with Ca ionophore A23187 and puromycin on the development of human oocytes that failed to fertilize after intracytoplasmic sperm injection. Fertil Steril 2001; 76 (1) 148-152
- 61 Tesarik J, Sousa M. More than 90% fertilization rates after intracytoplasmic sperm injection and artificial induction of oocyte activation with calcium ionophore. Fertil Steril 1995; 63 (2) 343-349
- 62 Nasr-Esfahani MH, Razavi S, Javdan Z, Tavalaee M. Artificial oocyte activation in severe teratozoospermia undergoing intracytoplasmic sperm injection. Fertil Steril 2008; 90 (6) 2231-2237
- 63 Yanagida K, Morozumi K, Katayose H, Hayashi S, Sato A. Successful pregnancy after ICSI with strontium oocyte activation in low rates of fertilization. Reprod Biomed Online 2006; 13 (6) 801-806
- 64 Kyono K, Kumagai S, Nishinaka C , et al. Birth and follow-up of babies born following ICSI using SrCl2 oocyte activation. Reprod Biomed Online 2008; 17 (1) 53-58
- 65 Ebner T, Moser M, Sommergruber M, Jesacher K, Tews G. Complete oocyte activation failure after ICSI can be overcome by a modified injection technique. Hum Reprod 2004; 19 (8) 1837-1841
- 66 Yanagida K, Katayose H, Yazawa H , et al. Successful fertilization and pregnancy following ICSI and electrical oocyte activation. Hum Reprod 1999; 14 (5) 1307-1311
- 67 Baltaci V, Ayvaz OU, Unsal E , et al. The effectiveness of intracytoplasmic sperm injection combined with piezoelectric stimulation in infertile couples with total fertilization failure. Fertil Steril 2010; 94 (3) 900-904
- 68 Mansour R, Fahmy I, Tawab NA , et al. Electrical activation of oocytes after intracytoplasmic sperm injection: a controlled randomized study. Fertil Steril 2009; 91 (1) 133-139
- 69 Dam AH, Feenstra I, Westphal JR, Ramos L, van Golde RJ, Kremer JA. Globozoospermia revisited. Hum Reprod Update 2007; 13 (1) 63-75
- 70 Schmiady H, Schulze W, Scheiber I, Pfüller B. High rate of premature chromosome condensation in human oocytes following microinjection with round-headed sperm: case report. Hum Reprod 2005; 20 (5) 1319-1323
- 71 Kurokawa M, Sato K, Fissore RA. Mammalian fertilization: from sperm factor to phospholipase Czeta. Biol Cell 2004; 96 (1) 37-45
- 72 Yoon SY, Jellerette T, Salicioni AM , et al. Human sperm devoid of PLC, zeta 1 fail to induce Ca(2+) release and are unable to initiate the first step of embryo development. J Clin Invest 2008; 118 (11) 3671-3681
- 73 Rogers NT, Hobson E, Pickering S, Lai FA, Braude P, Swann K. Phospholipase Czeta causes Ca2+ oscillations and parthenogenetic activation of human oocytes. Reproduction 2004; 128 (6) 697-702
- 74 Ducibella T, Huneau D, Angelichio E , et al. Egg-to-embryo transition is driven by differential responses to Ca(2+) oscillation number. Dev Biol 2002; 250 (2) 280-291
- 75 Ozil JP, Banrezes B, Tóth S, Pan H, Schultz RM. Ca2+ oscillatory pattern in fertilized mouse eggs affects gene expression and development to term. Dev Biol 2006; 300 (2) 534-544
- 76 Schatten H, Sun QY. The role of centrosomes in mammalian fertilization and its significance for ICSI. Mol Hum Reprod 2009; 15 (9) 531-538
- 77 Nakamura S, Terada Y, Horiuchi T , et al. Analysis of the human sperm centrosomal function and the oocyte activation ability in a case of globozoospermia, by ICSI into bovine oocytes. Hum Reprod 2002; 17 (11) 2930-2934
- 78 Chemes HE, Puigdomenech ET, Carizza C, Olmedo SB, Zanchetti F, Hermes R. Acephalic spermatozoa and abnormal development of the head-neck attachment: a human syndrome of genetic origin. Hum Reprod 1999; 14 (7) 1811-1818
- 79 Rawe VY, Terada Y, Nakamura S, Chillik CF, Olmedo SB, Chemes HE. A pathology of the sperm centriole responsible for defective sperm aster formation, syngamy and cleavage. Hum Reprod 2002; 17 (9) 2344-2349
- 80 Van Blerkom J. Sperm centrosome dysfunction: a possible new class of male factor infertility in the human. Mol Hum Reprod 1996; 2 (5) 349-354
- 81 Terada Y, Schatten G, Hasegawa H, Yaegashi N. Essential roles of the sperm centrosome in human fertilization: developing the therapy for fertilization failure due to sperm centrosomal dysfunction. Tohoku J Exp Med 2010; 220 (4) 247-258
- 82 Nakamura S, Terada Y, Horiuchi T , et al. Human sperm aster formation and pronuclear decondensation in bovine eggs following intracytoplasmic sperm injection using a Piezo-driven pipette: a novel assay for human sperm centrosomal function. Biol Reprod 2001; 65 (5) 1359-1363
- 83 Terada Y. Human sperm centrosomal function during fertilization, a novel assessment for male sterility. Hum Cell 2004; 17 (4) 181-186
- 84 Bartoov B, Berkovitz A, Eltes F , et al. Pregnancy rates are higher with intracytoplasmic morphologically selected sperm injection than with conventional intracytoplasmic injection. Fertil Steril 2003; 80 (6) 1413-1419
- 85 Ugajin T, Terada Y, Hasegawa H, Nabeshima H, Suzuki K, Yaegashi N. The shape of the sperm midpiece in intracytoplasmic morphologically selected sperm injection relates sperm centrosomal function. J Assist Reprod Genet 2010; 27 (2–3) 75-81
- 86 Terada Y, Hasegawa H, Takahashi A, Ugajin T, Yaegashi N, Okamura K. Successful pregnancy after oocyte activation by a calcium ionophore for a patient with recurrent intracytoplasmic sperm injection failure, with an assessment of oocyte activation and sperm centrosomal function using bovine eggs. Fertil Steril 2009; 91 (3) 935-, e11–e14
- 87 Nakamura S, Terada Y, Rawe VY , et al. A trial to restore defective human sperm centrosomal function. Hum Reprod 2005; 20 (7) 1933-1937
- 88 Comizzoli P, Wildt DE, Pukazhenthi BS. Poor centrosomal function of cat testicular spermatozoa impairs embryo development in vitro after intracytoplasmic sperm injection. Biol Reprod 2006; 75 (2) 252-260
- 89 Rawe VY, Díaz ES, Abdelmassih R , et al. The role of sperm proteasomes during sperm aster formation and early zygote development: implications for fertilization failure in humans. Hum Reprod 2008; 23 (3) 573-580
- 90 Chemes HE, Rawe VY. The making of abnormal spermatozoa: cellular and molecular mechanisms underlying pathological spermiogenesis. Cell Tissue Res 2010; 341 (3) 349-357
- 91 Combelles CM, Kearns WG, Fox JH, Racowsky C. Cellular and genetic analysis of oocytes and embryos in a human case of spontaneous oocyte activation. Hum Reprod 2011; 26 (3) 545-552
- 92 Xing X, Zhao H, Li M, Sun M, Li Y, Chen ZJ. Morphologically abnormal oocytes not capable of fertilization despite repeated strategies. Fertil Steril 2011; 95 (7) 2435 , e5–e7
- 93 Matt DW, Ingram AR, Graff DP, Edelstein MC. Normal birth after single-embryo transfer in a patient with excessive polypronuclear zygote formation following in vitro fertilization and intracytoplasmic sperm injection. Fertil Steril 2004; 82 (6) 1662-1665
- 94 Ryley DA, Wu HH, Leader B, Zimon A, Reindollar RH, Gray MR. Characterization and mutation analysis of the human formin-2 (FMN2) gene in women with unexplained infertility. Fertil Steril 2005; 83 (5) 1363-1371
- 95 Avenarius MR, Hildebrand MS, Zhang Y , et al. Human male infertility caused by mutations in the CATSPER1 channel protein. Am J Hum Genet 2009; 84 (4) 505-510
- 96 Bungum M, Giwercman A, Bungum L, Humaidan P, Rastkhani H, Giwercman YL. Polymorphisms in the protein C inhibitor gene in in vitro fertilization failure. Fertil Steril 2010; 93 (1) 277-279
- 97 Hildebrand MS, Avenarius MR, Fellous M , et al. Genetic male infertility and mutation of CATSPER ion channels. Eur J Hum Genet 2010; 18 (11) 1178-1184
- 98 Gasca S, Reyftmann L, Pellestor F , et al. Total fertilization failure and molecular abnormalities in metaphase II oocytes. Reprod Biomed Online 2008; 17 (6) 772-781