Exp Clin Endocrinol Diabetes 2012; 120(04): 194-196
DOI: 10.1055/s-0032-1304580
Mini-Review Series on Diabetes and its Complications
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Macrovascular Disease in Diabetes: Is the Mouse a Suitable Model?

O. J. Müller
1   Department of Cardiology, UniversityHospital, Heidelberg, Germany
,
H. A. Katus
1   Department of Cardiology, UniversityHospital, Heidelberg, Germany
,
J. Backs
1   Department of Cardiology, UniversityHospital, Heidelberg, Germany
› Author Affiliations
Further Information

Publication History

received 30 January 2012
first decision 30 January 2012

accepted 31 January 2012

Publication Date:
08 March 2012 (online)

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Abstract

To elucidate the pathogenesis of macrovascular disease in diabetes, animal models are widely used. Diabetic mice are of particular interest because they can be crossed to knockout mice lacking specific genes that are under consideration to contribute to diabetic vascular complications. However, the mouse is relative resistant to develop atherosclerosis. Therefore, we review some commonly used mouse models and discuss their advantages and disadvantages.