Planta Med 2012; 78(09): 906-908
DOI: 10.1055/s-0031-1298537
Biological and Pharmacological Activity
Letters
Georg Thieme Verlag KG Stuttgart · New York

Leishmanicidal Compounds from the Fruits of Piper longum

Sabari Ghosal
1   Amity Institute of Biotechnology, Amity University, Noida, India
,
Anindita Deb
2   Department of Bioorganic Chemistry, National Institute of Immunology, New Delhi, India
,
Priyanka Mishra
1   Amity Institute of Biotechnology, Amity University, Noida, India
,
Ram Vishwakarma
2   Department of Bioorganic Chemistry, National Institute of Immunology, New Delhi, India
› Author Affiliations
Further Information

Publication History

received 01 March 2012
revised 12 April 2012

accepted 16 April 2012

Publication Date:
10 May 2012 (online)

Preview

Abstract

One new alkaloid amide, piperlongumide (1) [N-isobutyl-19-(3′,4′-methylenedioxyphenyl)-2E,4E nonadecadienamide], and six known compounds with leishmanicidal activity against promastigotes and axenic amastigotes of Leishmania donovani were isolated from the n-hexane fraction of the fruits of Piper longum. The structure of 1 was elucidated by spectroscopic evidences.