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DOI: 10.1055/s-0031-1298322
© Georg Thieme Verlag KG Stuttgart · New York
Carboline Alkaloids from Psammosilene tunicoides and Their Cytotoxic Activities
Publication History
received October 20, 2011
revised January 22, 2012
accepted February 6, 2012
Publication Date:
12 March 2012 (online)

Abstract
Five new carboline alkaloids, tunicoidines A–E (1–5), and two known carboline alkaloids, 1-acetyl-β-carboline-3-carboxylic acid (6) and 1-acetyl-3-carbomethoxyl-β-carboline (7), were isolated for the first time from the root of Psammosilene tunicoides. The structures of the new carboline alkaloids were established on the basis of 1D- and 2D-NMR, and HR-MS spectroscopic analyses. The seven compounds were evaluated for cytotoxicity against A549, HCT116, ZR-75-30, and HL-60 cell lines. However, only compound 7 had potent cytotoxic activity against the HCT116 cell line with an IC50 value of 9.67 µg/mL, while the others showed no cytotoxic activities against the four tested cell lines.
Key words
Psammosilene tunicoides - Caryophyllaceace - carboline alkaloids - cytotoxic activities
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Dr. Weidong Zhang
Department of Phytochemistry
School of Pharmacy
Second Military Medical University
325# Guohe Rd.
Shanghai 200433
P. R. China
Phone: +86 21 81 87 12 44
Fax: +86 21 81 87 12 44
Email: wdzhangy@hotmail.com
Dr. Yunheng Shen
Department of Phytochemistry
School of Pharmacy
Second Military Medical University
325# Guohe Rd.
Shanghai 200433
P. R. China
Phone: +86 21 81 87 12 45
Fax: +86 21 81 87 12 45
Email: shenyunheng9217018@yahoo.com.cn