Cytotoxic Triterpenoid Saponins from Ardisia gigantifolia

Abstract

Three new triterpenoid saponins, 1–3, together with two known saponins, 4 and 5, were isolated from the rhizome of Ardisia gigantifolia. Their structures were elucidated by 1D and 2D NMR spectroscopic studies. Saponins 1, 2, 4, and 5 exhibited significant cytotoxicity against four human cancer cell lines, namely, Hela human cervical carcinoma cells, EJ human bladder tumor cells, HepG-2 human hepatoma cells, and BCG human gastric carcinoma cells with IC₅₀ values in the range of 1.9–4.8 µM.

Key words

Ardisia gigantifolia - Myrsinaceae - triterpenoid saponin - cytotoxic activity

References

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1 These authors contributed equally to this work.