Funktionserhalt nach der Therapie von Kopf-Hals-Tumoren

Zusammenfassung

Der Funktionserhalt ist ein wesentlicher Aspekt in der Beurteilung von Therapieverfahren bei malignen Kopf-Hals-Tumoren. Ein Erhalt anatomischer Strukturen kann nicht automatisch mit einem Erhalt von Körperfunktionen gleich gesetzt werden. Insbesondere bei der Beurteilung von unterschiedlichen Therapieverfahren mit ähnlich guten onkologischen Ergebnissen treten funktionelle Aspekte zunehmend in den Fokus.

Aktuelle Studien berücksichtigen deshalb 3 Themenbereiche mit variablen Schwerpunkten: (1) die Effekte der Krebsbehandlung auf lebenswichtige Körperfunktionen, (2) zusätzliche Therapie-bedingte Nebenwirkungen und Komplikationen und (3) die Lebensqualität der Betroffenen.

Die vorliegende Arbeit fasst wesentliche Ergebnisse der klinischen Forschung der letzten Jahre zusammen. Die funktionellen Ergebnisse nach chirurgischen und nicht-chirurgischen Therapieverfahren werden Lokalisations- und Staging- spezifisch dargestellt. Abschließend werden methodische Aspekte der Datenerfassung und Dokumentation ebenso wie Herausforderungen bei der Umsetzung in der klinischen Praxis diskutiert.

Abstract

Preservation of Organ Function in Head and Neck Cancer▼

Preservation of function is a crucial aspect for the evaluation of therapies applied in the field of head and neck cancer. However, preservation of anatomic structures does not equalize preservation of function. Particularly for the evaluation of alternative treatment options with equivalent oncologic outcome functional outcome becomes increasingly important.

Present studies collect with varying emphasize (1) the effects of therapy on essential body functions, (2) additional therapy-induced toxic effects, and (3) health-related quality of life. The present article summarizes vital aspects of clinical research from the last years. Preservation of function after surgical and non-surgical treatment approaches are presented according to tumour localisation and staging criteria.

Additional methodological aspects of study design and documentation as well as challenges and present activities for the transformation into clinical practise are discussed.

Schlüsselwörter

Kopf-Hals-Tumore - Mundhöhlenkarzinom - Oropharynxkarzinom - Larynxkarzinom - Organerhalt - Toxizität - Lebensqualität - Funktionsfähigkeit

Key words

head neck cancer - oral cancer - oropharyngeal cancer - laryngeal cancer - organ preservation - toxicity - quality of life - rehabilitation

• Literatur

• 1 Haas I, Hauser U, Ganzer U. The dilemma of follow-up in head and neck cancer patients. Eur Arch Otorhinolaryngol 2001; 258 (04) 258
• 2 World Health Organization . ICF – International Classification of Functioning, Disability and Health. 2001. Geneva:
• 3 Oskam I, Verdonck-de Leeuw I, Aaronson N, Kuik D, de Bree R, Doornaert P et al. Quality of life as predictor of survival: a prospective study on patients treated with combined surgery and radiotherapy for advanced oral and oropharyngeal cancer. Radiother Oncol 2010; Nov. 97 (02) 258-262
• 4 MacKenzie R, Franssen E, Balogh J, Birt D, Gilbert R. The prognostic significance of tracheostomy in carcinoma of the larynx treated with radiotherapy and surgery for salvage. Int J Radiat Oncol Biol Phys 1998; 1; 41 (01) 43-51
• 5 Nordgren M, Hammerlid E, Bjordal K, Ahlner-Elmqvist M, Boysen M, Jannert M. Quality of life in oral carcinoma: a 5-year prospective study. Head Neck Apr 2008; 30 (04) 461-470
• 6 Korfage A, Schoen P, Raghoebar G, Bouma J, Burlage F, Roodenburg J et al. Five-year follow-up of oral functioning and quality of life in patients with oral cancer with implant-retained mandibular overdentures. Head Neck Jun 2011; 33 (06) 831-839
• 7 Gabler Verlag H. Gabler Wirtschaftslexikon, Stichwort: gesundheitsbezogene Lebensqualität. ,. online im Internet http://wirtschaftslexikon.gabler.de/Archiv/18103/gesundheitsbezogene-lebensqualitaet-v9.html 2011
• 8 Jacobi I, van der Molen L, Huiskens H, van Rossum M, Hilgers F. Voice and speech outcomes of chemoradiation for advanced head and neck cancer: a systematic review. Eur Arch Otorhinolaryngol 2010; 267 (10) 1495-1505
• 9 Kreeft A, van der Molen L, Hilgers F, Balm A. Speech and swallowing after surgical treatment of advanced oral and oropharyngeal carcinoma: a systematic review of the literature. Eur Arch Otorhinolaryngol 2009; 266 (11) 1687-1698
• 10 van der Molen L, van Rossum MA, Ackerstaff AH, Smeele LE, Rasch CR, Hilgers FJ. Pretreatment organ function in patients with advanced head and neck cancer: clinical outcome measures and patients’ views. BMC Ear Nose Throat Disord 2009; 9: 10
• 11 Kanatas A, Rogers S. A systematic review of patient self-completed questionnaires suitable for oral and maxillofacial surgery. Br J Oral Maxillofac Surg 2010; 48 (08) 579-590
• 12 Rogers S, Ahad S, Murphy A. A structured review and theme analysis of papers published on “Quality of life” in Head and Neck Cancer: 2000 to 2005. Oral Oncology 2007; 43 (09) 843-868
• 13 van der Molen L, van Rossum MA, Burkhead LM, Smeele LE, Hilgers FJ. Functional outcomes and rehabilitation strategies in patients treated with chemoradiotherapy for advanced head and neck cancer: a systematic review. Eur Arch Otorhinolaryngol 2009; 266 (06) 901-902
• 14 Radiation Therapy Oncology Group, R., http://www.rtog.org/ResearchAssociates/AdverseEventReporting/AcuteRadiationMorbidity­ScoringCriteria.aspx
• 15 Trotti A, Colevas A, Setser A. CTCAE: development of a comprehensive grading system for the adverse effects of cancer treatment. Semin Radiat Oncol 2003; 13: 176-181
• 16 Maguire P, Papagikos M, Hamann S, Neal C, Meyerson M, Hayes N et al. Phase II trial of hyperfractionated intensity-modulated radiation therapy and concurrent weekly cisplatin for Stage III and IVa head-and-neck cancer. Int J Radiat Oncol Biol Phys 2011; 79 (04) 1081-1088
• 17 Givens D, Karnell L, Gupta A, Clamon G, NA P, Chang K et al. Adverse events associated with concurrent chemoradiation therapy in patients with head and neck cancer. Arch Otolaryngol Head Neck Surg 2009; 135 (12) 1209-1217
• 18 Dietz A, Rudat V, Dreyhaupt J, Pritsch M, Hoppe F, Hagen R et al. Induction chemotherapy with paclitaxel and cisplatin followed by radiotherapy for larynx organ preservation in advanced laryngeal and hypopharyngeal cancer offers moderate late toxicity outcome (DeLOS-I-trial). Eur Arch Otorhinolaryngol 2009; 266 (08) 1291-1300
• 19 n/a, Late Effects of Normal Tissues (LENT) Consensus Conference. Lent soma scales for all anatomic sites. International Journal of Radiation Oncol Biol Phys 1995; 31 (05) 1049-1091
• 20 Ho K, Farnell D, Routledge J, Burns M, Sykes A, Slevin N et al. Comparison of patient-reported late treatment toxicity (LENT-SOMA) with quality of life (EORTC QLQ-C30 and QLQ-H&N35) assessment after head and neck radiotherapy. Radiother Oncol Nov 2010; 97 (02) 270-275
• 21 Seidl R, Nusser-Müller-Busch R, Ernst A. Evaluation eines Untersuchungsbogens zur endoskopischen Schluckuntersuchung. Sprache Stimme Gehör 2002; 26: 28-36
• 22 Rosenbek J, Robbins J, Roecker E, Coyle J, Wood J. A penetration-aspiration scale. Dysphagia 1996; 11: 93-98
• 23 Logemann J. Manual for the videofluorographic study of swallowing. 2^nd ed. Pro-Ed. 1993. Austin, TX: 170
• 24 Schneider B, Wendler J, Seidner W. The relevance of stroboscopy in functional dysphonias(1). Folia Phoniatr Logop 2002; 54 (01) 44-54
• 25 Laugsand E, Sprangers M, Bjordal K, Skorpen F, Kaasa S, Klepstad P. Health care providers underestimate symptom intensities of cancer patients: a multicenter European study. Health Qual Life Outcomes 2010; 21 (08) 104
• 26 Weymuller EJ, Yueh B, Deleyiannis F, Kuntz A, Alsarraf R, Coltrera M. Quality of life in head and neck cancer. Laryngoscope 2000; 110 (3 suppl) 4-7
• 27 Dietz A, Meyer A, Singer S. Measuring quality of life in head and neck cancer. Current status and future needs. HNO 2009; 57 (09) 857-865
• 28 Mapi reserach institute . ProQuolid: patient reported outcome and quality of life instruments database. 2010;
• 29 Bjordal K, Hammerlid E, Ahlner-Elmqvist M, de Graeff A, Boysen M, Evensen J et al. Quality of life in head and neck cancer patients: validation of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-H&N35. J Clin Oncol 1999; 17 (03) 1008-1019
• 30 Cella DF, Tulsky DS, Gray G, Sarafian B, Linn E, Bonomi A et al. The Functional Assessment of Cancer Therapy scale: development and validation of the general measure. J Clin Oncol 1993; 11 (03) 570-579
• 31 Rogers SN, Gwanne S, Lowe D, Humphris G, Yueh B, Weymuller Jr EA. The addition of mood and anxiety domains to the University of Washington quality of life scale. Head Neck 2002; 24 (06) 521-529
• 32 Nawka T, Wiesmann U, Gonnermann U. Validierung des Voice Handicap Index (VHI) in der deutschen Fassung. HNO 2003; 51: 921-929
• 33 Hogikyan N, Sethuraman G. Validation of an Instrument to Measure Voice-Related Quality of Life (V-RQOL). J Voice 1999; 13 (04) 557-569
• 34 Bauer F, Seiss M, Grässel E, Stelzle F, Klotz M, Rosanowski F. Swallowing-related quality of life in oral cavity cancer. The German version of the Anderson Dysphagia Inventory. HNO Jul 2010; 58 (07) 692-697
• 35 Cleeland C, Ryan K. Pain assessment: global use of the Brief Pain Inventory. Ann Acad Med Singapore 1994; 23 (02) 129-138
• 36 Melzack R. The McGill Pain Questionnaire: major properties and scoring methods 1975; 1: 277-299
• 37 Sadura A, Pater J, Osoba D, Palmer LMM, Bennett K. Quality-of-life assessment: patient compliance with questionnaire completion. J Natl Cancer Inst 1992; 84 (13) 1023-1026
• 38 Arbeitsgemeinschaft Psychoonkologie . Herschbach P, Weis J. Secreeningverfahren in der Psychoonkologie. Testinstrumente zur Identifikation betreuungsbedürftiger Krebspatienten. Eine Empfehlung der PSO. Deutsche Krebsgesellschaft 2008;
• 39 Tschiesner U, Rogers SN, Harreus U, Berghaus A, Cieza A. Content comparison of quality of life questionnaires used in head and neck cancer based on the international classification of functioning, dis­ability and health: a systematic review. Eur Arch Otorhinolaryngol 2008; 265 (06) 627-637
• 40 van der Molen L, van Rossum MA, Burkhead LM, Smeele LE, Hilgers FJ. Functional outcomes and rehabilitation strategies in patients treated with chemoradiotherapy for advanced head and neck cancer: a systematic review. Eur Arch Otorhinolaryngol 2009; 266 (06) 889-900
• 41 Stelzle F, Maier A, Nöth E, Bocklet T, Knipfer C, Schuster M et al. Automatic quantification of speech intelligibility in patients after treatment for oral squamous cell carcinoma. J Oral Maxillofac Surg May 2011; 69 (05) 1493-1500
• 42 Suarez-Cunqueiro M, Schramm A, Schoen R, Seoane-Lestón J, Otero-Cepeda X, Bormann K et al. Speech and swallowing impairment after treatment for oral and oropharyngeal cancer. Arch Otolaryngol Head Neck Surg Dec 2008; 134 (12) 1299-1304
• 43 Brown J, Rogers S, Lowe D. A comparison of tongue and soft palate squamous cell carcinoma treated by primary surgery in terms of survival and quality of life outcomes. Int J Oral Maxillofac Surg Mar 2006; 35 (03) 208-214
• 44 Kreeft A, van der Molen L, Hilgers FJ BA. Speech and swallowing after surgical treatment of advanced oral and oropharyngeal carcinoma: a systematic review of the literature. Eur Arch Otorhinolaryngol Nov 2009; 266 (11) 1687-1698
• 45 Speksnijder C, van der Bilt A, Abbink J, Merkx M, Koole R. Mastication in patients treated for malignancies in tongue and/or floor of mouth: A 1-year prospective study. Head Neck Jul 2011; 33 (07) 1013-1020
• 46 Hahn T, Krüskemper G. The impact of radiotherapy on quality of life – a survey of 1411 patients with oral cancer. Mund Kiefer Gesichtschir Apr 2007; 11 (02) 99-106
• 47 van Rij C, Oughlane-Heemsbergen W, Ackerstaff A, Lamers E, Balm A, Rasch C. Parotid gland sparing IMRT for head and neck cancer improves xerostomia related quality of life. Radiat Oncol Dec 9 2008; 3: 41
• 48 Givens D, Karnell L, Gupta A, Clamon G, Pagedar N, Chang K et al. Adverse events associated with concurrent chemoradiation therapy in patients with head and neck cancer. Arch Otolaryngol Head Neck Surg Dec 2009; 135 (12) 1209-1217
• 49 Wan Leung S, Lee T, Chien C, Chao P, Tsai W, Fang F. Health-related quality of life in 640 head and neck cancer survivors after radiotherapy using EORTC QLQ-C30 and QLQ-H&N35 questionnaires. BMC Cancer Apr 2011; 12 (11) 128
• 50 Caglar H, Tishler R, Othus M, Burke E, Li Y, Goguen L et al. Dose to larynx predicts for swallowing complications after intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys Nov 15 2008; 72 (04) 1110-1118
• 51 Peponi E, Glanzmann C, Willi B, Huber G, Studer G. Dysphagia in head and neck cancer patients following intensity modulated radiotherapy (IMRT). Radiat Oncol Jan 5 2011; 6: 1
• 52 Weber C, Dommerich S, Pau H, Kramp B. Limited mouth opening after primary therapy of head and neck cancer. Oral Maxillofac Surg Sep 2010; 14 (03) 169-173
• 53 Bensadoun R, Riesenbeck D, Lockhart P, Elting L, Spijkervet F, Brennan M. A systematic review of trismus induced by cancer therapies in head and neck cancer patients. Support Care Cancer Aug 2010; 18 (08) 1033-1038 [Epub 2010 Mar 6]
• 54 Browman GP, Hodson DI, Mackenzie RJ, Bestic N, Zuraw L. Choosing a concomitant chemotherapy and radiotherapy regimen for squamous cell head and neck cancer: A systematic review of the published literature with subgroup analysis. Head Neck 2001; 23 (07) 579-589
• 55 Pignon JP, Bourhis J, Domenge C, Designe L. Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. MACH-NC Collaborative Group. Meta-Analysis of Chemotherapy on Head and Neck Cancer Lancet 2000; 355 (9208) 949-955
• 56 Boscolo-Rizzo P, Muzzi E, Trabalzini F, Gava A, Stellin M, Da Mosto M. Functional organ preservation after chemoradiotherapy in elderly patients with loco-regionally advanced head and neck squamous cell carcinoma. Eur Arch Otorhinolaryngol Jan 22 2011;
• 57 Boscolo-Rizzo P, Gava A, Marchiori C, Baggio V, Da Mosto M. Functional organ preservation in patients with locoregionally advanced head and neck squamous cell carcinoma treated by platinum-based multidrug induction chemotherapy and concurrent chemoradiotherapy. Ann Oncol Aug 2011; 22 (08) 1894-1901 [Epub 2011 Jan 27]
• 58 Semrau S, Waldfahrer F, Lell M, Linke R, Klautke G, Kuwert T et al. Feasibility, toxicity, and efficacy of short induction chemotherapy of docetaxel plus cisplatin or carboplatin (TP) followed by concurrent chemoradio-therapy for organ preservation in advanced cancer of the hypopharynx, larynx, and base of tongue. Early results. Strahlenther Onkol Jan 2011; 187 (01) 15-22 [Epub 2010 Dec 22]
• 59 Al-Salel K, Safwat R, Hooda H, Bedair A, Al-Basmy A, Al-Wikeel H et al. Hyperfractionated Radiation Theraphy and Concurrent Chemotheraphy for advanced Head and Neck Cancer. Gulf J Oncolog Jan 2011; 1 (09) 12-19
• 60 Lambertz C, Gruell J, Robenstein V, Mueller-Funaiole V, Cummings K, Knapp V. No SToPS: Reducing treatment breaks during chemoradiation for head and neck cancer. Clin J Oncol Nurs Oct 1 2010; 14 (05) 585-593
• 61 Bonner J, Harari P, Giralt J, Azarnia N, Shin D, Cohen R et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med Feb 9 2006; 354 (06) 567-578
• 62 Walsh L, Gillham C, Dunne M, Fraser I, Hollywood D, Armstrong J et al. Toxicity of cetuximab versus cisplatin concurrent with radiotherapy in locally advanced head and neck squamous cell cancer (LAHNSCC). Radiother Oncol Jan 2011; 98 (01) 38-41
• 63 Kies M, Holsinger F, Jj L, William WJ, Glisson B, Lin H et al. Induction chemotherapy and cetuximab for locally advanced squamous cell carcinoma of the head and neck: results from a phase II prospective trial. J Clin Oncol, Jan 1 2010; 28 (01) 8-14
• 64 Scarpace S, Brodzik F, Mehdi S, Belgam R. Treatment of head and neck cancers: issues for clinical pharmacists. Pharmacotherapy May 2009; 29 (05) 578-592
• 65 Budach W, Bölke E, Homey B. Severe cutaneous reaction during radiation therapy with concurrent cetuximab. N Engl J Med Aug 2 2007; 357 (05) 514-515
• 66 Pinto C, Barone C, Girolomoni G, Russi E, Merlano M, Ferrari D et al. Management of skin toxicity associated with cetuximab treatment in combination with chemotherapy or radiotherapy. Oncologist 2011; 16 (02) 228-238 [Epub 2011 Jan 27]
• 67 Montejo M, Shrieve D, Bentz B, Hunt J, Buchman L, Agarwal N et al. IMRT With Simultaneous Integrated Boost and Concurrent Chemotherapy for Locoregionally Advanced Squamous Cell Carcinoma of the Head and Neck. Int J Radiat Oncol Biol Phys 2011; [Epub ahead of print]
• 68 Furness S, Glenny A, Worthington H, Pavitt S, Oliver R, Clarkson J. et al. Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy. Cochrane Database Syst Rev Apr 13 2011; (04) CD006386. Review
• 69 Argiris A, Heron D, Smith R, Kim S, Gibson M, Lai S et al. Induction docetaxel, cisplatin, and cetuximab followed by concurrent radiotherapy, cisplatin, and cetuximab and maintenance cetuximab in patients with locally advanced head and neck cancer. J Clin Oncol Dec 20 2010; 28 (36) 5294-5300
• 70 Villaret AB, Cappiello J, Piazza C, Pedruzzi B, Nicolai P. Quality of life in patients treated for cancer of the oral cavity requiring reconstruction: a prospective study. Acta Otorhinolaryngol Ital 2008; 28 (03) 120-125
• 71 Biazevic M, Antunes J, Togni J, de Andrade F, de Carvalho M, Wünsch-Filho V. Survival and quality of life of patients with oral and oropharyngeal cancer at 1-year follow-up of tumor resection. J Appl Oral Sci May-Jun 2010; 18 (03) 279-284
• 72 Borggreven P, Aaronson N, Verdonck-de Leeuw I, Muller M, Heiligers M, Bree R et al. Quality of life after surgical treatment for oral and oropharyngeal cancer: a prospective longitudinal assessment of patients reconstructed by a microvascular flap. Oral Oncol Nov 2007; 43 (10) 1034-1042 [Epub 2007 Feb 16]
• 73 Brown L, Rieger J, Harris J, Seikaly H. A longitudinal study of functional outcomes after surgical resection and microvascular reconstruction for oral cancer: tongue mobility and swallowing function. J Oral Maxillofac Surg Nov 2010; 68 (11) 2690-2700
• 74 Bozec A, Poissonnet G, Chamorey E, Casanova C, Vallicioni J, Demard F et al. Free-flap head and neck reconstruction and quality of life: a 2-year prospective study. Laryngoscope 2008; 118 (05) 874-880
• 75 Yanai C, Kikutani T, Adachi M, Thoren H, Suzuki M LT Functional outcome after total and subtotal glossectomy with free flap reconstruction. Head Neck 2008; Jul; 30 (07) 909-918
• 76 Archontaki M, Athanasiou A, Stavrianos S, Korkolis D, Faratzis G, Papadopoulou F et al. Functional results of speech and swallowing after oral microvascular free flap reconstruction. Eur Arch Otorhinolaryngol Nov 2010; 267 (11) 1771-1777 [Epub 2010 May 21]
• 77 Moerman M, Vermeersch H, Van Lierde K, Fahimi H, Van Cauwenberge P. Refinement of the free radial forearm flap reconstructive technique after resection of large oropharyngeal malignancies with excellent functional results. Head Neck Sep 2003; 25 (09) 772-777
• 78 Roumanas E, Garrett N, Blackwell K, Freymiller E, Abemayor E, Wong W et al. Masticatory and swallowing threshold performances with conventional and implant-supported prostheses after mandibular fibula free-flap reconstruction. J Prosthet Dent Oct 2006; 96 (04) 289-297
• 79 Baumann D, Yu P, Hanasono M, Skoracki R. Free flap reconstruction of osteoradionecrosis of the mandible: a 10-year review and defect classification. Head Neck Jun 2011; 33 (06) 800-807
• 80 Hsiao H, Leu Y, Liu C, Tung K, Lin C. Radial forearm versus anterolateral thigh flap reconstruction after hemiglossectomy: functional assessment of swallowing and speech. J Reconstr Microsurg Feb 2008; 24 (02) 85-88
• 81 Rizvi TA, Rashid M, Ahmed B, Haq EU, Sarwar SU, Zia-ul-Islam M et al. Quality of life assessment in patients with locally advanced head and neck malignancy after ablative surgery and reconstruction with microvascular free flaps. J Coll Physicians Surg Pak 2009; 19 (02) 108-112
• 82 Chung M, Son Y, Cho J, So Y, Woo S, Jeong H et al. Therapeutic options in patients with early T stage and advanced N stage of tonsillar squamous cell carcinomas. Otolaryngol Head Neck Surg Dec 2010; 143 (06) 808-814 [Epub 2010 Oct 20]
• 83 Gan H, Bernstein L, Brown J, Ringash J, Vakilha M, Wang L et al. Cognitive Functioning After Radiotherapy or Chemoradiotherapy for Head-and-Neck Cancer. Int J Radiat Oncol Biol Phys Sep 1 2011; 81 (01) 126-134
• 84 Hsiao K, Yeh S, Chang C, Tsai P, Wu J, Gau J. Cognitive function before and after intensity-modulated radiation therapy in patients with nasopharyngeal carcinoma: a prospective study. Int J Radiat Oncol Biol Phys Jul 1 2010; 77 (03) 722-726
• 85 Mowry S, Ho A, Lotempio M, Sadeghi A, Blackwell K, Wang M. Quality of life in advanced oropharyngeal carcinoma after chemoradia­tion versus surgery and radiation. Laryngoscope Sep 2006; 116 (09) 1589-1593
• 86 Kim T, Youm Y, Byun H, Son Y, Baek C. Treatment Outcomes and Quality of Life in Oropharyngeal Cancer after Surgery-based versus Radiation-based Treatment. Clin Exp Otorhinolaryngol Sep 2010; 3 (03) 153-160
• 87 Ambrosch P, Fazel A. Functional organ preservation in laryngeal and hypopharyngeal cancer. Laryngorhinootologie Mar 2011; 90 (Suppl. 01) S83-S109
• 88 Kujath M, Kerr P, Myers C, Bammeke F, Lambert P, Cooke A et al. Functional outcomes and laryngectomy-free survival after transoral CO□ laser microsurgery for stage 1 and 2 glottic carcinoma. J Otolaryngol Head Neck Surg 2011; 40 (Suppl. 01) S49-S58
• 89 Núñez Batalla F, Caminero Cueva M, Señaris González B, Llorente Pendás J, Gorriz Gil J, López Llames A et al. Voice quality after endoscopic laser surgery and radiotherapy for early glottic cancer: objective measurements emphasizing the Voice Handicap Index. Eur Arch Otorhinolaryngol May 2008; 265 (05) 543-548 [Epub 2007 Nov 13]
• 90 Loughran S, Calder N, MacGregor F, Carding P, MacKenzie K. Quality of life and voice following endoscopic resection or radiotherapy for early glottic cancer. Clin Otolaryngol 2005; 30 (01) 42-47
• 91 Spielmann P, Majumdar S, Morton R. Quality of life and functional outcomes in the management of early glottic carcinoma: a systematic review of studies comparing radiotherapy and transoral laser microsurgery. Clin Otolaryngol Oct 2010; 35 (05) 373-382
• 92 Mostafa B, Youssef A. Conservation surgery for early laryngeal carcinoma. ORL J Otorhinolaryngol Relat Spec 2010; 72 (04) 220-224
• 93 Webster K, Samlan R, Jones B, Bunton K, Tufano R. Supracricoid partial laryngectomy: swallowing, voice, and speech outcomes. Ann Otol Rhinol Laryngol 2010; 119 (01) 10-16
• 94 Saito K, Araki K, Ogawa K, Shiotani A. Laryngeal function after supracricoid laryngectomy. Otolaryngol Head Neck Surg Apr 2009; 140 (04) 487-492
• 95 Portas J, Queija DS, Arine L, Ferreira A, Dedivitis R, Lehn C et al. Voice and swallowing disorders: functional results and quality of life following supracricoid laryngectomy with cricohyoidoepiglottopexy. Ear Nose Throat J Oct 2009; 88 (10) E23-E30
• 96 Yüce I, CS Bayram A, Karasu F, Sati I, Güney E. The effect of arytenoid resection on functional results of cricohyoidopexy. Otolaryngol Head Neck Surg Aug 2009; 141 (02) 272-275
• 97 Mantsopoulos K, Psychogios G, Koch M, Zenk J, Waldfahrer F, Iro H. Comparison of different surgical approaches in T2 glottic cancer. Head Neck Mar 3 2011;
• 98 Jepsen M, Gurushanthaiah D, Roy N, Smith M, Gray S Davis R Voice, speech, and swallowing outcomes in laser-treated laryngeal cancer. Laryngoscope 2003; 113 (06) 923-928
• 99 Nemr N, de Carvalho M, Köhle J, Leite G, Rapoport A, Szeliga R. Functional study of the voice and swallowing following supracricoid laryngectomy. Braz J Otorhinolaryngol Mar-Apr 2007; 73 (02) 151-155
• 100 Olthoff A, Ewen A, Wolff H, Hermann R, Vorwerk H, Hille A et al. Organ function and quality of life after transoral laser microsurgery and adjuvant radiotherapy for locally advanced laryngeal cancer. Strahlenther Onkol May 2009; 185 (05) 303-309 Epub 2009 May 15
• 101 Kazi R, Prasad V, Venkitaraman R, Nutting C, Clarke P, Rhys-Evans P et al. Questionnaire analysis of the swallowing-related outcomes following total laryngectomy. Clin Otolaryngol. Dec 2006; 31 (06) 525-530
• 102 Xi S. Effectiveness of voice rehabilitation on vocalisation in postlaryngectomy patients: a systematic review. Int J Evid Based Healthc Dec 2010; 8 (04) 256-258
• 103 Hutcheson K, Lewin J, Sturgis E, Kapadia A, Risser J. Enlarged tracheoesophageal puncture after total laryngectomy: a systematic review and meta-analysis. Head Neck Jan 2011; 33 (01) 20-30 Review
• 104 Hutcheson K, Lewin J, Sturgis E, Risser J. Outcomes and adverse events of enlarged tracheoesophageal puncture after total laryngectomy. Laryngoscope Jul 2011; 121 (07) 1455-1461 [Epub 2011 Jun 6]
• 105 van la Parra R, Kon M, Schellekens P, Braunius W, Pameijer F. The prognostic value of abnormal findings on radiographic swallowing studies after total laryngectomy. Cancer Imaging Jun 11 2007; 7: 119-125
• 106 Dworkin J, Meleca R, Zacharek M, Stachler R, Pasha R, Abkarian G et al. Voice and deglutition functions after the supracricoid and total laryngectomy procedures for advanced stage laryngeal carcinoma. Otolaryngol Head Neck Surg Oct 2003; 129 (04) 311-320
• 107 Robertson S, Yeo J, Dunnet C, Young D, Mackenzie K. Voice, swallowing, and quality of life after total laryngectomy-Results of the west of Scotland laryngectomy audit. Head Neck Mar 17 2011; [Epub ahead of print]
• 108 Vilaseca I, Chen AY, Backscheider AG. Long-term quality of life after total laryngectomy. Head Neck 2006; 28 (04) 313-320
• 109 de Casso C, Slevin N, Homer J. The impact of radiotherapy on swallowing and speech in patients who undergo total laryngectomy. Otolaryngol Head Neck Surg Dec 2008; 139 (06) 792-797
• 110 Vilaseca I, Chen A, Backscheider A. Long-term quality of life after total laryngectomy. Head Neck Apr 2006; 28 (04) 313-320
• 111 Danker H, Wollbrück D, Singer S, Fuchs M, Brähler E, Meyer A. Social withdrawal after laryngectomy. Eur Arch Otorhinolaryngol Apr 2010; 267 (04) 593-600 [Epub 2009 Sep 16]
• 112 Fung K, Lyden T, Lee J, Urba S, Worden F, Eisbruch A. Voice and swallowing outcomes of an organ-preservation trial for advanced laryngeal cancer. Int J Radiat Oncol Biol Phys Dec 1 2005; 63 (05) 1395-1399 [Epub 2005 Aug 8]
• 113 Clark J, Gilbert R, Irish J, Brown D, Neligan P, Gullane P. Morbidity after flap reconstruction of hypopharyngeal defects. Laryngoscope Feb 2006; 116 (02) 173-181
• 114 Lewin J, Barringer D, May A, Gillenwater A, Arnold K, Roberts D et al. Functional outcomes after laryngopharyngectomy with anterolateral thigh flap reconstruction. Head Neck Feb 2006; 28 (02) 142-149
• 115 Moradi P, Glass G, Atherton D, Eccles S, Coffey M, Majithia A et al. Reconstruction of pharyngolaryngectomy defects using the jejunal free flap: a 10-year experience from a single reconstructive center. Plast Reconstr Surg Dec 2010; 126 (06) 1960-1966
• 116 Wu P, Kuo Y, Jeng S, Hsu C, Su C. Functional outcomes of patients with advanced pyriform sinus cancer treated with extended near-total laryngopharyngectomy and free fasciocutaneous flap reconstruction. Eur Arch Otorhinolaryngol Dec 2010; 267 (12) 1951-1956
• 117 Morrissey A, O’Connell D, Garg S, Seikaly H, Harris J. Radial forearm versus anterolateral thigh free flaps for laryngopharyngectomy defects: prospective, randomized trial. J Otolaryngol Head Neck Surg Aug 2010; 39 (04) 448-453
• 118 Nyquist G, Hier M, Dionisopoulos T, Black M. Stricture associated with primary tracheoesophageal puncture after pharyngolaryngectomy and free jejunal interposition. Head Neck Mar 2006; 28 (03) 205-209
• 119 Oniscu G, Walker W, Sanderson R. Functional results following pharyngolaryngooesophagectomy with free jejunal graft reconstruction. Eur J Cardiothorac Surg Apr 2001; 19 (04) 406-410
• 120 Scharpf J, Esclamado R.. Reconstruction with radial forearm flaps after ablative surgery for hypopharyngeal cancer. Head Neck Apr 2003; 25 (04) 261-266
• 121 Hanasono M, Lin D, Wax M, Rosenthal E. Closure of laryngectomy defects in the age of chemoradiation therapy. Head Neck Mar 17 2011;
• 122 Cmelak A, Li S, Goldwasser M, Murphy B, Cannon M, Pinto H et al. Phase II trial of chemoradiation for organ preservation in resectable stage III or IV squamous cell carcinomas of the larynx or oropharynx: results of Eastern Cooperative Oncology Group Study E2399. J Clin Oncol Sep 1 2007; 25 (25) 3971-3977
• 123 Forastiere A, Goepfert H, Maor M, TF P, Weber R, Morrison W et al. Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med Nov 27 2003; 349 (22) 2091-2098
• 124 Late Effects of Normal Tissues (LENT) Consensus Conference. Lent soma scales for all anatomic sites. International Journal of Radiation Oncol Biol Phys 1995; 31 (05) 1049-1091
• 125 Dworkin J, Hill S, Stachler R, Meleca R, Kewson D. Swallowing function outcomes following nonsurgical therapy for advanced-stage laryngeal carcinoma. Dysphagia Jan 2006; 21 (01) 66-74
• 126 Mouw K, Haraf D, Stenson K, Cohen E, Xi X, Witt M et al. Factors associated with long-term speech and swallowing outcomes after chemoradiotherapy for locoregionally advanced head and neck cancer. Arch Otolaryngol Head Neck Surg Dec 2010; 136 (12) 1226-1234
• 127 Boscolo-Rizzo P, Maronato F, Marchiori C, Gava A, Da Mosto M. Long-term quality of life after total laryngectomy and postoperative radiotherapy versus concurrent chemoradiotherapy for laryngeal preservation. Laryngoscope Feb 2008; 118 (02) 300-306
• 128 Guibert M, Lepage B, Woisard V, Rives M, Serrano E, Vergez S. Quality of life in patients treated for advanced hypopharyngeal or laryngeal cancer. Eur Ann Otorhinolaryngol Head Neck Dis May 23 2011; [Epub ahead of print]
• 129 Hanna E, Sherman A, Cash D, Adams D, Vural E, Fan C et al. Quality of life for patients following total laryngectomy vs chemoradiation for laryngeal preservation. Arch Otolaryngol Head Neck Surg Jul 2004; 130 (07) 875-879
• 130 Trivedi N, Swaminathan D, Thankappan K, Chatni S, Kuriakose M, Iyer S. Comparison of quality of life in advanced laryngeal cancer patients after concurrent chemoradiotherapy vs total laryngectomy. Otolaryngol Head Neck Surg Nov 2008; 139 (05) 702-707
• 131 Mares Azevedo E, Montoni N, Gonçalves Filho J, Kowalski L, Angelis E. Vocal Handicap and Quality of Life After Treatment of Advanced Squamous Carcinoma of the Larynx and/or Hypopharynx. J Voice Jul 1 2011; [Epub ahead of print]
• 132 Klozar J, Cada Z, Koslabova E. Complications of total laryngectomy in the era of chemoradiation. Eur Arch Otorhinolaryngol Apr 17 2011; [Epub ahead of print]
• 133 Cavalot A, Gervasio C, Nazionale G, Albera R, Bussi M, Staffieri A et al. Pharyngocutaneous fistula as a complication of total laryngectomy: review of the literature and analysis of case records. Otolaryngol Head Neck Surg Nov 2000; 123 (05) 587-592
• 134 Weber R, Berkey B, Forastiere A, Cooper J, Maor M, Goepfert H et al. Outcome of salvage total laryngectomy following organ preservation therapy: the Radiation Therapy Oncology Group trial 91-11. Arch Otolaryngol Head Neck Surg Jan 2003; 129 (01) 44-49
• 135 Sakai A, Okami K, Sugimoto R, Ebisumoto K, Yamamoto H, Furuya H et al. Multivariate analysis of wound complications after surgery for laryngeal and hypopharyngeal cancers. ORL J Otorhinolaryngol Relat Spec 2011; 73 (02) 100-104
• 136 Fung K, Teknos T, Vandenberg C, Lyden T, Bradford C, Hogikyan N et al. Prevention of wound complications following salvage laryngectomy using free vascularized tissue. Head Neck May 2007; 29 (05) 425-430
• 137 Watkins J, Williams G, Mascioli A, Wan J, Samant S. Shoulder function in patients undergoing selective neck dissection with or without radiation and chemotherapy. Head Neck May 2011; 33 (05) 615-619
• 138 Teymoortash A, Hoch S, Eivazi B, Werner J. Postoperative morbidity after different types of selective neck dissection. Laryngoscope May 2010; 120 (05) 924-929
• 139 Epstein J, Hong C, Logan R, Barasch A, Gordon S, Oberle-Edwards L et al. A systematic review of orofacial pain in patients receiving cancer therapy. Support Care Cancer Aug 2010; 18 (08) 1023-1031 [Epub 2010 Jun 11]
• 140 Pigni A, Brunelli C, Caraceni A. The role of hydromorphone in cancer pain treatment: a systematic review. Palliat Med Jul 2011; 25 (05) 471-477
• 141 Navez M. Otolaryngological cancer pain at the after-effects stage. Ann Otolaryngol Chir Cervicofac Oct 2007; 124 (Suppl. 01) S39-S44
• 142 van Wouwe M, de Bree R, Kuik D, de Goede C, Verdonck-de Leeuw I, Doornaert P et al. Shoulder morbidity after non-surgical treatment of the neck. Radiother Oncol Feb 2009; 90 (02) 196-201 Epub 2008 Dec 4
• 143 Raber-Durlacher J, Elad S, Barasch A. Oral mucositis. Oral Oncol Jun 2010; 46 (06) 452-456 [Epub 2010 Apr 18]
• 144 Rosenthal D, Trotti A. Strategies for managing radiation-induced mucositis in head and neck cancer. Semin Radiat Oncol Jan 2009; 19 (01) 29-34
• 145 Feller L, Essop R, Wood N, Khammissa R, Chikte U, Meyerov R et al. Chemotherapy- and radiotherapy-induced oral mucositis: pathobiology, epidemiology and management. SADJ Sep 2010; 65 (08) 372-374
• 146 Garg S, Yoo J, Winquist E. Nutritional support for head and neck cancer patients receiving radiotherapy: a systematic review. Support Care Cancer Jun 2010; 18 (06) 667-677
• 147 Paleri V, Patterson J. Use of gastrostomy in head and neck cancer: a systematic review to identify areas for future research. Clin Otolaryngol 2010; 35 (03) 177-189
• 148 Paleri V, Patterson J. Use of gastrostomy in head and neck cancer: a systematic review to identify areas for future research. Clin Otolaryngol Jun 2010; 35 (03) 177-189
• 149 Rosenthal D, Lewin J EA Prevention and treatment of dysphagia and aspiration after chemoradiation for head and neck cancer. J Clin Oncol Jun 10 2006; 24 (17) 2636-2643
• 150 Nguyen N, Frank C, Moltz C, Vos P, Smith H, Nguyen P et al. Analysis of factors influencing aspiration risk following chemoradiation for oropharyngeal cancer. Br J Radiol Aug 2009; 82 (980) 675-680
• 151 Rogers S, Thomson R, O’Toole P, Lowe D. Patients experience with long-term percutaneous endoscopic gastrostomy feeding following primary surgery for oral and oropharyngeal cancer. Oral Oncol May 2007; 43 (05) 499-507 [Epub 2006 Sep 25]
• 152 Kazi R, Prasad V, Venkitaraman R, Nutting C, Clarke P, Rhys-Evans P et al. Questionnaire analysis of swallowing-related outcomes following glossectomy. ORL J Otorhinolaryngol Relat Spec 2008; 70 (03) 151-155 [Epub 2008 Apr 8]
• 153 Brookes J, Seikaly H, Diamond C, Mechor B, Harris J. Prospective randomized trial comparing the effect of early suturing of tracheostomy sites on postoperative patient swallowing and rehabilitation. J Otolaryngol Apr 2006; 35 (02) 77-82
• 154 Ruo Redda M, Allis S. Radiotherapy-induced taste impairment. Cancer Treat Rev 2006; 32 (07) 541-547
• 155 Halyard M, Jatoi A, Sloan J, Bearden JR, Vora S, Atherton P et al. Does zinc sulfate prevent therapy-induced taste alterations in head and neck cancer patients? Results of phase III double-blind, placebo-controlled trial from the North Central Cancer Treatment Group (N01C4). Int J Radiat Oncol Biol Phys Apr 1 2007; 67 (05) 1318-1322
• 156 Singer S, Krauß O, Keszte J, Siegl G, Papsdorf K, Severi E et al. Predictors of emotional distress in patients with head and neck cancer. Head Neck Mar 11 2011;
• 157 Neilson K, Pollard A, Boonzaier A, Corry J, Castle D, Mead K et al. Psychological distress (depression and anxiety) in people with head and neck cancers. Med J Aust Sep 6 2010; 193 (5 Suppl) S48-S51
• 158 Hassanein K, Musgrove B, Bradbury E. Psychological outcome of patients following treatment of oral cancer and its relation with functional status and coping mechanisms. J Craniomaxillofac Surg Dec 2005; 33 (06) 404-409
• 159 Horney D, Smith H, McGurk M, Weinman J, Herold J, Altman K et al. Associations between quality of life, coping styles, optimism, and anxiety and depression in pretreatment patients with head and neck cancer. Head Neck Jan 2011; 33 (01) 65-71
• 160 Verdonck-de Leeuw I, Eerenstein S, Van der Linden M, Kuik D, de Bree R, Leemans C. Distress in spouses and patients after treatment for head and neck cancer. Laryngoscope Feb 2007; 117 (02) 238-241
• 161 Verdonck-de Leeuw I, van Bleek W, Leemans C, de Bree R. Employment and return to work in head and neck cancer survivors. Oral Oncol Jan 2010; 46 (01) 56-60 [Epub 2009 Dec 9]
• 162 Hamid O, El Fiky L, Medani M, Abdelhady A, Ali H. Laryngeal cancer in Egypt: Quality of life measurement with different treatment modalities. Head Neck Aug 2011; 33 (08) 1162-1169
• 163 Tschiesner U, Linseisen E, Baumann S, Siedek V, Stelter K, Berghaus A. Assessment of functioning in patients with head and neck cancer according to the International Classification of Functioning, Disability, and Health (ICF): a multicenter study. Laryngoscope 2009; 119 (05) 915-923
• 164 Abendstein H, Nordgren M, Boysen M, Jannert M, Silander E, Ahlner-Elmqvist M et al. Quality of life and head and neck cancer: a 5 year prospective study. Laryngoscope Dec 2005; 115 (12) 2183-2192
• 165 Duke R, Campbell B, Indresano A, Eaton D, Marbella A, Myers K et al. Dental status and quality of life in long-term head and neck cancer survivors. Laryngoscope Apr 2005; 115 (04) 678-683
• 166 Frowen J, Perry A. Swallowing outcomes after radiotherapy for head and neck cancer: a systematic review. Head Neck 2006; 28 (10) 932-944
• 167 Stucki G, Ewert T, Cieza A. Value and Application of the ICF in Rehabilitation Medicine. Disability and Rehabilitation 2002; 24: 932-938
• 168 Schuntermann M. Einführung in die ICF. eco med Medizin 2007. 2. Auflage
• 169 Roe J, Carding P, Dwivedi R, Kazi R, Rhys-Evans P, Harrington K et al. Swallowing outcomes following Intensity Modulated Radiation Therapy (IMRT) for head & neck cancer – a systematic review. Oral Oncol 2010; 46 (10) 727-733 [Epub 2010 Sep 17]
• 170 Brach M, Cieza A, Stucki G, Fussl M, Cole A, Ellerin B et al. ICF Core Sets for breast cancer. J Rehabil Med 2004; (44 Suppl) 121-127
• 171 Cieza A, Stucki A, Geyh S, Berteaunu M, Quittan M. ICF Core set for chronic ischemic heart disease. J Rehab Med Suppl 2004; 44: 94-99
• 172 Ruof J, Cieza A, Wolff B, Angst F, Ergeletzis D, Omar Z et al. ICF Core set for Diabetes Mellitus. J Rehabil. Med Suppl 2001; 44: 100-106
• 173 Stucki A, Stoll T, Cieza A, Weigl M. ICF Core Sets for obstructive pulmonary disease. J Rehabil med Suppl 2004; 44: 114-120
• 174 Tschiesner U, Rogers S, Dietz A, Yueh B, Cieza A. Development of ICF core sets for head and neck cancer. Head Neck 2010; 32 (02) 210-220
• 175 Tschiesner U, Becker S, Cieza A.. Health professional perspective on disability in head and neck cancer. Arch Otolaryngol Head Neck Surg 2010; 136 (06) 576-583
• 176 Tschiesner U, Linseisen E, Coenen M, Rogers S, Harreus U, Berghaus A et al. Evaluating sequelae after head and neck cancer from the patient perspective with the help of the International Classification of Functioning, Disability and Health. Eur Arch Otorhinolaryngol 2009; 266 (03) 425-436
• 177 Tschiesner UM, Rogers SN, Harreus U, Berghaus A, Cieza A. Comparison of outcome measures in head and neck cancer–literature review 2000-2006. Head Neck 2009; 31 (02) 251-259
• 178 Becker S, Kirchberger I, Cieza A, Berghaus A, Harreus U, Tschiesner U. Content validation of the Comprehensive ICF Core Set for Head and Neck Cancer (HNC): The perspective of psychologists. Psychooncology 2009; 19 (06) 594-605
• 179 Leib A, Cieza A, Tschiesner U. Perspective of physicians within a multidisciplinary team – Content validation of the Comprehensive ICF Core Set for Head and Neck Cancer. Head Neck May 8 2011; (in press)
• 180 Tschiesner U, Linseisen E, Becker S, Mast G, Rogers SN, Walvekar RR et al. Content validation of the international classification of functioning, disability and health core sets for head and neck cancer: a multicentre study. J otolaryngol head neck surg 2010; 39 (06) 674-687
• 181 Tschiesner U, Oberhauser C, Cieza A. Do the categories of the ICF-HNC discriminate among clinically relevant subgroups of patients?. Int J Rehabil Res 2011; 34 (02) 121-130
• 182 Rogers SN, Forgie S, Lowe D, Precious LH, S Tschiesner U. Development of the brief ICF core set for head and neck cancer as a patient self-completed questionnaire Int. J. Oral Maxillofac Surg Oct 2010; 39 (10) 975-982
• 183 Licitra L, Bossi P, Locati L. A multidisciplinary approach to squamous cell carcinomas of the head and neck: what is new?. Curr Opin Oncol 2006; 18 (03) 253-257
• 184 Westin T, Stalfors J. Tumour boards/multidisciplinary head and neck cancer meetings: are they of value to patients, treating staff or a political additional drain on healthcare resources?. Curr Opin Otolaryngol Head Neck Surg 2008; 16 (02) 103-107
• 185 Cieza A, Brockow T, Ewert T, Amman E, Kollerits B, Chatterji S et al. Linking health-status measurements to the International Classification of Functioning, Disability and Health. J Rehabil Med 2002; 34: 205-210
• 186 Cieza A, Geyh S, Chatterji S, Kostanjsek N, Üstün B, Stucki G. ICF linking rules: an update based on lessons learned. J Rehab Med 2005; 37: 212-218
• 187 Brockow T, Duddeck K, Geyh S, Schwarzkopf S, Weigl M et al. Identifying concepts contained in outcome measures of clinical trials on breast cancer using the ICF as a reference. J Rehabil Med Suppl 2004; 44: 43-48
• 188 Geyh S, Kurt T, Brockow T, Cieza A, Ewert T, Omar Z et al. Identifying the concepts contained in outcome measures of clinical trials on stroke using the International Classification of Functioning, Disability and Health as a reference. J Rehabil Med 2004; 44 Suppl: 56-62
• 189 Dwivedi R, Kazi R, Agrawal N, Nutting C, Clarke P, Kerawala C et al. Evaluation of speech outcomes following treatment of oral and oropharyngeal cancers. Cancer Treat Rev 2009; 35 (05) 417-424
• 190 Dey P, Arnold D, Wight R, MacKenzie K, Kelly C, Wilson J. Radiotherapy versus open surgery versus endolaryngeal surgery (with or without laser) for early laryngeal squamous cell cancer. Cochrane Database Syst Rev 2002; (2)) CD002027
• 191 Kanatas A, Mehanna H, Lowe D, Rogers S. A second national survey of health-related quality of life questionnaires in head and neck oncology. Ann R Coll Surg Engl 2009; 91 (05) 420-425
• 192 Funk GF, Karnell LH, Smith RB, Christensen AJ. Clinical significance of health status assessment measures in head and neck cancer: what do quality-of-life scores mean?. Arch Otolaryngol Head Neck Surg 2004; 130 (07) 825-829
• 193 Orlikoff R, Kraus D, Budnick A, Pfister D. Vocal function following successful chemoradiation treatment for advanced laryngeal cancer: preliminary results. Phonoscope 1999; 2: 67-77
• 194 Thomas L, Jones T, Tandon S, Katre C, Lowe D, Rogers S. An evaluation of the University of Washington Quality of Life swallowing domain following oropharyngeal cancer. Eur Arch Otorhinolaryngol Jul 2008; 265 (Suppl. 01) S29-S37 [Epub 2007 Oct 20]
• 195 Thomas L, Jones T, Tandon S, Carding P, Lowe D, Rogers S.. Speech and voice outcomes in oropharyngeal cancer and evaluation of the University of Washington Quality of Life speech domain. Clin Otolaryngol Feb 2009; 34 (01) 34-42