Synthesis and Pharmacological Investigation of Segetalin C as a Novel Antifungal and Cytotoxic Agent

Abstract

In present study, a natural phenylalanine-rich cycloheptapeptide segetalin C (compound VIII) was synthesized by coupling and cyclization of peptide units Boc-gly-L-leu-L-his-OH and L-Phe-L-ala-L-phe-L-pro-OMe and examined for different bioactivities. The structure of compound VIII was elucidated by IR, ¹H NMR, ¹³C NMR, mass spectral data and elemental analysis. It was demonstrated that the newly synthesized cyclopeptide has good activity against pathogenic fungi Candida albicans and dermatophytes, in addition to high cytotoxicity against Dalton’s lymphoma ascites (DLA) and Ehrlich’s ascites carcinoma (EAC) cell lines with CTC₅₀ values of 3.35 and 5.72 µmol/L.

Key words

Antimicrobials - Cytotoxic agents - Heptapeptide, cyclic - Segetalin C, anthelmintic activity, antimicrobial evaluation, cytotoxicity - Vaccaria segetalis

• Literature

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