Arzneimittelforschung 2008; 58(1): 29-34
DOI: 10.1055/s-0031-1296463
Antibiotics · Antimycotics · Antiviral Drugs · Chemotherapeutics · Cytostatics
Editio Cantor Verlag Aulendorf (Germany)

Synthesis and Pharmacological Investigation of Segetalin C as a Novel Antifungal and Cytotoxic Agent

Rajiv Dahiya
1   Pharmaceutical Chemistry Department, Rajiv Academy for Pharmacy, Mathura, Uttar Pradesh, India
,
Komalpreet Kaur
1   Pharmaceutical Chemistry Department, Rajiv Academy for Pharmacy, Mathura, Uttar Pradesh, India
› Author Affiliations
Further Information

Publication History

Publication Date:
15 December 2011 (online)

Abstract

In present study, a natural phenylalanine-rich cycloheptapeptide segetalin C (compound VIII) was synthesized by coupling and cyclization of peptide units Boc-gly-L-leu-L-his-OH and L-Phe-L-ala-L-phe-L-pro-OMe and examined for different bioactivities. The structure of compound VIII was elucidated by IR, 1H NMR, 13C NMR, mass spectral data and elemental analysis. It was demonstrated that the newly synthesized cyclopeptide has good activity against pathogenic fungi Candida albicans and dermatophytes, in addition to high cytotoxicity against Dalton’s lymphoma ascites (DLA) and Ehrlich’s ascites carcinoma (EAC) cell lines with CTC50 values of 3.35 and 5.72 µmol/L.

 
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