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Arzneimittelforschung 2009; 59(12): 666-671
DOI: 10.1055/s-0031-1296457
Antibiotics · Antimycotics · Antiparasitics · Antiviral Drugs · Chemotherapeutics · Cytostatics
Editio Cantor Verlag Aulendorf (Germany)

Novel Antitumor Acetamide, Pyrrole, Pyrrolopyrimidine, Thiocyanate, Hydrazone, Pyrazole, Isothiocyanate and Thiophene Derivatives Containing a Biologically Active Pyrazole Moiety

Saleh I. Alqasoumi
1   Medicinal, Aromatic and Poisonous Plants Research Center (MAPPRC), College of Pharmacy, King Saud University, Riyadh, (Saudi Arabia)
,
Moustafa M. Ghorab
1   Medicinal, Aromatic and Poisonous Plants Research Center (MAPPRC), College of Pharmacy, King Saud University, Riyadh, (Saudi Arabia)
,
Zeinab H. Ismail
2   Chemistry Department, Faculty of Science (Girls), Al-Azhar University, Cairo, (Egypt)
,
Soad M. Abdel-Gawad
2   Chemistry Department, Faculty of Science (Girls), Al-Azhar University, Cairo, (Egypt)
,
Mohamed S.A. El-Gaby
3   Chemistry Department, Faculty of Science, Al-Azhar University at Assiut, Assiut, (Egypt)
,
Hala M. Aly
2   Chemistry Department, Faculty of Science (Girls), Al-Azhar University, Cairo, (Egypt)
› Author Affiliations
Further Information

Publication History

Publication Date:
13 December 2011 (online)

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Abstract

4-Amino-N-(1-phenyl-1H-pyrazol-5-yl)-benzenesulfonamide (sulfaphenazole) 1 was selected as strategic starting material for the synthesis of some novel acetamide 2, pyrrole 4, pyrrolo[2,3-d]pyrimidine 5, thiocyanate 6, hydrazone 7a,b pyrazole 8, isothiocyanate 9 and thiophene 12 derivatives to evaluate the antitumor activity. Compound 4 was more effective than the reference drug, doxorubicin (CAS 23214-92-8) as positive control.

Key words

Acetamide, hydrazone, pyrazole derivatives, pyrrole, pyrrolopyrimidine, thiocyanate - Antitumor activity
 

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