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Arzneimittelforschung 2009; 59(12): 659-665
DOI: 10.1055/s-0031-1296456
Antibiotics · Antimycotics · Antiparasitics · Antiviral Drugs · Chemotherapeutics · Cytostatics
Editio Cantor Verlag Aulendorf (Germany)

Synthesis and Antimicrobial Activity of Some Novel Thiazolidine-2,4-dione Derivatives

Arzu Menteşe
1   Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Tandogan, Ankara, (Turkey)
,
Meltem Ceylan-Ünlüsoy
1   Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Tandogan, Ankara, (Turkey)
,
Oya Bozdağ-Dündar
1   Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Tandogan, Ankara, (Turkey)
,
Nurten Altanlar
2   Ankara University, Faculty of Pharmacy, Department of Microbiology, Tandoğan, Ankara, (Turkey)
,
Rahmiye Ertan
1   Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Tandogan, Ankara, (Turkey)
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Publikationsverlauf

Publikationsdatum:
13. Dezember 2011 (online)

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Abstract

In this study, a series of phenylefhylsul-fanyl-1,3-thiazolo-thiazolidine-2,4-dione derivatives (VII a –f, VIII a–f) and 5-methyl-[1,2,4] triazolyl-sulfanyl-1,3-fhia-zolo-thiazolidine-2,4-dione derivatives (IXa–f, Xa–f) were synthesized and evaluated for their antibacterial and antifungal activities against S. aureus (ATCC 25923), methicillin resistant S. aureus (MRSA ATCC 43300), B. subtilis (ATCC 6633), E. coli (ATCC 23556) and C. albicans (ATCC10145). All the compounds were found active against used bacteria.

Key words

Antimicrobial activity - Thiazoles - Thiazolidine-2,4-diones - Triazoles
 

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