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Arzneimittelforschung 2010; 60(1): 48-55
DOI: 10.1055/s-0031-1296248
Antibiotics · Antimycotics · Antiparasitics · Antiviral Drugs · Chemotherapeutics · Cytostatics
Editio Cantor Verlag Aulendorf (Germany)

Synthesis of some new pyrazole and pyrimidine derivatives carrying a sulfonamide moiety of expected antitumor activity and study of the synergistic effect of γirradiation

Mostafa M Ghorab
1   Department of Drug Radiation Research, National Center for Radiation Research and Technology, Atomic Energy Authority, Nasr City, Cairo, Egypt
,
Fatma A Ragab
2   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt
,
Helmy I Heiba
1   Department of Drug Radiation Research, National Center for Radiation Research and Technology, Atomic Energy Authority, Nasr City, Cairo, Egypt
,
Hanan A Youssef
2   Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt
,
Marwa Gala
1   Department of Drug Radiation Research, National Center for Radiation Research and Technology, Atomic Energy Authority, Nasr City, Cairo, Egypt
› Author Affiliations
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Publication History

Publication Date:
02 December 2011 (online)

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Abstract

Several novel pyrazole (11–18) and pyri-midine (19–23) derivatives were synthesized starting from different sulfonamides and different active methylenes The synthesized compounds were characterized by elemental analysis, IR, 1H-NMR and mass spectral data. The obtained compounds were screened as antitumor agents against human tumor cell line. Some of the tested compounds were equipotent while the others were more potent than doxorubicin (CAS 25316-40-9). The synergistic effect with g-radiation was also studied.

Key word

γ-Irradiation - Pyrazole derivative - Pyrimidine derivative - Sulfonamides, antitumor activity
 

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