Synthesis of some new pyrazole and pyrimidine derivatives carrying a sulfonamide moiety of expected antitumor activity and study of the synergistic effect of γirradiation

Mostafa M Ghorab; Fatma A Ragab; Helmy I Heiba; Hanan A Youssef; Marwa Gala

doi:10.1055/s-0031-1296248

Arzneimittelforschung, Table of Contents

Arzneimittelforschung 2010; 60(1): 48-55
DOI: 10.1055/s-0031-1296248

Antibiotics · Antimycotics · Antiparasitics · Antiviral Drugs · Chemotherapeutics · Cytostatics

Editio Cantor Verlag Aulendorf (Germany)

Synthesis of some new pyrazole and pyrimidine derivatives carrying a sulfonamide moiety of expected antitumor activity and study of the synergistic effect of γirradiation

Mostafa M Ghorab

¹Department of Drug Radiation Research, National Center for Radiation Research and Technology, Atomic Energy Authority, Nasr City, Cairo, Egypt

,

Fatma A Ragab

²Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt

,

Helmy I Heiba

¹Department of Drug Radiation Research, National Center for Radiation Research and Technology, Atomic Energy Authority, Nasr City, Cairo, Egypt

,

Hanan A Youssef

²Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt

,

Marwa Gala

¹Department of Drug Radiation Research, National Center for Radiation Research and Technology, Atomic Energy Authority, Nasr City, Cairo, Egypt

› Author Affiliations

Abstract

Several novel pyrazole (11–18) and pyri-midine (19–23) derivatives were synthesized starting from different sulfonamides and different active methylenes The synthesized compounds were characterized by elemental analysis, IR, ¹H-NMR and mass spectral data. The obtained compounds were screened as antitumor agents against human tumor cell line. Some of the tested compounds were equipotent while the others were more potent than doxorubicin (CAS 25316-40-9). The synergistic effect with g-radiation was also studied.

Key word

γ-Irradiation - Pyrazole derivative - Pyrimidine derivative - Sulfonamides, antitumor activity

Full Text

References

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