Design and synthesis of some novel hydrazide, 1,2-dihydropyridine, chromene derivatives carrying biologically active sulfone moieties with potential anticancer activity

Mahmoud S Bashandy; Mansour S. Al-Said; Saleh I. Al-Qasoumi; Mostafa M. Ghorab

doi:10.1055/s-0031-1296238

Arzneimittelforschung, Inhaltsverzeichnis

Arzneimittelforschung 2011; 61(9): 521-526
DOI: 10.1055/s-0031-1296238

Antibiotics · Antimycotics · Antiparasitics · Antiviral Drugs · Chemotherapeutics · Cytostatics

Editio Cantor Verlag Aulendorf (Germany)

Design and synthesis of some novel hydrazide, 1,2-dihydropyridine, chromene derivatives carrying biologically active sulfone moieties with potential anticancer activity

Mahmoud S Bashandy

¹Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt

,

Mansour S. Al-Said

²Medicinal, Aromatic and Poisonous Plants Research Center (MAPPRC), College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

,

Saleh I. Al-Qasoumi

³Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

,

Mostafa M. Ghorab

²Medicinal, Aromatic and Poisonous Plants Research Center (MAPPRC), College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

⁴Department of Drug Radiation Research, National Center for Radiation Research and Technology, Nasr City, Cairo, Egypt

› Institutsangaben

Abstract

This paper describes the synthesis of some novel sulfones having biologically active hydrazides (4-9, 22, 23, 26 and 27), hydrazonoyl cyanide (24), 1,2-dihydro-pyridines (16-21), chromene (28) and benzochromene (29) moieties starting with 1-[4-(piperidin-1-ylsulfonyl)phenyl]-ethanone 1. The structures of the the newly synthesized compounds were confirmed by elemental analysis, IR, ¹H NMR and ¹³C NMR. All the newly synthesized compounds were evaluated for their in vitro anticancer activity against breast cancer cell line (MCF7).

Key words

Anticancer activity - Breast cancer cell line - Chromene derivatives - 1,2-Dihydropyridine - Hydrazide derivatives - Sulfone derivatives

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References
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