19-Oxygenated ent-Kaurane Diterpenoids from Isodon pharicus

Abstract

Eight new 19-oxygenated ent-kaurane diterpenoids (1–8) were isolated from the aerial parts of Isodon pharicus. Their structures were determined by means of extensive spectroscopic techniques including interpretation of 1D and 2D NMR spectra. Selected compounds were evaluated for their cytotoxicity against NB4, A549, PC-3, MCF-7, and SH-SY5Y cell lines.

Key words

Lamiaceae - Isodon pharicus - diterpenoid - cytotoxicity

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