Planta Med 2011; 77(18): 2053-2056
DOI: 10.1055/s-0031-1280086
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Cytotoxic and Antibacterial Flavonoids from Dragon's Blood of Dracaena cambodiana

Ying Luo1 [*] , Hui Wang1 , 2 [*] , You-Xing Zhao1 , 2 , Yan-Bo Zeng1 , 2 , Hai-Yan Shen1 , Hao-Fu Dai1 , 2 , Wen-Li Mei1 , 2
  • 1Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, Hainan, P. R. China
  • 2Haikou Key Laboratory for Research and Development of Tropical Natural Products, Haikou, Hainan, P. R. China
Further Information

Publication History

received May 8, 2011 revised June 20, 2011

accepted June 24, 2011

Publication Date:
28 July 2011 (online)

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Abstract

Chemical studies on the constituents from the dragon's blood of Dracaena cambodiana led to the discovery of three new flavonoid derivatives (13) and six known compounds (49). The structures of the three new compounds were elucidated by NMR and MS spectroscopic analyses. All compounds were evaluated for their growth inhibitory activity against human cell lines K-562, SMMC-7721, and SGC-7901, as well as antibacterial activities against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA). As a result, compounds 1, 2, 5, 7, and 9 showed cytotoxicity against K-562, SMMC-7721, and SGC-7901 cell lines. All these compounds were observed to exhibit antibacterial activities against S. aureus, and compounds 14, 6, 8, and 9 were observed to exhibit antibacterial activity against MRSA.

Supporting Information

References

1 These authors contributed equally to this work.

Prof. Dr. Hao-Fu Dai

Institute of Tropical Bioscience and Biotechnology
Chinese Academy of Tropical Agricultural Sciences

4 Xueyuan Road, Longhua District

Haikou 571101 Hainan

P. R. China

Phone: +86 898 66 96 18 69

Fax: +86 898 66 98 18 69

Email: hfdai2001@yahoo.com.cn

Prof. Dr. Men-Li Mei

Institute of Tropical Bioscience and Biotechnology
Chinese Academy of Tropical Agricultural Sciences

4 Xueyuan Road, Longhua District

Haikou 571101 Hainan

P. R. China

Phone: +86 898 66 96 75 29

Fax: +86 898 66 98 75 29

Email: meiwenli@yahoo.com.cn