Leukoencephalopathy with Vanishing White Matter: Serial MRI of the Brain and Spinal Cord including Diffusion Tensor Imaging

A. Meoded; A. Poretti; S. Yoshida; T.A.G.M. Huisman

doi:10.1055/s-0031-1279784

Neuropediatrics, Table of Contents

Neuropediatrics 2011; 42(02): 82-85
DOI: 10.1055/s-0031-1279784

Short Communication

Georg Thieme Verlag Stuttgart · New York

Leukoencephalopathy with Vanishing White Matter: Serial MRI of the Brain and Spinal Cord including Diffusion Tensor Imaging

A. Meoded

¹Division of Pediatric Radiology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA

,

A. Poretti

¹Division of Pediatric Radiology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA

²Department of Pediatric Neurology, University Children′s Hospital, Zurich, Switzerland

,

S. Yoshida

³Laboratory of Brain Anatomical MRI, Russell H. Morgan, Department of Radiology and Radiological Science, The Johns Hopkins School of Medicine, Baltimore, MH, USA

,

T.A.G.M. Huisman

¹Division of Pediatric Radiology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA

› Author Affiliations

Abstract

Vanishing white matter disease (VWM) is one of the most frequent inherited childhood white matter disorders. We present the brain and spinal cord disease progression on serial conventional magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) in a 4-year-old boy. Consecutive MRI examinations demonstrated a progression of the signal abnormalities in the cerebral white matter. Globally, apparent diffusion coefficient (ADC) values as well as axial and radial diffusivity increased over time, while fractional anisotropy (FA) values decreased. Involvement of the cervical posterior spinal tracts and mild global spinal cord atrophy was found. In conclusion, serial MRI and DTI studies may help to better understand the selective injury of the myelin and axons in VWM disease. These data may help in monitoring disease progression. Our data also show that complete neuroimaging work-up in VWM should also include the spinal cord.

Key words

vanishing white matter disease - white matter disorders - neuroimaging - diffusion tensor imaging - MR spectroscopy - spinal cord

Full Text

References

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