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Planta Med 2011; 77(14): 1631-1638
DOI: 10.1055/s-0030-1270992
Natural Product Chemistry
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Oleanane-Type Triterpene Saponins and Cassaine-Type Diterpenoids from Erythrophleum fordii

Dan Du1 , Lei Fang1 , Jing Qu1 , Shishan Yu1 , Shuanggang Ma1 , Haining Lv1 , Jing Liu1 , Yuanyan Liu1 , Jiaming Wang1 , Xiaojing Wang1
  • 1Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education , and Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China
Further Information

Publication History

received Sept. 13, 2010 revised March 10, 2011

accepted March 20, 2011

Publication Date:
11 April 2011 (online)

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Abstract

Phytochemical investigation of the EtOH extract of the leaves of Erythrophleum fordii led to the isolation of two oleanane-type triterpene saponins (1–2) and five cassaine-type diterpenoids (4–8) along with one known methyl 3β-hydroxy-erythrosuamate (3). Their structures were established by extensive NMR, as well as ESI‐MS analyses and acid hydrolysis. Biological evaluation of compounds 3–8 against five human cancer cell lines revealed that compounds 5–7 exhibited potent cytotoxic activity with IC50 values ranging from 1.51 to 8.68 µM.

Key words

Erythrophleum fordii Oliver - Leguminosae - oleanane‐type triterpene saponin - cassaine‐type diterpenoid - cytotoxic activity

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Prof. Dr. Shishan Yu

Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine
Ministry of Education and Institute of Materia Medica
Chinese Academy of Medical Sciences and Peking Union Medical College

No. 1 Xian Nong Tan Street

Beijing 100050

People's Republic of China

Phone: +86 10 63 16 53 24

Fax: +86 10 63 01 77 57

Email: yushishan@imm.ac.cn

    www.thieme-connect.de/ejournals/toc/plantamedica