A New Quinoline Epoxide from the Australian Plant Drummondita calida

Abstract

A drug discovery program aimed at identifying new antimalarial leads from a prefractionated natural product library has resulted in the purification of a new quinoline alkaloid, (2′R)-2′,3′-epoxy-N-methylatanine (1), along with eight known natural products, skimmianin (2), γ-fagarine (3), maculosidine (4), evolitrine (5), dictamnine (6), pteleine (7), N-methylatanine (8), and werneria chromene (9). Compound 1 displayed 74 % inhibition at 80 µM against a chloroquine-resistant Plasmodium falciparum strain (Dd2).

Key words

Drummondita calida - Rutaceae - antimalaria - quinoline alkaloids - epoxide

References

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