Planta Med 2011; 77(14): 1648-1651
DOI: 10.1055/s-0030-1270962
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

New Cytotoxic Cucurbitacins from Wilbrandia ebracteata Cogn.

Karen L. Lang1 , Tatiana da Rosa Guimarães2 , Vanessa Rocha Machado2 , Lara A. Zimmermann2 , Izabella T. Silva2 , Marina R. Teixeira2 , Fernando J. Durán3 , Jorge A. Palermo3 , Cláudia M. O. Simões2 , Miguel S. B. Caro1 , Eloir P. Schenkel2
  • 1Department of Chemistry, Federal University of Santa Catarina, Florianópolis, SC, Brazil
  • 2Department of Pharmaceutical Sciences, Federal University of Santa Catarina, Florianópolis, SC, Brazil
  • 3UMYMFOR – Department of Organic Chemistry, University of Buenos Aires, Buenos Aires, Argentina
Weitere Informationen

Publikationsverlauf

received November 18, 2010 revised January 26, 2011

accepted March 13, 2011

Publikationsdatum:
06. April 2011 (online)

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Abstract

Chemical investigation of the roots of Wilbrandia ebracteata Cogn. (Cucurbitaceae) led to the isolation of two new (12) and four known (36) cucurbitacins. Their structures were elucidated by NMR and MS and compared with related compounds. The in vitro cytotoxicity of isolated compounds was evaluated against RD, KB, HCT-8, and A549 cell lines showing strong activity.

References

Prof. Dr. Eloir Paulo Schenkel

Center of Health Sciences
Department of Pharmaceutical Science
Federal University of Santa Catarina (UFSC)
Campus Universitário Trindade Florianópolis

R. Delfino Conti, s/n

CEP 88040-900 Santa Catarina

Brazil

Telefon: +55 48 37 21 50 76

Fax: +55 48 32 44 09 36

eMail: eloirschenkel@gmail.com