Männermedizin: Mikronährstoffe und Leistungsfähigkeit im Alter

Udo Böhm

doi:10.1055/s-0030-1257702

Erfahrungsheilkunde, Table of Contents

Erfahrungsheilkunde 2011; 60(6): 351-356
DOI: 10.1055/s-0030-1257702

Aus der Praxis für die Praxis

Männermedizin: Mikronährstoffe und Leistungsfähigkeit im Alter

Authors

Udo Böhm

Abstract

Zusammenfassung

Es gibt viele Möglichkeiten für Männer, ihre Gesundheit und Leistungsfähigkeit zu verbessern. Besonders effektiv sind Lebensstilmaßnahmen und eine vollwertige pflanzlich orientierte Ernährung. In der Ernährung sind es wiederum die Mikronährstoffe, deren Nutzen aufgrund der umfassenden Kenntnisse über ihre Beeinflussung des gesamten Stoffwechsels und aufgrund zahlreicher Studien nachgewiesen ist.

Der Artikel stellt die wichtigsten Mikronährstoffe und ihren Einfluss auf Gesundheit und Leistungsfähigkeit vor und gibt Tipps für die Umsetzung der Mikronährstoffmedizin in der Praxis.

Abstract

There are many opportunities for men, to improve their health and fitness. Measures concerning lifestyle and a wholesome, vegetarian-oriented diet are especially effective. As far as diet is concerned, the benefit of micronutrients is proven due to the extensive knowledge about their influence on the whole metabolism and due to several studies.

In the article, the most important micronutrients and their influence on health and fitness are presented and advice is given for implementing micronutrient medicine in practice.

Schlüsselwörter

Männermedizin - Mikronährstoffe - Leistungsfähigkeit im Alter

Keywords

Medicine for men - micronutrients - fitness in age

Full Text

References

Literatur
1 Chen J et al. Effect of oral administration of high-dose nitric oxide donor L-arginine in men with organic erectile dysfunction: results of a double-blind, randomized, placebo-controlled study. BJU Int 1999; 83: 269-273
2 Besset A et al. Increase in sleep related Growth Hormone after chronic arginine aspartate administration in man. Acta Endocrinol (Copenh). 1982. 99. 18-23
3 Kuan KJ et al. Oral vitamin E and folic acid supplementation during sildenafil therapy for erectile dysfunction improves salvage in non-responders. AUA; 2003. Conference-Report
4 Yusuf S et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet 2004; 364: 937–952 and Rosengren A et al.; Association of psychosocial risk factors with risk of acute myocardial infarction in 11 119 cases and 13 648 controls from 52 countries (the INTERHEART study): case-control study. Lancet 2004; 364: 953-962
5 Labinskyy N et al. Vascular dysfunction in aging: potential effects of resveratrol, an anti-inflammatory phytoestrogen. Curr Med Chem 2006; 13: 989-996
6 Cesari M et al. Antioxidants and physical performance in elderly persons: the Invecchiare in Chianti (InCHIANTI) study. Am J Clin Nutr 2004; 79: 289-294
7 Richards BJ et al. Higher serum vitamin D concentrations are associated with longer leucocyte telomere length in women. Am J Clin Nutr 2007; 86: 1420-1425
8 Mecocci P et al. Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain. Ann Neurol 1993; 34: 609-616
9 Luft R. The development of mitochondrial medicine. Proc Natl Acad Sci 1994; 91: 8731-8738
10 Mendoza-Nunez MV et al. Aging related oxidative stress in healthy humans. Tohoku J Exp Med 2007; 213: 261-268
11 Aydemir B et al. The influence of oxidaitve damage on viscosity of seminal fluid in infertiel men. J Androl 2008; 29: 41-46
12 Milne CJ et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 2007; 450: 712-716
13 Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nature Reviews Drug Discovery 2006; 5: 493-506
14 Luna C et al. Resveratrol prevents the expression of glaucoma markers induced by chronic oxidative stress in trabecular meshwork cells. Food and Chemical Toxicology 2009; 47: 198-204
15 Pearson KJ, Baur AJ et al Cell Metab. 2008; 8: 157-168
16 Bernard M et al. The effect of vitamin B12 deficiency on older veterans an its relationship to health. J Am Geriatr Soc 1998; 46: 1199-1206
17 Megclani SM. Nutrition Reviews. 1993. 51. 106
18 Chandra RK. Effect of vitamin and trace-element supplementation on immune responses and infection in elderly subjects. Lancet 1992; 340: 1124-1127
19 Meydani M. Antioxidants and cognitive function. Nut Rev 2001; 59: 75-82
20 Gruber FO. Selen und Alter. VitaMinSpur 1989; 4: 74
21 Zhang MS et al. Intakes of vitamins E and C, carotenoids, vitamin supplements, and PD risk. Neurology 2002; 59: 1161-1169
22 Dhesi KJ et al. Vitamin D supplementation improves neuromuscular function in older people who fall. Age and Ageing 2004; 33: 589-595
23 Mc Geer LP, and McGeer EG. Inflammation and the degenerative diseases of aging. Ann NY Acad Sci 2004; 1035: 104-116
24 Licastro F et al. Innate immunity and inflammation in ageing: a key for understanding age-related diseases. Immunity & Ageing 2005; 2: 8
25 Lavrovsky Y et al. Role of redox-regulated transcription factors in inflammation, aging and age-related diseases. Experimental Gerontology 2000; 35: 521-532
26 Leeuwenburgh C et al. Mitochondria and aging. J Aging Res et al. 2011; 2011: 782946
27 Trifunovic A, Larsson NG. Mitochondrial dysfunction as a cause of ageing. J Intern Med 2008; 263: 167-178
28 Zoltan U et al. Mitochondria and aging in the vascular system. J Mol Med (Berl) 2010; 88 (10): 1021-1027
29 Parker et al. Cancer Statistics 1997. CA Cancer J Clin 1997; 47: 5-27
30 Tavani A et al. Intake of selected micronutrients and the risk of surgically treated benign prostatic hyperplasia: a case-control study from Italy. Eur Urol 2006; 50: 549-554
31 Hong JS et al. Comparative study of concentration of isoflavones and lignans in plasma and prostatic tissues of normal control and benign prostatic hyperplasia. Yonsei Med J 2002; 43: 236-241
32 Brössner C et al. Phytoestrogen tissue levels in benign prostatic hyperplasia and prostate cancer and their association with prostatic diseases. Urology 2004; 64: 707-711
33 Cavallini G et al. Carnitine versus androgen administration in the treatment of sexual dysfunction, depressed mood, and fatigue associated with male aging. Urology 2004; 63: 641-646
34 Besset A et al. Increase in sleep related GH and Prl secretion after chronic arginine aspartate administration in man. Acta Endocrinol (Copenh). 1982. 99. 18-23
35 Blum A et al. Endocrine and lipid effects of oral L-arginine treatment in healthy postmenopausal women. J Lab Clin Med 2000; 135: 231-237
36 Chen J et al. Effect of oral administration of high-dose nitric oxide donor L-arginine in men with organic erectile dysfunction. BJU Int 1999; 83: 269-273
37 Said TM, Agarwal A, Sharma KR et al. Human sperm superoxide anion generation and correlation with semen quality in patients with male infertility. Fertil Steril 2004; 82: 871-877
38 Pasqualotto FF et al. Oxidative stress in normospermic men undergoing infertility evaluation. J Androl 2001; 22: 316-322
39 Lenzi A et al. Placebo-controlled, double-blind, cross-over trial of glutathione therapy in male infertility. Hum Reprod 1993; 8: 1657-1656
40 Costa M et al. L-carnitine in idiopathic asthenozoospermia: a multicenter study. Italian Study Group on Carnitine and Male Infertility; Andrologia 1994; 26: 155-159
41 Wong YW et al. Effects of folic acid and zinc sulfate on male factor subfertility: a double-blind, randomized, placebo-controlled trial. Fertil Steril 2002; 77: 491-498
42 Scott R et al. The effect of oral selenium supplementation on human sperm motility. Br J Urol 1998; 82: 76-80
43 Lenzi A et al. A placebo-controlled double-blind randomized trial of the use of combined L-Carnitine and L-Acetylcarnitine treatment in men with asthenozoospermia. Fertil Steril 2004; 81: 1578-1584
44 Nüesch R et al. Plasma and urine canitine concentrations in well-trained athlets at rest and after exercise. Influence of L-carnitine intake. Drugs Expl Clin Res 1999; XXV: 167-171
45 Marconi C et al. Effects of L-carnitine loading on the aerobic and anaerobic performance of endurance athletes. Eur J Appl Physiol Occup Physiol 1985; 54: 131-135
46 Cha SY et al. Effects of carnitine coingested caffeine on carnitine metabolism and endurance capacity in athletes. J Nutr Sci Vitaminol 2001; 47: 378-384
47 Ylioski T et al. The effect of coenzyme Q10 on the exercise performance of cross-country skiers. Mol Aspects Med. 1997; 18 (Suppl): S283-S290
48 Palazzetti S et al. Antioxidant supplementation preserves antioxidant response in physical training and low antioxidant intake. Br J Nutr 2004; 91: 91-100
49 Peters ME et al. Vitamin C supplementation reduces the incidence of postrace symptoms of upper-respiratory-tract infection in ultramarathon runners. Am J Clin Nutr 1993; 57: 170-174
50 Tauler P et al. Diet supplementation with vitamin E, vitamin C and Beta-carotene cocktail enhances basal neutrophil antioxidant enzymes in athletes. Eur J Physiol 2002; 443: 791-797
51 Schröder H et al. Nutrition antioxidant status and oxidative stress in professional basketball players: effects of a three compound antioxidative supplement. Int J Sports Me 2000; 21: 146-150
52 Grievink L et al. Double-blind intervention trial on modulation of ozone effects on pulmonary function by antioxidant supplements. Am J Epidemiol 1999; 149: 306-314
53 Schoenthaler et al. The effect of vitamin-mineral supplementation on the intelligence of American schoolchildren. J Altern Complement Med 2000; 6: 19-29
54 Durga J et al. Effect of 3-year folic acid supplementation cognitive function in older adults in the FACIT trial: a randomised, double blind, controlled trial. Lancet 2007; 369: 208-216
55 Penland GJ et al. Zinc affects cognition and psychosocial function of middle-school children. Journal of Federation of American Societies for Experimental Biology 2005; 19 A973
56 Grodstein F et al. A randomized trial of beta carotene supplementation and cognitive function in men. Arch Int Med 2007; 167: 2184-2190
57 Gariballa S et al. A randomized, double-blind, placebo-controlled trial of nutritional supplementation during acute illness. Am J Med 2006; 119: 693-699
58 Chandra RK. Effect of vitamin and trace element supplementation on immune responses and infection in elderly subjects. Lancet 1992; 340: 1124-1127
59 Langkamp-Henken B et al. Nutritional formula enhanced immune function and reduced days of symptoms of upper respiratory tract infection in seniors. Journal of the American Geriatrics Society 2004; 52: 3
60 Clark CL et al. Decreased incidence of prostate cancer with selenium supplementation. Br J Urol 1998; 730-734
61 Duffield-Lillico JA et al. Selenium supplementation, baselone plasma selenium status and incidence of prostate cancer: an analysis of the complete treatment period of the Nutritional Prevention of Cancer Trial. BJU International 2003; 91: 608-612
62 Yoshizawa K et al. Study of prediagnostic selenium level in toenails and the risk of advanced prostate cancer. J Natl Cancer Inst 1998; 90: 1219-1224
63 Heinonen PO et al. Prostate cancer and supplementation with alpha-tocopherol and beta-carotene: incidence and mortality in a controlled trial. J Natl Cancer Inst 1998; 90: 440-446
64 Chan MJ et al Supplemental vitamin E intake and prostate cancer risk in a large cohort of men in the United States. Cancer Epidemiology Biomarkers & Prevention 1999; 8: 893-899
65 Etminan M et al. The role of tomato products and lycopene in the prevention of prostate cancer: a meta-analysis of observational studies. Cancer Epidemiology Biomarkers & Prevention 2004; 13: 340-345
66 Giovannucci E et al. A prospective study of tomato products, lycopene, and prostate cancer risk. Journal of the National Cancer Institute 2002; 94: 391-398
67 Gann HP et al. Lower prostate risk in men with elevated plasma lycopene levels: results of a prospective analysis. Cancer Research 1999; 59: 1225-1236
68 Adlerkreutz H et al. Plasma concentrations of phyto-oestrogens in Japanese men. Lancet 1993; 342: 1209-1210
69 Davis NJ et al. Soy isoflavone supplementation in healthy men prevents NF-kappaB activation by TNF-alpha in blood lymphocytes. Free Radical Biology & Medicine 2001; 30: 1293-1302
70 Augustsson K et al. A prospective study of intake of fish and marine fatty acids and prostate cancer. Cancer Epidemiology Biomarkers & Prevention 2003; 12: 64-67
71 Terry P et al. Fatty fish consumption and risk of prostate cancer. The Lancet 2001; 357: 1764
72 Steinmetz AK et al. Vegetables, fruit, and cancer prevention: a review. J Am Diet Assoc 1996; 96: 1027-1039
73 Hercberg S et al. SU.VI.MAX. Arch Intern Med 2004; 164: 2335-2342
74 Clark CL et al. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group. JAMA 1996; 276: 1957-1963
75 Giovannucci E et al. Prospective study of predictors of vitamin D status and cancer incidence and mortality in men. JNCI Journal of the National Cancer Institute 2006; 98 (7): 451-459
76 Stryker SW et al. Diet, plasma levels of beta-carotene and alpha-tocopherol, and risk of malignant melanoma. Am J Epidemiol 1990; 131: 597-611
77 Beratungs-Standards der DGE. 1999
78 Semba DR et al. Low serum micronutrient concentrations predict frailty among older woman living in the communitiy. J Gerontology Series A: Biological Sciences and Medical Sciences 2006; 61: 594-599
79 Agudo A et al. Fruit and vegetable intakes, dietary antioxidant nutrients, and total mortality in Spanish adults: findings from the Spanish cohort of the European Prospective Investigation into cancer and Nutrition (EPIC Spain). Am J Clin Nutr 2007; 6: 1634-1642
80 Block G et al. Usage patterns, health and nutritional status of long-term multiple dietary supplement users: a cross sectional study. Nutr J 2007; 6: 30
81 Brink CT et al. Age-related transcriptional changes in gene expression in different organs of mice support the metabolic stability theory of aging. Biogerontology 2008;
82 Scibona M et al. L-arginine and male infertility. Minerva Urol Nephrol 1994; 46: 251-253
83 Langkamp-Henken B et al. Nutritional formula enhanced immune function and reduced days of symptoms of upper respiratory tract infection in seniors. Journal of the American Geriatrics Society 2004; 52: 3
84 Barringer AT et al. Effect of a multivitamin and mineral supplement on infection and quality of life. Ann Intern Med 2003; 138: 365-371
85 Holmquist C et al. Multivitamin supplements are inversely associated with risk of myocardial infarction in men and women – Stockholm Heart Epidemiology Program. J Nutr 2003; 133: 2650-2654
86 Estruch R et al. Predimed-Studie (Prevención con Dieta Mediterránea): effects of a mediterranean-style diet on cardiovascular risk factors – a randomized trial. Annals of Internal Medicine 2006; 145: 1-11
87 Farvid SM et al. The impact of vitamins and/or mineral supplementation on blood pressure in type 2 diabetes. Journal of the American College of Nutrition 2004; 23: 272-279
88 Keogh A et al. Coenzyme Q10 therapy in NYHA class II and III. Systolic Heart Failure, Heart, Lung and Circulation 2003; 12: 135
89 Löster H et al Cardiovasc Drugs Ther. 1999; 13: 537-546
90 Deutsche Gesellschaft für Mann und Gesundheit, Stiftung Männergesundheit. Erster deutscher Männerbericht. Tagesspiegel 28.10.2010
91 Löffler G. Basiswissen Biochemie mit Pathobiochemie. 7 Aufl. Berlin: Springer; 2008
92 Seshadri S et al. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med Volume 2002; 346: 476-483
93 Engelhart JM et al. Dietary intake of antioxidants and risk of Alzheimer disease. JAMA 2002; 287: 3223-3229
94 Sano M et al. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. N Engl J Med 1997; 336: 1216-1222
95 Warsama JJama et al. Dietary antioxidants and cognitive function in a population-based sample of older persons: The Rotterdam Study. Am J Epidemiol 1996; 144: 275-280
96 Demir T et al. Hyperhomocysteinemia a novel risk factor for erectile dysfunction. Metabolism 2006; 55: 1564-1568
97 Naurath DH et al. Effects of vitamin B12, folate, and vitamin B6 supplements in elderly people with normal serum vitamin concentrations. Lancet 1995; 346: 85-89
98 Soinio M et al. Serum zinc level and coronary heart disease events in patients with type 2 diabetes. Diabetes Care 2007; 30: 523-528
99 Singh M et al. Zinc for the common cold. Cochrane Database of Systematic Reviews; 2011.
100 Haase H, Rink L. The immune system and the impact of zinc during aging. Immunity & Ageing 2009; 6: 9
101 Shankar AH, Prasad AS. Zinc and immune function: the biological basis of altered resistance to infection. Am J Clin Nutr 1998; 68 (Suppl): S447–S463
102 Brewer GJ. Subclinical zinc deficiency in Alzheimer’s Disease and Parkinson’s Disease. Am J Alzheimer’s Dis Other Demen 2010; 25: 572-575
103 Forsleff L et al. Evidence of functional zinc deficiency in Parkinson's disease. J Altern Complement Med 1999; 5: 57-64
104 Cope CE et al. Role of zinc in the development and treatment of mood disorders. Curr Opin Clin Nutr Metab Care 2010; 13: 685-689
105 Desser L et al. Oral therapy with proteolytic enzymes decreases excessive TGF-beta levels in human blood. Cancer Chemother Pharmacol 2001; 47 (Suppl): S10–S15
106 Gujral SM et al. Efficacy of hydrolytic enzymes in preventing radiation therapy-induced side effects in patients with head and neck cancers. Cancer Chemother Pharmacol 2001; 47: 24-29
107 Cox JA et al. Oral administration of the probiotic Lactobacillus fermentum VRI-003 and mucosal immunity in endurance athletes. Br J Sports Med 2010; 44: 222-226
108 Winkler P et al. Effect of dietary supplement containing probiotic bacteria plus vitamins and minerals on common cold infections and cellular immune parameters. Int J Clin Pharmacol Ther 2005; 43: 318-320
109 Pattison JD et al. Vitamin C and the risk of developing inflammatory polyarthritis: prospective nested case-control study. Ann Rheum Dis 2004; 63: 843-847
110 Sköldstam L et al. An experimental study of a mediterranean diet intervention for patients with rheumatoid arthritis. Ann Rheum Dis 2003; 62: 208-214
111 Ilich ZJ et al. Bone and nutrition in elderly women: protein, energy, and calcium as main determinants of bone mineral density. Eur J Clin Nutr 2003; 57 (4): 554-565
112 Dai Q et al. Fruit and vegetable juices and Alzheimer's disease: the Kame Project. Am J Med 2006; 119: 751-759
113 Scarmeas N et al. Mediterranean diet, Alzheimer’s disease, and vascular mediation. Arch Neurol 2006; 63
114 Scarmeas N et al. Mediteranean diet and risk for Alzheimer’s disease. Ann Neurol 2006; 59: 912-921
115 Benton D et al. Vitamin supplementation for 1 year improves mood. Neuropsychobiology 1995; 32: 98-105
116 Coppen A et al. Treatment of depression: time to consider folic acid and vitamin B12. J Psychopharmacol 2005; 19: 59-65