Background and study aim: Colonoscopy is regarded as the gold standard for diagnosis of colonic lesions. However,
adenoma miss rates in tandem colonoscopy studies vary from 2 % to 26 %. We aimed to
investigate the rates of advanced neoplasia in patients with a prior normal colonoscopy
in an outpatient endoscopy unit.
Methods: Review of reports for colonoscopies performed in our Endoscopy Unit from 2000 to
2005. Undetected lesions were defined as advanced adenoma or colorectal cancer (CRC)
not reported in a colonoscopy performed in the previous 2 or 3 years, respectively.
Patients with hereditary nonpolyposis CRC (HNPCC) and familial adenomatous polyposis
(FAP) were excluded.
Results: Between 2002 and 2005, 795 patients were diagnosed with at least one advanced adenoma
and 386 with CRC. Among these, 107/795 patients (13.5 %) had advanced adenoma that
had been undetected in a previous colonoscopy (39 % [53/135 lesions] in the right
colon); 92/107 (86 %) had an undetected advanced adenoma ≥ 10 mm. Previously undetected
CRCs were found in 27/386 patients (6.7 %), located in the left colon in 21/27 (78 %);
in 7 the area had not been reached in the previous colonoscopy. Risk factors for undetected
advanced adenoma were advanced age, male gender, the presence of another advanced
adenoma at first colonoscopy, and history of advanced neoplasia.
Conclusions: Failure to detect advanced neoplasia is common in a community-based endoscopy facility.
Previously undetected advanced lesions are more frequently found in the left colon
and rectum. Risk factors for non-detection of advanced adenoma are similar to those
for advanced neoplasia recurrence. Lowering non-detection rates is crucial for correct
follow-up recommendations. Patients should be aware of rates of detection of advanced
neoplasia after previous normal colonoscopic findings.
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A-163
A. FerrándezMD
Hospital Clinico Lozano Blesa – Digestive Diseases
Avenida San Juan Bosco 15
Zaragoza 50009
Spain
Fax: +34-976-556400
Email: angel.ferrandez@telefonica.net
