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DOI: 10.1055/s-0030-1255785
© Georg Thieme Verlag KG Stuttgart · New York
Obstructive jaundice as a complication of a peptic duodenal ulcer mimicking pancreatic cancer
L. Hidalgo
Digestive System Services
Virgen de la Salud Hospital
Avda Barber 30
45004 Toledo
Spain
Email: loha1983@hotmail.com
Publication History
Publication Date:
26 November 2010 (online)
A 56-year-old man was admitted to our gastroenterology department for upper gastrointestinal bleeding. The patient was a heavy smoker and drank an average of 50 g of ethanol per day. On urgent upper endoscopy, an active bleeding ulcer was observed in the upper wall of the first duodenal flexure. In spite of therapeutic sclerosis with epinephrine 1 : 10 000 (4 mL) and etoxiesclerol 2 % (4 mL) the ulcer bled again. After a second unsuccessful attempt at therapeutic endoscopy with injection of epinephrine 1 : 10 000 (6 mL) and etoxiesclerol 2 % (4 mL) the patient was operated and the bleeding point sutured. After 2 months, the patient was readmitted for painless obstructive jaundice. An abdominal computed tomography (CT) scan showed dilated intra- and extrahepatic bile ducts (up to the intrapancreatic portion) and an increase in the size of the pancreatic head with an ill-defined hypodense area measuring 21 × 13 mm ([Fig. 1]).
During endoscopic ultrasonography (EUS), a duodenal bulb ulcer with inflammation and mild stenosis of the duodenal flexure was observed. The EUS also revealed a lesion, 20 × 15 mm, with spiculated margins in the head of the pancreas and contiguous with the thickened duodenal wall ([Fig. 2]).
Endoscopic biopsies and the cytologic examination of the material obtained by EUS-guided fine-needle aspiration were negative for malignant cells. Percutaneous cholangiography performed shortly afterward showed abrupt obstruction of the distal bile duct. Surgery was finally required to treat the biliary obstruction and a cephalic duodenopancreatectomy was performed. Histological study of the surgical specimen showed a duodenal ulcer with scarring retraction involving the pancreatic head and distal bile duct, but with no malignant infiltration ([Fig. 3]).
The postoperative course was favorable, and 3 months after the operation the patient was asymptomatic and generally well.
Obstructive jaundice secondary to a local pancreatic lesion has been related to malignant pancreatic tumors or to pseudotumors of inflammatory etiology, such as chronic pancreatitis [1]. Bile obstruction as a complication of the treatment of a peptic ulcer is rare. Recently, this complication has been shown to be the result of a peri-ulcerous inflammatory component [2] or the result of hemostatic treatment using sclerotic substances [3].
Competing interests: None
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#References
- 1 Tony E, Yusuf M D, Manoop S, Bhután M D. Differentiating pancreatic cancer from pseudotumorous chronic pancreatitis. Curr Gastroenterol Reports. 2002; 4 135-139
- 2 Chiu-Yung H, Tseng-Shing C, Full-Young C, Shou-Dong L. Bening nontraumatic inflammatory stricture of mid portion of common bile duct mimicking malignant tumor: Report of two cases. World J Gastroenterol. 2004; 10 2153-2155
- 3 Luman W, Hudson N, Choudari C P. et al . Distal biliary stricture as a complication of sclerosant injection for bleeding duodenal ulcer. Gut. 1994; 35 1665-1667
L. Hidalgo
Digestive System Services
Virgen de la Salud Hospital
Avda Barber 30
45004 Toledo
Spain
Email: loha1983@hotmail.com
References
- 1 Tony E, Yusuf M D, Manoop S, Bhután M D. Differentiating pancreatic cancer from pseudotumorous chronic pancreatitis. Curr Gastroenterol Reports. 2002; 4 135-139
- 2 Chiu-Yung H, Tseng-Shing C, Full-Young C, Shou-Dong L. Bening nontraumatic inflammatory stricture of mid portion of common bile duct mimicking malignant tumor: Report of two cases. World J Gastroenterol. 2004; 10 2153-2155
- 3 Luman W, Hudson N, Choudari C P. et al . Distal biliary stricture as a complication of sclerosant injection for bleeding duodenal ulcer. Gut. 1994; 35 1665-1667
L. Hidalgo
Digestive System Services
Virgen de la Salud Hospital
Avda Barber 30
45004 Toledo
Spain
Email: loha1983@hotmail.com