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Exp Clin Endocrinol Diabetes 2010; 118(9): 571-576
DOI: 10.1055/s-0030-1255051
Review

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Mechanisms of Diabetic Nephropathy – Old Buddies and Newcomers Part 1

P. P. Nawroth1 , B. Isermann1
  • 1Department of Medicine I and Clinical Chemistry, University of Heidelberg, INF, Heidelberg, Germany
Further Information

Publication History

received 07.01.2010 first decision 10.03.2010

accepted 11.05.2010

Publication Date:
23 July 2010 (online)

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Abstract

Diabetic nephropathy is the most frequent cause of terminal kidney failure in industrialized countries. In addition, the manifestation of diabetic nephropathy is associated with a poor prognosis for affected patients. Current therapies are based on established pathophysiological models. However, despite reflecting significant progress in our understanding of diabetic nephropathy, the translational efforts fell short their expectations. The current review summarizes recent studies which provided new insights into established mechanisms (part 1) and studies identifying new candidate mechanisms (part 2) underlying diabetic nephropathy.

Key words

diabetes - nephropathy - disease mechanism

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Correspondence

Dr. B. Isermann

Universität Heidelberg

Innere Medizin I

INF 410

69120 Heidelberg

Germany

Phone: +49/06221/563 8608

Fax: +49/06221/564 233

Email: berend.isermann@med.uni-heidelberg.de

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