Planta Med 2011; 77(8): 845-848
DOI: 10.1055/s-0030-1250633
Biological and Pharmacological Activity
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Steroidal Saponins from the Rhizomes of Dioscorea bulbifera and Their Cytotoxic Activity

Hai Liu1 , 2 , Gui-Xin Chou1 , 2 , Jun-Ming Wang1 , Li-Li Ji1 , 2 , Zheng-Tao Wang1 , 2
  • 1The MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China
  • 2Shanghai R & D Centre for Standardization of Chinese Medicines, Shanghai, P. R. China
Further Information

Publication History

received July 4, 2010 revised November 21, 2010

accepted November 24, 2010

Publication Date:
16 December 2010 (online)

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Abstract

Two new steroidal saponins, diosbulbisides D (1) and E (2), along with five known saponins (37) were isolated from the rhizomes of Dioscorea bulbifera L. Their structures were elucidated on the basis of spectral data. Compounds 6 and 7, two 3-O-trisaccharides of diosgenin spirostanes, showed moderate cytotoxic activity against human hepatocellular carcinoma cells, with IC50 values of 3.89 µM and 7.47 µM on SMMC7721, and 10.87 µM and 19.10 µM on Bel-7402 cell lines, respectively.

References

Prof. Dr. Zheng-Tao Wang

The MOE Key Laboratory for Standardization of Chinese Medicines
Institute of Traditional Chinese Medicine
Shanghai University of Traditional Chinese Medicine

1200 Cailun Road

201210 Shanghai

P. R. China

Phone: +86 21 51 32 25 07

Fax: +86 21 51 32 25 19

Email: wangzht@hotmail.com