Lignan and Neolignan Glycosides from the Roots of Glehnia littoralis

Abstract

A new lignan glycoside [glehlinoside G (1)] and three new neolignan glycosides [glehlinosides H (2), I (3) and J (4)] were isolated from the roots of Glehnia littoralis. Their structures were elucidated on the basis of spectroscopic data. The above glehlinosides (1–4), together with the other lignan and neolignan glycosides (5–12) from this plant, were evaluated for their prolyl oligopeptidase inhibitory activities, and a caffeoyled lignan glycoside (glehlinoside F, 8) exhibited a noticeable activity (IC₅₀ = 14.5 µM).

Key words

Umbelliferae - Glehnia littoralis - lignan glycosides - neolignan glycosides - glehlinosides - prolyl oligopeptidase inhibitory activity

References

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