ACE and ACTN3 Genes and Muscle Phenotypes in Nonagenarians

N. Bustamante-Ara; C. Santiago; Z. Verde; T. Yvert; F. Gómez-Gallego; G. Rodríguez-Romo; P. González-Gil; J. A. Serra-Rexach; J. R. Ruiz; A. Lucia

doi:10.1055/s-0030-1247529

International Journal of Sports Medicine, Table of Contents

Int J Sports Med 2010; 31(4): 221-224
DOI: 10.1055/s-0030-1247529

Rapid Communication

ACE and ACTN3 Genes and Muscle Phenotypes in Nonagenarians

N. Bustamante-Ara¹ , C. Santiago¹ , Z. Verde¹ , T. Yvert¹ , F. Gómez-Gallego¹ , G. Rodríguez-Romo² , P. González-Gil³ , J. A. Serra-Rexach⁴ , J. R. Ruiz⁵ , A. Lucia¹

¹Universidad Europea de Madrid, Biomedicine, Madrid, Spain
²Universidad Politécnica, INEF, Madrid, Spain
³Residencia Los Nogales-Pacífico, Medical Department, Madrid, Spain
⁴Hospital Gregorio Marañón, Gerontology, Madrid, Spain
⁵Karolinska Institutet, Dpt. Biosciences and Nutrition, Unit for Preventive Nutrition, Huddinge, Sweden

Abstract

We studied the association of ACE and ACTN3 polymorphisms with skeletal muscle phenotypes (i. e. upper and lower body muscular strength and functional tests) in Spanish nonagenarian subjects [n=41, 33 women, 8 men, age: 90–97 years]. Mean values of the study phenotypes were not significantly different (all P>0.05) between ACE and ACTN3 genotypes. The analyses of the combined effects between genotypes (ACE DD & ACTN3 RR/RX vs. ACE II/ID & ACTN3 XX) did not yield any significant difference. Our data suggest that, in the elderly, the influence of genetic factors on muscle phenotype traits is not reducible to a few single polymorphisms, including ACE and ACTN3 variants.

Key words

nonagenarians - muscular strength - ACE genotype - ACTN3 genotype

Full Text

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Correspondence

Prof. Alejandro Lucia

Universidad Europea De Madrid Physiology

Villaviciosa de Odón

28670 Madrid

Spain

Phone: +34/916647800

Fax: +34/916168265

Email: alejandro.lucia@uem.es