Zusammenfassung
Die Bekämpfung von Viren ist immer noch ein Problem für
die konventionelle Medizin, wie aktuell die H1N1-Influenza zeigt. Mit
Mikronährstoffen und Granatapfel-Polyphenolen kann einer Infektion
vorgebeugt werden. Kommt es doch zur Infektion, ist mit einem milderen
Krankheitsverlauf zu rechnen.
Abstract
The struggle against viruses still is a problem for conventional
medicine, as can be presently seen in the case of H1N1 influenza. With
micronutrients and pomegranate polyphenols it is possible to take precautions
against the infection. If an infection is present, a milder course of the
disease can be expected.
Schlüsselwörter
Influenza - Granatapfel - Mikronährstoffe
Keywords
Influenza - pomegranate - micronutrients
Literatur
- 01
Adams J S, Hewison M.
Unexpected actions of vitamin D: new perspectives on the
regulation of innate and adaptive immunity.
Nat Clin Pract Endocrinol Metab.
2008;
4
80-90
- 02
Afaq F, Malik A, Syed D, Maes D, Matsui M S, Mukhtar H.
Pomegranate fruit extract modulates UV-B-mediated
phosphorylation of mitogen-activated protein kinases and activation of nuclear
factor kappaB in normal human epidermal keratinocytes paragraph sign.
Photochemistry and Photobiology.
2005;
81
38-45
- 03
Afaq F, Saleem M, Krueger C G, Reed J D, Mukhtar H.
Anthocyanin- and hydrolyzable tannin-rich pomegranate fruit
extract modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis
in CD-1 mice.
International Journal of Cancer.
2005;
113
423-433
- 04
Ahmed S, Wang N, Hafeez B B, Cheruvu V K, Haqqi T M.
Punica granatum L. extract inhibits IL-1beta-induced
expression of matrix metalloproteinases by inhibiting the activation of MAP
kinases and NF-kappaB in human chondrocytes in vitro.
Journal of Nutrition.
2005;
135
2096-2102
- 05
Akaike T, Noguchi Y, Ijiri S. et al .
Pathogenesis of influenza virus-induced pneumonia:
involvement of both nitric oxide and oxygen radicals.
Proc Natl Acad Sci U S A.
1996;
93.
6
2448-2453
- 06
Ajaikumar K B, Asheef M, Babu B H, Padikkala J.
The inhibition of gastric mucosal injury by Punica granatum
L. (pomegranate) methanolic extract.
Journal of Ethnopharmacology.
2005;
96
171-176
- 07
Aloia J, Li-Ng M.
Re: epidemic influenza and vitamin D.
Epidemiol Infect.
2007;
135.
7
1095-1096
- 08
Arthur J R, McKenzie R C, Beckett G J.
Selenium in the immune system.
J Nutr.
2003;
135
(S 1)
1457S-1459S
- 09
Aviram M, Dornfeld L, Rosenblat M. et al .
Pomegranate juice consumption reduces oxidative stress,
atherogenic modifications to LDL, and platelet aggregation: studies in humans
and in atherosclerotic apolipoprotein E-deficient mice.
American Journal of Clinical Nutrition.
2000;
71
1062-1076
- 10
Aviram M, Rosenblat M, Gaitini D. et al .
Pomegranate juice consumption for 3 years by patients with
carotid artery stenosis reduces common carotid intima-media thickness, blood
pressure and LDL oxidation.
Clinical Nutrition.
2004;
23
423-433
- 11
Azadzoi K M, Schulman R N, Aviram M, Siroky M B.
Oxidative stress in arteriogenic erectile dysfunction:
prophylactic role of antioxidants.
Journal of Urology.
2005;
174
386-393
- 12
Beck M A.
Selenium and vitamin E status: impact on viral
pathogenicity.
J Nutr.
2007;
137
1338-1340
- 13
Beck M A, Levander O A, Handy J.
Selenium deficiency and viral infection.
Exp Biol Med (Maywood).
2007;
232
412-419
- 14
Bellinger F P, Raman A V, Reeves M A, Berry M J.
Regulation and function of selenoproteins in human
disease.
Biochem J.
2009;
422
11-22
- 15
Brown K H, Peerson J M, Baker S K, Hess S Y.
Preventive zinc supplementation among infants, preschoolers,
and older prepubertal children.
Food Nutr Bull.
2009;
30
(S 1)
S12-40
- 16
Cannell J J, Vieth R, Umhau J C. et al .
Epidemic influenza and vitamin D.
Epidemiol Infect.
2006;
134
(6)
1129-1140
- 17
Cannell J J, Zasloff M, Garland C F, Scragg R, Giovannucci E.
On the epidemiology of influenza.
Virol J.
2008;
5
29
- 18
de Jong M D, Simmons C P, Thanh T T. et al .
Fatal outcome of human influenza A (H5N1) is associated with
high viral load and hypercytokinemia.
Nat Med.
2006;
12
(10)
1203-1207
- 19
Droebner K, Ehrhardt C, Poetter A, Ludwig S, Planz O.
CYSTUS052, a polyphenol-rich plant extract, exerts
anti-influenza virus activity in mice.
Antiviral Res.
2007;
76
(1)
1-10
- 20
Ehrhardt C, Hrincius E R, Korte V. et al .
A polyphenol rich plant extract, CYSTUS052, exerts anti
influenza virus activity in cell culture without toxic side effects or the
tendency to induce viral resistance.
Antiviral Res.
2007;
76
(1)
38-47
- 21
Haase H, Rink L.
The immune system and the impact of zinc during aging.
Immun Ageing.
2009;
12
(6)
9
- 22
Haidari M, Ali M, Ward Casscells 3rd S, Madjid M.
Pomegranate (Punica granatum) purified polyphenol extract
inhibits influenza virus and has a synergistic effect with oseltamivir.
Phytomedicine.
2009;
DOI: 10.1016/j.phymed.2009.06.002
- 23
Hartman R E. et al .
Pomegranate juice decreases amyloid load and improves
behavior in a mouse model of Alzheimer’s disease.
Neurobiol Dis.
2006;
24
(3)
506-515
- 24
Helfrich Y R, Kang S, Elalieh H Z. et al .
Injury enhances TLR2 function and antimicrobial peptide
expression through a vitamin D dependent mechanism.
J Clin Invest.
2007;
117
803-811
- 25
Ho E, Quan N, Tsai Y H, Lai W, Bray T M.
Dietary zinc supplementation inhibits NF-kappaB activation
and protects against chemically induced diabetes in CD1 mice.
Exp Biol Med.
2001;
226
(2)
103-111
- 26
Huang T H. et al .
Pomegranate flower extract diminishes cardiac fibrosis in
Zucker diabetic fatty rats: modulation of cardiac endothelin-1 and nuclear
factor-kappaB pathways.
Journal of Cardiovascular Pharmacology.
2005;
46
856-862
- 27
Hulisz D.
Efficacy of zinc against common cold viruses: an
overview.
J Am Pharm Assoc.
2003;
44
(5)
594-603
- 28
Ignarro L J, Byrns R E, Sumi D, de Nigris F, Napoli C.
Pomegranate juice protects nitric oxide against oxidative
destruction and enhances the biological actions of nitric oxide.
Nitric Oxide.
2006;
15
(2)
93-102
- 29
Jaspers I, Zhang W, Brighton L E, Carson J L, Styblo M, Beck M A.
Selenium deficiency alters epithelial cell morphology and
responses to influenza.
Free Radic Biol Med.
2007;
42
1826-1837
- 30
Jeeninga R E, de Jong M D, Berkhout B.
The new influenza A (H1N1) pandemic.
J Formos Med Assoc.
2009;
108
(7)
523-525
- 31
Kahmann L, Uciechowski P, Warmuth S. et al .
Zinc supplementation in the elderly reduces spontaneous
inflammatory cytokine release and restores T cell functions.
Rejuvenation Res.
2008;
11
(1)
227-237
- 32
Kaur G, Jabbar Z, Athar M, Alam M S.
Punica granatum (pomegranate) flower extract possesses potent
antioxidant activity and abrogates Fe-NTA induced hepatotoxicity in mice.
Food and Chemical Toxicology.
2006;
44
7
984-993
- 33
Khan N, Afaq F, Kweon M H, Kim K, Mukhtar H.
Oral consumption of pomegranate fruit extract inhibits growth
and progression of primary lung tumors in mice.
Cancer Res.
2007;
67
(7)
3475-3482
- 34
Khan N, Hadi N, Afaq F, Syed D N, Kweon M H, Mukhtar H.
Pomegranate fruit extract inhibits prosurvival pathways in
human A549 lung carcinoma cells and tumor growth in athymic nude mice.
Carcinogenesis.
2007;
28
(1)
163-173
- 35
Loren D J, Seeram N P, Schulman R N, Holtzman D M.
Maternal dietary supplementation with pomegranate juice is
neuroprotective in an animal model of neonatal hypoxic-ischemic brain
injury.
Pediatric Research.
2005;
57
858-864
- 36
Ludwig S, Planz O.
Influenza viruses and the NF-kappaB signaling pathway –
towards a novel concept of antiviral therapy.
Biol Chem.
2008;
389
(10)
1307-1312
- 37
Ludwig S.
Neue Wege in der Grippe-Therapie.
Biospektrum.
2009;
15
(3)
244-247
- 38
Mazur I, Wurzer W J, Ehrhardt C. et al .
Acetylsalicylic acid (ASA) blocks influenza virus propagation
via its NF-kappaB-inhibiting activity.
Cell Microbiol.
2007;
9
1683-1694
- 39
Mocchegiani E, Malavolta M, Muti E. et al .
Zinc, metallothioneins and longevity: interrelationships with
niacin and selenium.
Curr Pharm Des.
2008;
14
2719-2732
- 40
Nelson H K, Shi Q, Van Dael P. et al .
Host nutritional selenium status as a driving force for
influenza virus mutations.
FASEB J.
2001;
15
(10)
1846-1848
- 41
Neurath A R, Strick N, Li Y Y, Debnath A K.
Punica granatum (Pomegranate) juice provides an HIV-1 entry
inhibitor and candidate topical microbicide.
BMC Infect Dis.
2004;
4
41
- 42
Neurath A R, Strick N, Li Y Y, Debnath A K.
Punica granatum (pomegranate) juice provides an HIV-1 entry
inhibitor and candidate topical microbicide.
Ann NY Acad Sci.
2005;
1056
311-237
- 43
Nimmerjahn F, Dudziak D, Dirmeier U. et al .
Active NF-kappaB signalling is a prerequisite for influenza
virus infection.
J Gen Virol.
2004;
85
2347-2356
- 44
Pantuck A J. et al .
Phase II Study of Pomegranate Juice for Men with Rising
Prostate-Specific Antigen following Surgery or Radiation for Prostate
Cancer.
Clin Cancer Res.
2006;
12
(13)
4018-4026
- 45
Prasad A S, Fitzgerald J T, Bao B, Beck F W, Chandrasekar P H.
Duration of symptoms and plasma cytokine levels in patients
with the common cold treated with zinc acetate. A randomized, double-blind,
placebo-controlled trial.
Ann Intern Med.
2000;
133
(4)
302-303
- 46
Raloff J.
The antibiotic vitamin.
Science News.
2006;
170
312-317
- 47
Rasheed Z, Akhtar N, Anbazhagan A N, Ramamurthy S, Shukla M, Haqqi T M.
Polyphenol-rich pomegranate fruit extract (POMx) suppresses
PMACI-induced expression of pro-inflammatory cytokines by inhibiting the
activation of MAP Kinases and NF-kappaB in human KU812 cells.
J Inflamm (Lond).
2009;
6
1
- 48
Ravaglia G, Forti P, Maioli F. et al .
Effect of micronutrient status on natural killer cell immune
function in healthy free-living subjects aged >/= 90 y.
Am J Clin Nutr.
2000;
71
(2)
590-598
- 49
Reddy M K, Gupta S K, Jacob M R, Khan S I, Ferreira D May.
Antioxidant, antimalarial and antimicrobial activities of
tannin-rich fractions, ellagitannins and phenolic acids from punica granatum
L.
Planta.
2007;
73
(5)
461-467
- 50
Rimmelzwaan G F, Baars M M, de Lijster P, Fouchier R A, Osterhaus A D.
Inhibition of influenza virus replication by nitric
oxide.
Journal of Virology.
1999;
73
(10)
8880-8883
- 51
Rosenblat M, Hayek T, Aviram M.
Antioxidative effects of pomegranate juice (PJ) consumption
by diabetic patients on serum and on macrophages.
Atherosclerosis.
2006;
187
(2)
363-371
- 52
Schubert S Y, Lansky E P, Neeman I.
Antioxidant and eicosanoid enzyme inhibition properties of
pomegranate seed oil and fermented juice flavonoids.
J Ethnopharmacol.
1999;
66
(1)
11-17
- 53
Schubert S Y, Neeman I, Resnick N.
A novel mechanism for the inhibition of NF-kappaB activation
in vascular endothelial cells by natural antioxidants.
The Federation of American Societies for Experimental
Biology Journal.
2002;
16
1931-1933
- 54
Shukla M, Gupta K, Rasheed Z, Khan K A, Haqqi T M.
Consumption of hydrolyzable tannins-rich pomegranate extract
suppresses inflammation and joint damage in rheumatoid arthritis.
Nutrition.
2008;
24
(7–8)
733-743
- 55
Shukla M, Gupta K, Rasheed Z, Khan K A, Haqqi T M.
Bioavailable constituents / metabolites of
pomegranate (Punica granatum L) preferentially inhibit COX2 activity ex vivo
and IL-1beta-induced PGE2 production in human chondrocytes in vitro.
J Inflamm (Lond).
2008;
5
(1)
9
- 56
Sumner M D. et al .
Effects of pomegranate juice consumption on myocardial
perfusion in patients with coronary heart disease.
Am J Cardiol.
2005;
96
(6)
810-814
- 57
Syed D N, Malik A, Hadi N, Sarfaraz S, Afaq F, Mukhtar H.
Photochemopreventive effect of pomegranate fruit extract on
UVA-mediated activation of cellular pathways in normal human epidermal
keratinocytes.
Photochem Photobiol.
2006;
82
(2)
398-405
- 58
Toklu H Z, Dumlu M U, Sehirli O. et al .
Pomegranate peel extract prevents liver fibrosis in
biliary-obstructed rats.
J Pharm Pharmacol.
2007;
59
(9)
1287-1295
- 59
Türk G, Sönmez M, Aydin M. et al .
Effects of pomegranate juice consumption on sperm quality,
spermatogenic cell density, antioxidant activity and testosterone level in male
rats.
Clin Nutr.
2008;
27
(2)
289-296
- 60
Tuerk M J, Fazel N.
Zinc deficiency.
Curr Opin Gastroenterol.
2009;
25
(2)
136-143
- 61
Vasto S, Mocchegiani E, Malavolta M. et al .
Zinc and inflammatory/immune response in aging.
Ann N Y Acad Sci.
2007;
1100
111-122
- 62
Woodland D V.
Does New Swine Flu Virus Kill by Causing a „Cytokine
Storm”?.
Viral Immunology.
2009;
2009;
- 63
Wurzer W J, Ehrhardt C, Pleschka S. et al .
NF-kappaB-dependent induction of tumor necrosisfactor-related
apoptosis-inducing ligand (TRAIL) and Fas/FasL is crucial for efficient
influenza virus propagation.
J Biol Chem.
2004;
279
30931-30937
- 64
Zakay-Rones Z, Thom E, Wollan T, Wadstein J.
Randomized study of the efficacy and safety of oral
elderberry extract in the treatment of influenza A and B virus infections.
J Int Med Res.
2004;
32
(2)
132-140
- 65
Zakay-Rones Z, Varsano N, Zlotnik M. et al .
Inhibition of several strains of influenza virus in vitro and
reduction of symptoms by an elderberry extract (Sambucus nigra L.) during an
outbreak of influenza B Panama.
J Altern Complement Med.
1995;
1
(4)
361-369
- 66
Zasloff M.
Inducing endogenous antimicrobial peptides to battle
infections.
Proc Natl Acad Sci USA.
2006;
103
8913-8914
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