Zusammenfassung
Die Adipositas ist eine globale Epidemie, von der in Deutschland ca. 20 % der Einwohner
betroffen sind. Zukünftig werden Anästhesisten daher häufiger adipöse und extrem adipöse
Patienten betreuen müssen. Voraussetzung dafür ist die räumliche und apparative Ausrichtung
der Klinik auf die Behandlung dieser Patientengruppe. Wichtige Begleiterkrankungen
wie Diabetes mellitus, Hypertonus, koronare Herzkrankheit und das Schlaf–Apnoe–Syndrom
erhöhen das Risiko adipöser Patienten signifikant. Notwendig sind eine sorgfältige,
präoperative Abklärung relevanter Begleiterkrankungen, eine auf die Besonderheiten
der Pathophysiologie abgestimmte Narkoseeinleitung und –beatmung und die Kenntnis
der pharmakokinetischen Kennzahlen von Anästhetika, um eine optimale Behandlung adipöser
Patienten gewährleisten zu können.
Abstract
Obesity is a global epidemic, and approximately 20 % of the German population are
obese. Therefore anaesthesiologists will be increasingly involved in the care of obese
and morbidly obese patients in the near future. As a prerequisite, the hospital must
focus on this patient population with respect to facilities and the availability of
tailored medical equipment and supplies. Comorbidities such as diabetes, hypertension,
coronary heart disease and sleep apnea considerably increase the risk of obese patients.
A thorough preoperative evaluation of comorbidities, an anaesthesia induction and
intraoperative ventilation tailored to the pathophysiological sequelae of obesity
and a sound knowledge of pharmokocinetics are necessary to ensure optimal care for
obese patients.
Schlüsselwörter:
Allgemeinanästhesie - Schlaf–Apnoe–Syndrom - Adipositas - perioperatives Management
Keywords:
Obesity - obstructive sleep apnea - general anaesthesia - perioperative management
Kernaussagen
-
Die Zahl übergewichtiger und adipöser Patienten nimmt zu. Damit steigt auch der Anteil
dieser Patientenpopulation bei operativen Eingriffen.
-
Adipositas ist mit Hypertonus, Fettstoffwechselstörungen, Diabetes mellitus und kardiovaskulären
Erkrankungen assoziiert. Die meisten Patienten haben außerdem ein Schlaf–Apnoe–Syndrom.
-
Für die Versorgung adipöser Patienten müssen räumlich–apparative Voraussetzungen geschaffen
werden, und es muss ein erfahrenes Team bereitstehen.
-
Anästhesierelevante Besonderheiten sind Atemwegsprobleme, erschwertes intraoperatives
Monitoring und perioperative respiratorische Komplikationen.
-
Regionalanästhesiologische Verfahren sollten, wenn möglich, bevorzugt werden.
-
Bei Durchführung einer Allgemeinanästhesie bieten moderne Inhalationsanästhetika und
Remifentanil Vorteile.
-
Die Präoxygenierung ist besonders wichtig. Hierfür ist die umgekehrte Trendelenburg–Lagerung
geeignet. Eine CPAP–Atmung vor Einleitung ist empfehlenswert.
-
Die postoperative Schmerztherapie sollte regionalanästhesiologische Verfahren und
NSAID beinhalten.
Literatur
- 1 Krankheitskosten je Einwohner in €.
gbe-bund.de
2006
- 2
Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM..
Prevalence of overweight and obesity in the United States, 1999–2004.
Jama.
2006;
295
1549-1555
- 3
Bergmann K, Mensink G..
Körpermaße und Übergewicht.
Gesundheitswesen.
1999;
61
115-120
- 4
Prugger C, Keil U..
Development of obesity in Germany––prevalence, determinants and perspectives.
Dtsch Med Wochenschr.
2007;
132
892-897
- 5
Lamerz A, Kuepper–Nybelen J, Wehle C, Bruning N, Trost–Brinkhues G, Brenner H, Hebebrand J,
Herpertz–Dahlmann B..
Social class, parental education, and obesity prevalence in a study of six–ear–old
children in Germany.
Int J Obes (Lond).
2005;
29
373-380
- 6
Kuczmarski RJ, Flegal KM, Campbell SM, Johnson CL..
Increasing prevalence of overweight among US adults. The National Health and Nutrition
Examination Surveys, 1960 to 1991.
Jama.
1994;
272
205-211
- 7
Adams KF, Schatzkin A, Harris TB, Kipnis V, Mouw T, Ballard–Barbash R, Hollenbeck A,
Leitzmann MF..
Overweight, obesity, and mortality in a large prospective cohort of persons 50 to
71 years old.
N Engl J Med.
2006;
355
763-778
- 8
Bogers RP, Bemelmans WJ, Hoogenveen RT, Boshuizen HC, Woodward M, Knekt P, van RM Dam,
Hu FB, Visscher TL, Menotti A, Thorpe RJ, Jr., Jamrozik K, Calling S, Strand BH, Shipley MJ..
Association of overweight with increased risk of coronary heart disease partly independent
of blood pressure and cholesterol levels: a meta–analysis of 21 cohort studies including
more than 300 000 persons.
Arch Intern Med.
2007;
167
1720-1728
- 9
Wilson PW, D'Agostino RB, Sullivan L, Parise H, Kannel WB..
Overweight and obesity as determinants of cardiovascular risk: the Framingham experience.
Arch Intern Med.
2002;
162
1867-1872
- 10
Stelfox HT, Ahmed SB, Ribeiro RA, Gettings EM, Pomerantsev E, Schmidt U..
Hemodynamic monitoring in obese patients: the impact of body mass index on cardiac
output and stroke volume.
Crit Care Med.
2006;
34
1243-1246
- 11
Caterson ID, Hubbard V, Bray GA, Grunstein R, Hansen BC, Hong Y, Labarthe D, Seidell JC,
Smith Jr. SC.
Prevention Conference VII: Obesity, a worldwide epidemic related to heart disease
and stroke: Group III: worldwide comorbidities of obesity.
Circulation.
2004;
110
476-483
- 12
Colditz GA, Willett WC, Stampfer MJ, Manson JE, Hennekens CH, Arky RA, Speizer FE..
Weight as a risk factor for clinical diabetes in women.
Am J Epidemiol.
1990;
132
501-513
- 13 Valdivielso P, Sanchez–Chaparro MA, Calvo–Bonacho E, Cabrera–Sierra M, Sainz–Gutierrez JC,
Fernandez–Labandera C, Fernandez–Meseguer A, Quevedo–Aguado L, Moraga MR, Galvez–Moraleda A,
Gonzalez–Quintela A, Roman–Garcia J.. Association of moderate and severe hypertriglyceridemia
with obesity, diabetes mellitus and vascular disease in the Spanish working population:
Results of the ICARIA study. Atherosclerosis 2009 (Epub ahead of print)
- 14
Knuiman JT, West CE, Burema J..
Serum total and high density lipoprotein cholesterol concentrations and body mass
index in adult men from 13 countries.
Am J Epidemiol.
1982;
116
631-642
- 15
Rexrode KM, Hennekens CH, Willett WC, Colditz GA, Stampfer MJ, Rich–Edwards JW, Speizer FE,
Manson JE..
A prospective study of body mass index, weight change, and risk of stroke in women.
Jama.
1997;
277
1539-1545
- 16
Pischon T, Nothlings U, Boeing H..
Obesity and cancer.
Proc Nutr Soc.
2008;
67
128-145
- 17
Calle EE, Rodriguez C, Walker–Thurmond K, Thun MJ..
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of
U.S. adults.
N Engl J Med.
2003;
348
1625-1638
- 18 Zoremba M, Dette F, Hunecke T, Braunecker S, Wulf H.. The influence of perioperative
oxygen concentration on postoperative lung function in moderately obese adults. Eur
J Anaesthesiol 2009
- 19
Isono S..
Obstructive sleep apnea of obese adults: pathophysiology and perioperative airway
management.
Anesthesiology.
2009;
110
908-921
- 20
Marin JM, Carrizo SJ, Vicente E, Agusti AG..
Long–term cardiovascular outcomes in men with obstructive sleep apnoea–hypopnoea with
or without treatment with continuous positive airway pressure: an observational study.
Lancet.
2005;
365
1046-1053
- 21
Yaggi HK, Concato J, Kernan WN, Lichtman JH, Brass LM, Mohsenin V..
Obstructive sleep apnea as a risk factor for stroke and death.
N Engl J Med.
2005;
353
2034-2041
- 22
Watanabe T, Isono S, Tanaka A, Tanzawa H, Nishino T..
Contribution of body habitus and craniofacial characteristics to segmental closing
pressures of the passive pharynx in patients with sleep–disordered breathing.
Am J Respir Crit Care Med.
2002;
165
260-265
- 23
van der Weide L, van Sornsen de Koste JR, Lagerwaard FJ, Vincent A, van Triest B,
Slotman BJ, Senan S..
Analysis of carina position as surrogate marker for delivering phase–gated radiotherapy.
Int J Radiat Oncol Biol Phys.
2008;
71
1111-1117
- 24
Thut DC, Schwartz AR, Roach D, Wise RA, Permutt S, Smith PL..
Tracheal and neck position influence upper airway airflow dynamics by altering airway
length.
J Appl Physiol.
1993;
75
2084-2090
- 25
Van de Graaff WB..
Thoracic traction on the trachea: mechanisms and magnitude.
J Appl Physiol.
1991;
70
1328-1336
- 26
Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S..
The occurrence of sleep–disordered breathing among middle–aged adults.
N Engl J Med.
1993;
328
1230-1235
- 27
Calle EE, Teras LR, Thun MJ..
Obesity and mortality.
N Engl J Med.
2005;
353
2197-2199
- 28
Calle EE, Thun MJ, Petrelli JM, Rodriguez C, Heath Jr. CW.
Body–mass index and mortality in a prospective cohort of U.S. adults.
N Engl J Med.
1999;
341
1097-1105
- 29
Flegal KM, Graubard BI, Williamson DF, Gail MH..
Excess deaths associated with underweight, overweight, and obesity.
Jama.
2005;
293
1861-1867
- 30
Casati A, Putzu M..
Anesthesia in the obese patient: pharmacokinetic considerations.
J Clin Anesth.
2005;
17
134-145
- 31
Pai MP, Paloucek FP..
The origin of the "ideal" body weight equations.
Ann Pharmacother.
2000;
34
1066-1069
- 32
Lemmens HJ, Brodsky JB, Bernstein DP..
Estimating ideal body weight––a new formula.
Obes Surg.
2005;
15
1082-1083
- 33
Albertin A, Poli D, La L Colla, Gonfalini M, Turi S, Pasculli N, La Colla G, Bergonzi PC,
Dedola E, Fermo I..
Predictive performance of 'Servin's formula' during BIS–guided propofol–remifentanil
target–controlled infusion in morbidly obese patients.
Br J Anaesth.
2007;
98
66-75
- 34
Wada DR, Bjorkman S, Ebling WF, Harashima H, Harapat SR, Stanski DR..
Computer simulation of the effects of alterations in blood flows and body composition
on thiopental pharmacokinetics in humans.
Anesthesiology.
1997;
87
884-899
- 35
Slepchenko G, Simon N, Goubaux B, Levron JC, Le JP Moing, Raucoules–Aime M..
Performance of target–controlled sufentanil infusion in obese patients.
Anesthesiology.
2003;
98
65-73
- 36
Egan TD, Huizinga B, Gupta SK, Jaarsma RL, Sperry RJ, Yee JB, Muir KT..
Remifentanil pharmacokinetics in obese versus lean patients.
Anesthesiology.
1998;
89
562-573
- 37
Leykin Y, Pellis T, Lucca M, Lomangino G, Marzano B, Gullo A..
The pharmacodynamic effects of rocuronium when dosed according to real body weight
or ideal body weight in morbidly obese patients.
Anesth Analg.
2004;
99
- 38
Lemmens HJ, Brodsky JB..
The dose of succinylcholine in morbid obesity.
Anesth Analg.
2006;
102
438-442
- 39
Arain SR, Barth CD, Shankar H, Ebert TJ..
Choice of volatile anesthetic for the morbidly obese patient: sevoflurane or desflurane.
J Clin Anesth.
2005;
17
413-419
- 40
Brodsky JB, Lemmens HJ, Saidman LJ..
Obesity, surgery, and inhalation anesthetics –– is there a "drug of choice"?.
Obes Surg.
2006;
16
734
- 41
Casati A, Marchetti C, Spreafico E, Mamo D..
Effects of obesity on wash–in and wash–out kinetics of sevoflurane.
Eur J Anaesthesiol.
2004;
21
243-245
- 42
La G Colla, La L Colla, Turi S, Poli D, Albertin A, Pasculli N, Bergonzi PC, Gonfalini M,
Ruggieri F..
Effect of morbid obesity on kinetic of desflurane: wash–in wash–out curves and recovery
times.
Minerva Anestesiol.
2007;
73
275-279
- 43
Lemmens HJ, Saidman LJ, Eger 2nd EI, Laster MJ..
Obesity modestly affects inhaled anesthetic kinetics in humans.
Anesth Analg.
2008;
107
1864-1870
- 44
Juvin P, Vadam C, Malek L, Dupont H, Marmuse JP, Desmonts JM..
Postoperative recovery after desflurane, propofol, or isoflurane anesthesia among
morbidly obese patients: a prospective, randomized study.
Anesth Analg.
2000;
91
714-719
- 45 Hauner H, Buchholz G, Hamann A, Husemann B, Koletzko B, Liebermeister H, Wabitsch M,
Westenhöfer J, Wirth A, Wolfram G.. Evidenzbasierte Leitlinie: Prävention und Therapie
der Adipositas. Deutsche Adipositas Gesellschaft 2007
- 46
Fleisher LA, Beckman JA, Brown KA, Calkins H, Chaikof E, Fleischmann KE, Freeman WK,
Froehlich JB, Kasper EK, Kersten JR, Riegel B, Robb JF, Smith Jr. SC, Jacobs AK, Adams CD,
Anderson JL, Antman EM, Buller CE, Creager MA, Ettinger SM, Faxon DP, Fuster V, Halperin JL,
Hiratzka LF, Hunt SA, Lytle BW, Md RN, Ornato JP, Page RL, Riegel B, Tarkington LG,
Yancy CW..
ACC/AHA 2007 Guidelines on Perioperative Cardiovascular Evaluation and Care for Noncardiac
Surgery: Executive Summary: A Report of the American College of Cardiology/American
Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the
2002 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery):
Developed in Collaboration With the American Society of Echocardiography, American
Society of Nuclear Cardiology, Heart Rhythm Society, Society of Cardiovascular Anesthesiologists,
Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine
and Biology, and Society for Vascular Surgery.
Circulation.
2007;
116
1971-1996
- 47
Pawlik MT, Hansen E, Waldhauser D, Selig C, Kuehnel TS..
Clonidine premedication in patients with sleep apnea syndrome: a randomized, double–blind,
placebo–controlled study.
Anesth Analg.
2005;
101
1374-1380
- 48
Brodsky JB, Lemmens HJ..
Regional anesthesia and obesity.
Obes Surg.
2007;
17
1146-1149
- 49
Nielsen KC, Guller U, Steele SM, Klein SM, Greengrass RA, Pietrobon R..
Influence of obesity on surgical regional anesthesia in the ambulatory setting: an
analysis of 9,038 blocks.
Anesthesiology.
2005;
102
181-187
- 50
Hodgkinson R, Husain FJ..
Obesity, gravity, and spread of epidural anesthesia.
Anesth Analg.
1981;
60
421-424
- 51
Madan AK, Ternovits CA, Speck KE, Tichansky DS..
Inpatient pain medication requirements after laparoscopic gastric bypass.
Obes Surg.
2005;
15
778-781
- 52
Baraka AS, Taha SK, Aouad MT, El–Khatib MF, Kawkabani NI..
Preoxygenation: comparison of maximal breathing and tidal volume breathing techniques.
Anesthesiology.
1999;
91
612-616
- 53
Dixon BJ, Dixon JB, Carden JR, Burn AJ, Schachter LM, Playfair JM, Laurie CP, O'Brien PE..
Preoxygenation is more effective in the 25 degrees head–up position than in the supine
position in severely obese patients: a randomized controlled study.
Anesthesiology.
2005;
102
- 54
Altermatt FR, Munoz HR, Delfino AE, Cortinez LI..
Pre–oxygenation in the obese patient: effects of position on tolerance to apnoea.
Br J Anaesth.
2005;
95
706-709
- 55
Valenza F, Vagginelli F, Tiby A, Francesconi S, Ronzoni G, Guglielmi M, Zappa M, Lattuada E,
Gattinoni L..
Effects of the beach chair position, positive end–expiratory pressure, and pneumoperitoneum
on respiratory function in morbidly obese patients during anesthesia and paralysis.
Anesthesiology.
2007;
107
725-732
- 56
Gander S, Frascarolo P, Suter M, Spahn DR, Magnusson L..
Positive end–xpiratory pressure during induction of general anesthesia increases duration
of nonhypoxic apnea in morbidly obese patients.
Anesth Analg.
2005;
100
580-584
- 57
Freid EB..
The rapid sequence induction revisited: obesity and sleep apnea syndrome.
Anesthesiol Clin North America.
2005;
23
- 58
Vaughan RW, Bauer S, Wise L..
Volume and pH of gastric juice in obese patients.
Anesthesiology.
1975;
43
686-689
- 59
Wisen O, Hellstrom PM..
Gastrointestinal motility in obesity.
J Intern Med.
1995;
237
411-418
- 60
Zacchi P, Mearin F, Humbert P, Formiguera X, Malagelada JR..
Effect of obesity on gastroesophageal resistance to flow in man.
Dig Dis Sci.
1991;
36
1473-1480
- 61
Nuckton TJ, Glidden DV, Browner WS, Claman DM..
Physical examination: Mallampati score as an independent predictor of obstructive
sleep apnea.
Sleep.
2006;
29
903-908
- 62
Kheterpal S, Han R, Tremper KK, Shanks A, Tait AR, O'Reilly M, Ludwig TA..
Incidence and predictors of difficult and impossible mask ventilation.
Anesthesiology.
2006;
105
885-891
- 63
Cooper RM..
The LMA, laparoscopic surgery and the obese patient – can vs should: Le ML, la chirurgie
laparoscopique et le patient obese – pouvoir vs devoir.
Can J Anaesth.
2003;
50
5-10
- 64
Zoremba M, Aust H, Eberhart L, Braunecker S, Wulf H..
Comparison between intubation and the laryngeal mask airway in moderately obese adults.
Acta Anaesthesiol Scand.
2009;
53
436-442
- 65
Cadi P, Guenoun T, Journois D, Chevallier JM, Diehl JL, Safran D..
Pressure–controlled ventilation improves oxygenation during laparoscopic obesity surgery
compared with volume–controlled ventilation.
Br J Anaesth.
2008;
100
709-716
- 66
Perilli V, Sollazzi L, Modesti C, Annetta MG, Sacco T, Bocci MG, Tacchino RM, Proietti R..
Comparison of positive end–expiratory pressure with reverse Trendelenburg position
in morbidly obese patients undergoing bariatric surgery: effects on hemodynamics and
pulmonary gas exchange.
Obes Surg.
2003;
13
605-609
- 67
Kallet RH, Branson RD..
Respiratory controversies in the critical care setting. Do the NIH ARDS Clinical Trials
Network PEEP/FIO2 tables provide the best evidence–based guide to balancing PEEP and FIO2 settings in adults?.
Respir Care.
2007;
52
75-77
- 68
von Ungern–Sternberg BS, Regli A, Reber A, Schneider MC..
Effect of obesity and thoracic epidural analgesia on perioperative spirometry.
Br J Anaesth.
2005;
94
121-127
- 69
Taylor S, Kirton OC, Staff I, Kozol RA..
Postoperative day one: a high risk period for respiratory events.
Am J Surg.
2005;
190
752-756
- 70
Rennotte MT, Baele P, Aubert G, Rodenstein DO..
Nasal continuous positive airway pressure in the perioperative management of patients
with obstructive sleep apnea submitted to surgery.
Chest.
1995;
107
367-374
- 71 Preventing and managing the global epidemic. Report of a WHO consultation on obesity. Genf
1998
- 72
Katzmarzyk PT, Craig CL, Bouchard C..
Original article underweight, overweight and obesity: relationships with mortality
in the 13–year follow–up of the Canada Fitness Survey.
J Clin Epidemiol.
2001;
54
916-920
- 73
Bender R, Jockel KH, Trautner C, Spraul M, Berger M..
Effect of age on excess mortality in obesity.
Jama.
1999;
281
1498-1504
- 74 WHO. .Adipositas und Übergewicht. Fact Sheet No. 311: www.who.int/mediacentre/factsheets/fs311/en/print.html
PD Dr. med. Berthold Bein
Dr. med. Jan Höcker
Dr. med. Axel Fudickar
Prof. Dr. med. Jens Scholz
Email: bein@anaesthesie.uni-kiel.de
Email: hoecker@anaesthesie.uni-kiel.de
Email: fudickar@anaesthesie.uni-kiel.de