Gypenoside LXXIV Ameliorates Scopolamine-Induced Learning Deficit in Mice

Abstract

Gypenoside LXXIV (G-74), a major constituent of Gynostemma pentaphyllum Makino (GP; family Cucurbitaceae), was isolated and its memory-enhancing effects were investigated in scopolamine-treated mice in passive-avoidance and Morris water maze tests. G-74 potently reversed memory impairment caused by scopolamine. G-74 also significantly shortened the scopolamine-prolonged escape latencies in the Morris water maze test (p < 0.05) and increased the scopolamine-shortened swimming time within the platform quadrant (p < 0.05). Based on these findings, G-74 might improve learning deficits.

Key words

Gynostemma pentaphyllum - Cucurbitaceae - gypenoside LXXIV - learning - memory - scopolamine

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