Endoscopy 2009; 41: E281-E282
DOI: 10.1055/s-0029-1215007
Unusual cases and technical notes

© Georg Thieme Verlag KG Stuttgart · New York

Lansoprazole-associated collagenous colitis: unique presentation, similar to ischemic colitis

H.  Yusuke1 , T.  Jun1 , M.  Naotaka1 , T.  Yuichi1 , E.  Yutaka1 , I.  Kazuaki1
  • 1Department of Internal Medicine, Fujigaoka Hospital, Showa University, Yokohama, Japan
Further Information

Y. Hashimoto, MD 

Department of Internal Medicine
Fujigaoka Hospital
Showa University

1-30 Aoba-ku Fujigaoka
Yokohama
Japan 227-8501

Fax: +81-045-9713824

Email: yu-hashimoto@showa-university-fujigaoka.gr.jp

Publication History

Publication Date:
28 October 2009 (online)

Table of Contents

Recently, there have been reports of lansoprazole-associated collagenous colitis manifesting some characteristic clinical findings: chronic diarrhea, typical endoscopic findings, pathological evidence of collagen bands, and rapid clinical improvement after discontinuation of lansoprazole. We have also often encountered patients taking lansoprazole presenting with chronic diarrhea and typical endoscopic findings. Although one published article has stated that linear ulcers and ulcer scars should be considered specific for lansoprazole-associated collagenous colitis, another has not mentioned endoscopic findings at all [1] [2]. However, severe ulcers rarely cause colonic perforation [3]. Here we present a patient with lansoprazole-associated collagenous colitis who presented a unique clinical picture, similar to that of ischemic colitis.

A 78-year-old Japanese woman attended our emergency room because of abrupt onset of lower abdominal pain and heavy blood in her stool. She had been taking lansoprazole since 2 months and had chronic diarrhea. Initially, ischemic colitis was suspected and an abdominopelvic computed tomography (CT) scan revealed a thick-walled and edematous sigmoid colon ([Fig. 1]). Colonoscopy was performed to confirm the diagnosis and revealed a 20-cm long hemorrhagic, linear ulcer and a 15-cm linear ulcer scar in the sigmoid colon ([Fig. 2]). Histopathological examination of biopsy samples taken from the sigmoid colon showed subepithelial collagen bands ([Fig. 3]). Finally, a diagnosis of collagenous colitis was made. The cause was though to be lansoprazole and this was discontinued. Six days later, the patient was discharged with complete resolution of the diarrhea and abdominal pain. A repeat colonoscopy 2 months after admission showed healing linear lesions and scars ([Fig. 4]). No collagen bands were identified on a biopsy specimen.

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Fig. 1 Abdominopelvic computed tomography (CT) scan demonstrating the thick-walled sigmoid colon.

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Fig. 2 Colonoscopy showing an actively hemorrhagic linear ulcer and a linear ulcer scar.

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Fig. 3 Biopsy specimen showing markedly thickened subepithelial collagen bands.

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Fig. 4 Follow-up colonoscopy revealed the complete healing of the linear ulcer.

The present case highlights the fact that lansoprazole-associated collagenous colitis may present with atypical clinical, imaging, and endoscopic findings.

Endoscopy_UCTN_Code_CCL_1AD_2AJ

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References

Y. Hashimoto, MD 

Department of Internal Medicine
Fujigaoka Hospital
Showa University

1-30 Aoba-ku Fujigaoka
Yokohama
Japan 227-8501

Fax: +81-045-9713824

Email: yu-hashimoto@showa-university-fujigaoka.gr.jp

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References

Y. Hashimoto, MD 

Department of Internal Medicine
Fujigaoka Hospital
Showa University

1-30 Aoba-ku Fujigaoka
Yokohama
Japan 227-8501

Fax: +81-045-9713824

Email: yu-hashimoto@showa-university-fujigaoka.gr.jp

Zoom Image

Fig. 1 Abdominopelvic computed tomography (CT) scan demonstrating the thick-walled sigmoid colon.

Zoom Image

Fig. 2 Colonoscopy showing an actively hemorrhagic linear ulcer and a linear ulcer scar.

Zoom Image

Fig. 3 Biopsy specimen showing markedly thickened subepithelial collagen bands.

Zoom Image

Fig. 4 Follow-up colonoscopy revealed the complete healing of the linear ulcer.