Animal Models for the Study of Osteomyelitis

Mitul Patel; Yuri Rojavin; Amir A Jamali; Samantha J Wasielewski; Christopher J Salgado

doi:10.1055/s-0029-1214167

Seminars in Plastic Surgery, Table of Contents

Semin Plast Surg 2009; 23(2): 148-154
DOI: 10.1055/s-0029-1214167

Animal Models for the Study of Osteomyelitis

Mitul Patel¹ , Yuri Rojavin¹ , Amir A. Jamali² , Samantha J. Wasielewski¹ , Christopher J. Salgado³

¹Department of Surgery, Cooper University Hospital, Robert Wood Johnson Medical School, Camden, New Jersey
²Department of Orthopedic Surgery, UC Davis Medical Center, Sacramento, California
³Department of Plastic Surgery, University Hospitals Cleveland, Case Western Reserve University, Cleveland, Ohio

Abstract

ABSTRACT

Osteomyelitis is an acute or chronic inflammatory process of the bone and its related structures secondary to an infection with pyogenic organisms. Because of the variety in disease presentations and pathophysiology of osteomyelitis, it is very difficult to evaluate in clinical studies. Therefore, animal models have been created for in vivo experimentation. A PubMed and OVID search was performed on March 31, 2008, using keywords osteomyelitis, animal model (rabbit, rat, mouse, avian, dog, sheep, and goat), and experimental osteomyelitis. The objective of this review was to provide a literature review of the animal models created to study osteomyelitis. The models were chosen based on historical relevance and clinical applicability. Numerous animal models exist to study both acute and chronic osteomyelitis. Many models have been created that allow investigators to study various aspects in the treatment and diagnosis of osteomyelitis. Based on the needs of investigators, an animal model must be carefully selected for ideal research, as no single model encompasses all aspects of osteomyelitis.

KEYWORDS

Osteomyelitis - animal models - rabbit - goat - mouse - canine

Full Text

References

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Christopher J SalgadoM.D.

Department of Plastic Surgery, University Hospitals Cleveland, Case Western Reserve University

11100 Euclid Avenue, Cleveland, OH 44106

Email: salgado_plastics@hotmail.com