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Planta Med 2010; 76(5): 412-417
DOI: 10.1055/s-0029-1186237
Pharmacology
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Ameliorative Effect of the Cinnamon Oil from Cinnamomum zeylanicum upon Early Stage Diabetic Nephropathy

Awanish Mishra1 , Rajbir Bhatti1 , Amarjit Singh2 , Mohan Paul Singh Ishar1
  • 1Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India
  • 2Department of Pathology, Government Medical College, Amritsar, Punjab, India
Further Information

Publication History

received July 17, 2009 revised Sept. 20, 2009

accepted Sept. 28, 2009

Publication Date:
29 October 2009 (online)

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Abstract

The current study was designed to evaluate the ameliorative effect of the cinnamon oil upon early stage diabetic nephropathy owing to its antioxidant and antidiabetic effect. Cinnamon oil was extracted by hydro-distillation of the dried inner bark of Cinnamomum zeylanicum Blume. Further characterization of the extracted oil was carried out using IR, 1H‐NMR, and 13C‐NMR techniques. Early stage of diabetic nephropathy was induced by administration of alloxan (150 mg/kg, i. p.). Cinnamon oil was administered at varying doses (5, 10, 20 mg/kg; i. p.) while the level of fasting blood glucose, total cholesterol, high density lipoprotein, urea, thiobarbituric acid reactive substances, reduced glutathione, and catalase were determined. These parameters in cinnamon oil treated groups were compared with those of standard (glipizide; 10 mg/kg) and vehicle treated groups in order to investigate if cinnamon oil confers a significant protection against diabetic nephropathy. Histological studies of the kidney proved the protective effect of cinnamon oil by reducing the glomerular expansion, eradicating hyaline casts, and decreasing the tubular dilatations. Our results indicate that the volatile oil from cinnamon contains more than 98 % cinnamaldehyde and that it confers dose-dependent, significant protection against alloxan-induced renal damage, the maximum decrease in fasting blood glucose having been achieved at the dose of 20 mg/kg.

Key words

Cinnamomum zeylanicum Blume - Lauraceae - cinnamaldehyde - alloxan - diabetic nephropathy

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Awanish Mishra

Pharmacology Division, Department of Pharmaceutical Sciences and Drug Research
Punjabi University

Patiala

Punjab, PIN 147002

India

Phone: + 91 98 88 13 66 42

Email: awanish1985@gmail.com

    www.thieme-connect.de/ejournals/toc/plantamedica