Planta Med 2010; 76(3): 276-277
DOI: 10.1055/s-0029-1186081
Pharmacology
Letters
© Georg Thieme Verlag KG Stuttgart · New York

α-Glucosidase Inhibitory, Aromatase Inhibitory, and Antiplasmodial Activities of a Biflavonoid GB1 from Garcinia kola Stem Bark

Bassey S. Antia1 , 2 , Acharavadee Pansanit3 , Okon D. Ekpa2 , Udofot J. Ekpe2 , Chulabhorn Mahidol1 , 3 , 4 , Prasat Kittakoop1 , 3
  • 1Chulabhorn Research Institute, Vibhavadi-Rangsit Highway, Bangkok, Thailand
  • 2Department of Pure and Applied Chemistry, University of Calabar, Calabar, Nigeria
  • 3Chulabhorn Graduate Institute and the Center for Environmental Health, Toxicology and Management of Chemicals (ETM), Chemical Biology Program, Vibhavadi-Rangsit Highway, Bangkok, Thailand
  • 4Chulabhorn Research Centre, Institute of Science and Technology for Research and Development, Mahidol University, Bangkok, Thailand
Further Information

Publication History

received June 8, 2009 revised July 22, 2009

accepted July 31, 2009

Publication Date:
09 September 2009 (online)

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Abstract

The biflavonoid, 3′′,4′,4′′′,5,5′′,7,7′′-heptahydroxy-3,8-biflavanone, known as GB1 (1), was isolated as a major constituent from Garcinia kola stem bark. GB1 (1) exhibited α-glucosidase and aromatase inhibitory activities, as well as antiplasmodial activity, but was not toxic against cell lines tested. GB1 (1) may be a potential dietary supplement or phytomedicine for the prevention of breast cancer and type 2 diabetes mellitus.

References

Dr. Prasat Kittakoop

Chulabhorn Research Institute

Vibhavadi-Rangsit Highway

10210 Bangkok

Thailand

Phone: + 66 8 69 75 57 77

Fax: + 66 25 74 06 22 ext. 15 13

Email: prasatkittakoop@yahoo.com