Resveratrol und seine Bedeutung für die Anti-Aging-Medizin

Zusammenfassung

Resveratrol ist ein potentes Antioxidans, das auch antiinflammatorische und chemopräventive Wirkungen aufweist. Darüber hinaus besitzt es eine Eigenschaft, die vor allem für die Anti-Aging-Medizin von größter Bedeutung ist: Resveratrol täuscht dem Körper eine Kalorienrestriktion vor, von der man weiß, dass sie bis heute die einzige experimentell belegte Methode zur Lebensverlängerung ist.

Resveratrol - Rotwein - Antioxidans - CR‐Mimetika

Literatur

• 1 Aggarwal B B, Bhardwaj A, Aggarwal R S, Seeram N P, Shishodia S, Takada Y. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies.  Anticancer Res. 2004;  24 2783-2840
• 2 Anderson R M, Bittermann K J, Wood J G, Medvedik O, Sinclair D A. Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae.  Nature. 2003;  423 181-185
• 3 Araki T, Sasaki Y, Milbrandt J. Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration.  Science. 2004;  305 1010-1013
• 4 Criqui M H, Ringel B L. Does diet or alcohol explain the French paradox?.  Lancet. 1994;  344 1719-1723
• 5 Crowell J A, Korytko P J, Morrisey R L, Levine B S. Resveratrol-associated renal toxicity.  Toxicol Sci. 2004;  82 614-619
• 6 Dorrie J C, Gerauer H, Wachter Y, Zunino S J. Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukaemia cells.  Cancer Res. 2001;  61 4731-4739
• 7 Frankel E N, Waterhouse A L, Kinsella J E. Inhibition of human LDL oxidation by resveratrol.  Lancet. 1993;  341 1103-1104
• 8 Fulda S, Debatin K M. Sensitization for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by the chemopreventive agent resveratrol.  Cancer Res. 2004;  64 337-346
• 9 Gronbaek M, Deis A, Sorensen T IA, Becker U, Schnohr P, Jensen G. Mortality associated with moderate intakes of wine, beer, or spirits.  BMJ. 1995;  310 1165-1169
• 10 Howitz K T, Bitterman K J, Cohen H Y, Lamming D W, Lavu S, Wood J G, Zipkin R E, Chung P, Kisielewski A, Zhang L L, Scherer B, Sinclair D A. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.  Nature. 2003;  425 191-196
• 11 Hung L M, Chen J K, Huang S S, Lee R S, Su M J. Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes.  Cardiovasc Res. 2000;  47 549-555
• 12 Ignatowicz E, Baer-Dubowska W. Resveratrol, a natural chemopreventive agent against degenerative diseases.  Pol J Pharmacol. 2001;  53 557-569
• 13 Jang M S, Cai E N, Udeani G O, Slowing K V, Thomas C F. et al . Cancer chemopreventive activity of resveratrol, a natural product derived from grapes.  Science. 2002;  275 218-220
• 14 Baur J A, Pearson K J, Price N L. et al . Resveratrol improves health and survival of mice on a high-calorie diet.  Nature. 2006;  444 337-342
• 15 Kevin S. Gould, nature's swiss army knife: the diverse protective roles of Anthocyanins in leaves.  J Biomed Biotechnol. 2004;  5 314-320
• 16 Klatsky A L, Armstrong M A, Friedman G D. Red wine, white wine, liquor, beer and risk for coronary artery disease hospitalization.  Am J Cardiol. 1997;  80 416-420
• 17 Kundu J K, Surh Y-J. Molecular basis of chemoprevention by resveratrol: NF-kappaB and AP‐1 as potential targets.  Mutat Res. 2004;  555 65-80
• 18 Langley E, Pearson M, Faretta M, Bauer U M, Frye R A, Minucci S, Pelicci P G, Kouzarides T. Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence.  EMBO J. 2002;  21 2383-2396
• 19 Leonard S, Xia C, Jiang B H, Stinefelt B, Klandorf H, Harris G K, Shi X. Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses.  Biochem Biophys Res Commun. 2003;  309 1017-1026
• 20 Lin S J, Defossez P A, Guarente L. Requirement of NAD and SIR 2 for lifespan extension by calorie restriction in Saccharomyces cerevisiae.  Science. 2000;  289 2126-2128
• 21 Mahyar-Roemer M, Kohler H, Roemer K. Role of Bax in resveratrol-induced apoptosis of colorectal carcinoma cells.  BMC Cancer. 2002;  2 27-36
• 22 Martinez J, Moreno J J. Effect of resveratrol, a natural polyphenolic compound, on reactive oxygen species and prostaglandin production.  Biochem Pharmacol. 2000;  59 865-870
• 23 Marx J. Cancer research. Inflammation and cancer: the link grows stronger.  Science. 2004;  306 966-968
• 24 McCay C M, Cromwell M F, Maynard L A. The effect of retarded growth upon the length of life span upon the ultimate body size.  J Nutr. 1935;  10 63-79
• 25 McGeer E G, McGeer P L. Inflammatory processes in Alzheimer's disease.  Prog Neuropsychopharmacol Biol Psychiatry. 2003;  27 741-749
• 26 Mertens-Talcott S U, Percival S S. Ellagic acid and quercetin interact synergistically with resveratrol in the induction of apoptosis and cause translent cell cycle arrest in human leukemia cells.  Cancer Lett. 2005;  218 141-152
• 27 Olas B, Zbikowska H M, Wachowicz B, Krajewski A, Magnuszewska A. Inhibitory effect of resveratrol on free radical generation in blood platelets.  Acta Biochem Pol. 1999;  46 961-966
• 28 Pervaiz S. Reveratrol. From grapevines to mammalian biology.  FASEB J. 2003;  17 1975-1985
• 29 Philip M, Rowley D A, Schreiber H. Inflammation as a tumor promoter in cancer induction.  Semin Cancer Biol. 2004;  14 433-439
• 30 Renaud S, de Lorgeril M. Wine, alcohol, platelets and the French paradox for coronary heart disease.  Lancet. 1992;  339 1523-1526
• 31 Savaskan E, Olivieri G, Meier F, Seifritz E, Wirz-Justice A, Muller-Spahn F. Red wine ingredient resveratrol protects from beta-amyloid neurotoxicity.  Gerontology. 2003;  49 380-383
• 32 Steinberg D, Parthasarathy S, Carew T E, Khoo J C, Witzthum J L. Beyond cholesterol. Modifications of low-density lipoprotein that increase its atherogenicity.  N Engl J Med. 1989;  320 915-924
• 33 Subbaramaiah K, Michaluart P, Chung W J, Tanabe T, Telang N, Dannenberg A J. Resveratrol inhibits cyclooxygenase-2 transcription in human mammary epithelial cells.  Ann NY Acad Sci. 1999;  889 214-223
• 34 Tsai S H, Lin-Shiau S Y, Lin J K. Suppression of nitric oxide synthase and the down-regulation of the activation of NFkappaB in macrophages by resveratrol.  Br J Pharmacol. 1999;  126 673-680
• 35 Virgili M, Contestabile A. Partial neuroprotection of in vivo excitotoxic brain damage by chronic administration of the red wine antioxidant agent, trans-resveratrol in rats.  Neurosci Lett. 2000;  281 123-126
• 36 Walle T, Hsieh F, DeLegge M H. et al . High absorption but very low bioavailability of oral resveratrol in humans.  Drug Metab Dispos. 2004;  32 1377-1382
• 37 Willerson J T, Ridker P M. Inflammation as a cardiovascular risk factor.  Circulation. 2004;  109 II2-II10
• 38 Wood J G, Rogina B, Lavu S, Howitz S L, Helfland S L, Tatar M, Sinclair D. Sirtuin activators mimic calorie restriction and delay ageing in metazoans.  Nature. 2004;  430 686-689