New Benzamide Derivatives and NO Production Inhibitory Compounds from Limonia acidissima

Abstract

Three new benzamide derivatives, N-{[p-(3,7-dimethyl-6R,7-dihydroxy-4R-octadecanoyloxy-2-octenyloxy)phenyl]ethyl} benzamide (1), N-{[p-(3,7-dimethyl-6R,7-dihydroxy-4R-9′′′(E)-octadecenoyloxy-2-octenyloxy)phenyl]ethyl} benzamide (2), and N-{[p-(3,7-dimethyl-6R,7-epoxy-4R-9′′′(E)-octadecenoyloxy-2-octenyloxy)phenyl]ethyl} benzamide (3), together with 10 known compounds (4–13), were isolated from the bark of Limonia acidissima. The structures of these new compounds were determined through spectral analyses, including extensive 2D NMR data. Among the isolates, 13α,14β,17α-lanosta-7,9,24-triene-3β,16α-diol (8), 4-methoxy-1-methyl-2(1H)-quinolinone (10), and 13α,14β,17α-lanosta-7,24-diene-3β,11β,16α-triol (13) potently inhibited nitric oxide (NO) production in microglia cells.

Key words

Limonia acidissima - Rutaceae - benzamide derivative - NO production inhibitory activity

References

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