Acetylcholinesterase Activity of Alkaloids from the Leaves of Waltheria brachypetala

Abstract

Chemical investigation of the leaves of Waltheria brachypetala Turks (Sterculiaceae) resulted in the isolation of quinolinone alkaloids, waltherione-A, waltherione-B (N-methylwaltherione-A), 8-methoxyflindersine, and the cyclic peptide alkaloid waltherine. The inhibition of activity of acetylcholinesterase (AChE) by the alkaloids was evaluated. Waltherione-A, waltherione-B and waltherine showed significant activity.

Abbreviations

AChE:acetylcholinesterase

DTNB:5,5′-dithio-bis(2-nitrobenzoic acid)

Key words

Waltheria brachypetala - Sterculiaceae - quinolinone alkaloids - acetylcholinesterase inhibitors

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