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Horm Metab Res 1971; 3(3): 161-166
DOI: 10.1055/s-0028-1094168
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© Georg Thieme Verlag KG Stuttgart · New York

Studies on the Interaction between Growth Hormone and Dihydroergotamine in Adipose Cells[*] - I. The Lipolytic Effect of Dihydroergotamine

N.  Hotta [**] , O. V. Sirek , Anna  Sirek
  • Department of Physiology, and Division of Teaching Laboratories, University of Toronto, Toronto, Canada
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Publication History

Publication Date:
07 January 2009 (online)

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Studies on the Interaction between Growth Hormone and Dihydroergotamine in Adipose Cells - II. Augmentation of the Lipolytic ResponseHorm Metab Res 1971; 3(05): 321-325
DOI: 10.1055/s-0028-1094135

Abstract

The lipolytic and antilipolytic effects of dihydroergotamine (DHE) were studied on isolated rat epididymal adipose tissue cells in terms of glycerol and free fatty acid release. The lipolytic effect of DHE was augmented by the addition of theophylline and was suppressed by propranolol, Kö 592, phentolamine, and insulin. DHE blocked the lipolytic effect of adrenaline, but had no effect on lipolysis caused by ACTH, TSH and glucagon. The results suggest that DHE has multiple sites of action at points preceding the formation of cyclic AMP. They appear to be closely related to catecholamine receptor sites and unrelated to receptor sites of other lipolytic hormones.

Key words

Lipolysis - Isolated Fat Cell - Dihydroergotamine - Adrenaline - ACTH - TSH - Glucagon - Adrenergic Blockers

1 Supported by the Atkinson Charitable Foundation of Toronto, and Hoechst Pharmaceuticals of Canada.

1 Supported by the Atkinson Charitable Foundation of Toronto, and Hoechst Pharmaceuticals of Canada.

2 Holder of a Fellowship from the Medical Research Council of Canada. Permanent address: Third Department of Medicine, University of Nagoya, Nagoya, Japan.

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