Semin Liver Dis 2008; 28(4): 337
DOI: 10.1055/s-0028-1091977
FOREWORD

© Thieme Medical Publishers

Fatty Liver Disease

Arun J. Sanyal1
  • 1Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, Virginia
Further Information

Publication History

Publication Date:
27 October 2008 (online)

An epidemic of nonalcoholic fatty liver disease (NAFLD) is upon the Western world. The clinical and histologic spectrum of this condition has been characterized to include nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH). Over the last 5 years, a remarkable amount of information has been generated with respect to all aspects of this condition. Disturbing new data indicate that NAFLD is widely prevalent even among children and that certain ethnic groups are more susceptible to this condition. Although the underlying metabolic disturbances that lead to hepatic steatosis and pathways that cause cell injury, inflammation, and fibrosis have been unraveled to a great extent, these data have raised additional questions. Also, new information on the relative contribution of hepatocyte injury and death on one hand and regeneration on the other provide novel targets for therapy. From a clinical point of view, it is becoming increasingly clear that NAFLD is not simply a medical curiosity, but contributes broadly to both adverse hepatic and cardiovascular outcomes. There have also been substantial advances in the ability to make the diagnosis of NAFLD as well as both grade and stage the disease. These changing paradigms related to the diagnosis and evaluation of NAFLD have been accompanied by advancements in the development of therapies for NAFLD, although weight loss and treatment of insulin resistance remain central to the therapeutic process. The state of the art of these topics is reviewed by some of the leading authorities in this issue. It is hoped that both those involved in clinical practice and research related to NAFLD will find this information of value.

Arun J SanyalM.B.B.S. M.D. 

Professor of Internal Medicine, Pharmacology, and Pathology

MCV Box 980341, Richmond, VA 23298-0341

Email: ajsanyal@hsc.vcu.edu

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